ID   DHPR_PIG                Reviewed;         243 AA.
AC   Q8MJ30;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Dihydropteridine reductase;
DE            EC=1.5.1.34;
DE   AltName: Full=HDHPR;
DE   AltName: Full=Quinoid dihydropteridine reductase;
GN   Name=QDPR; Synonyms=DHPR;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22351655; PubMed=12464030;
RX   DOI=10.1046/j.1365-2052.2002.00938_6.x;
RA   Kim J.G., Nonneman D., Vallet J.L., Rohrer G.A., Christenson R.K.;
RT   "Linkage mapping of a single nucleotide polymorphism (SNP) in the
RT   porcine QDPR gene to chromosome 8.";
RL   Anim. Genet. 33:474-474(2002).
CC   -!- FUNCTION: The product of this enzyme, tetrahydrobiopterin (BH-4),
CC       is an essential cofactor for phenylalanine, tyrosine, and
CC       tryptophan hydroxylases (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a
CC       6,7-dihydropteridine + NAD(P)H.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF526879; AAM91996.1; -; mRNA.
DR   RefSeq; NP_999508.1; -.
DR   UniGene; Ssc.17250; -.
DR   HSSP; P11348; 1DHR.
DR   SMR; Q8MJ30; 8-243.
DR   GeneID; 397619; -.
DR   KEGG; ssc:397619; -.
DR   HOVERGEN; Q8MJ30; -.
DR   BRENDA; 1.5.1.34; 249.
DR   GO; GO:0004155; F:6,7-dihydropteridine reductase activity; ISS:UniProtKB.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; NADP; Oxidoreductase; Tetrahydrobiopterin biosynthesis.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    243       Dihydropteridine reductase.
FT                                /FTId=PRO_0000054638.
FT   NP_BIND      13     37       NADP (By similarity).
FT   ACT_SITE    149    149       Proton acceptor (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   243 AA;  25758 MW;  53A6634FE7D015CC CRC64;
     MAAAAAGEAR RVLVYGGRGA LGSRCVQAFR ARNWWVASID VVENEEASAN VVVKMTDSFT
     EQADQVTAEV GKLLGTEKVD AILCVAGGWA GGNAKSKSLF KNCDLMWKQS MWTSTISSHL
     ATKHLKEGGL LTLAGAKAAL DGTPGMIGYG MAKGAVHQLC QSLAGKDSGM PSGAAAIAVL
     PVTLDTPLNR KSMPHADFSS WTPLEFLVET FHDWIIEKNR PSSGSLIQVV TTQGKTELTP
     AYF
//