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Protein

Hepcidin

Gene

HAMP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:HAMP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 5330Sequence analysisPRO_0000013383Add
BLAST
Peptidei58 – 8225HepcidinPRO_0000013384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 80By similarity
Disulfide bondi67 ↔ 70By similarity
Disulfide bondi68 ↔ 76By similarity
Disulfide bondi71 ↔ 79By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8MJ80.

Expressioni

Gene expression databases

BgeeiENSSSCG00000002886.
ExpressionAtlasiQ8MJ80. differential.
GenevisibleiQ8MJ80. SS.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ8MJ80.
OMAiCGICCKT.
TreeFamiTF330932.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MJ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSVQIRAA CLLLLLLVSL TAGSVLPSQT RQLTDLRTQD TAGATAGLTP
60 70 80
VAQRLRRDTH FPICIFCCGC CRKAICGMCC KT
Length:82
Mass (Da):8,771
Last modified:October 1, 2002 - v1
Checksum:i78F23A1C9D01E4EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516143 mRNA. Translation: AAM77745.1.
RefSeqiNP_999282.1. NM_214117.1.
UniGeneiSsc.376.

Genome annotation databases

EnsembliENSSSCT00000003189; ENSSSCP00000003108; ENSSSCG00000002886.
GeneIDi397207.
KEGGissc:397207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516143 mRNA. Translation: AAM77745.1.
RefSeqiNP_999282.1. NM_214117.1.
UniGeneiSsc.376.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ8MJ80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000003189; ENSSSCP00000003108; ENSSSCG00000002886.
GeneIDi397207.
KEGGissc:397207.

Organism-specific databases

CTDi57817.

Phylogenomic databases

GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ8MJ80.
OMAiCGICCKT.
TreeFamiTF330932.

Gene expression databases

BgeeiENSSSCG00000002886.
ExpressionAtlasiQ8MJ80. differential.
GenevisibleiQ8MJ80. SS.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEPC_PIG
AccessioniPrimary (citable) accession number: Q8MJ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.