Reviewed, UniProtKB/Swiss-Prot Q8MJ30 (DHPR_PIG)

Names and origin

Protein names

Recommended name:
    Dihydropteridine reductase
    EC=1.5.1.34
Alternative name(s):
    HDHPR
    Quinoid dihydropteridine reductase

Gene names

Name:	QDPR
Synonyms:	DHPR

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases By similarity.
Catalytic activity	A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	6,7-dihydropteridine reductase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 243	242	Dihydropteridine reductase		PRO_0000054638
Regions
	Nucleotide binding	13 – 37	25	NADP By similarity
Sites
	Active site	149	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MJ30-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 53A6634FE7D015CC	FASTA	243	25,758
	10 20 30 40 50 60 MAAAAAGEAR RVLVYGGRGA LGSRCVQAFR ARNWWVASID VVENEEASAN VVVKMTDSFT 70 80 90 100 110 120 EQADQVTAEV GKLLGTEKVD AILCVAGGWA GGNAKSKSLF KNCDLMWKQS MWTSTISSHL 130 140 150 160 170 180 ATKHLKEGGL LTLAGAKAAL DGTPGMIGYG MAKGAVHQLC QSLAGKDSGM PSGAAAIAVL 190 200 210 220 230 240 PVTLDTPLNR KSMPHADFSS WTPLEFLVET FHDWIIEKNR PSSGSLIQVV TTQGKTELTP AYF

References

[1]	"Linkage mapping of a single nucleotide polymorphism (SNP) in the porcine QDPR gene to chromosome 8." Kim J.G., Nonneman D., Vallet J.L., Rohrer G.A., Christenson R.K. Anim. Genet. 33:474-474(2002) [PubMed: 12464030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF526879 mRNA. Translation: AAM91996.1.
RefSeq	NP_999508.1.
UniGene	Ssc.17250
3D structure databases
HSSP	HSSP built from PDB template 1DHR based on UniProtKB P11348.
SMR	Q8MJ30. Positions 8-243.
ModBase	Search...
Genome annotation databases
GeneID	397619.
KEGG	ssc:397619.
Phylogenomic databases
HOVERGEN	Q8MJ30.
Family and domain databases
InterPro	IPR002198. DHase_sc/Rdtase_SDR. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

DHPR_PIG

Accession

Primary (citable) accession number: Q8MJ30

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	October 1, 2002
Last modified:	July 22, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)