Reviewed, UniProtKB/Swiss-Prot Q8MJ26 (GYS1_MACMU)

Names and origin

Protein names

Recommended name:
    Glycogen [starch] synthase, muscle
    EC=2.4.1.11

Gene names

Name:	GYS1
Synonyms:	GYS

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	737 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan By similarity.
Catalytic activity	UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).
Enzyme regulation	Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.
Pathway	Glycan biosynthesis; glycogen biosynthesis.
Sequence similarities	Belongs to the glycosyltransferase 3 family.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
PTM	Phosphoprotein
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological process	glycogen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycogen (starch) synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 737	737	Glycogen [starch] synthase, muscle		PRO_0000194764
Sites
	Binding site	39	1	UDP-glucose By similarity
Amino acid modifications
	Modified residue	8	1	Phosphoserine; by PKA By similarity
	Modified residue	11	1	Phosphoserine By similarity
	Modified residue	641	1	Phosphoserine By similarity
	Modified residue	645	1	Phosphoserine By similarity
	Modified residue	649	1	Phosphoserine By similarity
	Modified residue	653	1	Phosphoserine By similarity
	Modified residue	657	1	Phosphoserine By similarity
	Modified residue	698	1	Phosphoserine By similarity
	Modified residue	710	1	Phosphoserine By similarity
	Modified residue	727	1	Phosphoserine By similarity
	Modified residue	731	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MJ26-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B8B0B3114C58F56C	FASTA	737	83,787
	10 20 30 40 50 60 MPLNRTLSMS SLPGLEDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK AKVTGDEWGD 70 80 90 100 110 120 NYYLVGPYTE QGVRTQVELL EAPTPALKKT LDSMNSKGCK VYFGRWLIEG GPLVVLLDVG 130 140 150 160 170 180 ASAWALERWK GELWDTCNIG VPWYDREAND AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH 190 200 210 220 230 240 EWLAGIGLCL CRARRLPVAT IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH 250 260 270 280 290 300 RYCMERAAAH CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 310 320 330 340 350 360 KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN YLLRVNGSEQ 370 380 390 400 410 420 TVVALFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF GRKLYESLLV GSLPDMNKML 430 440 450 460 470 480 DKEDFTMMKR AIFATQRQSF PPVCTHNMLD DSSDPILTTI RRIGLFNSSA DRVKVIFHPE 490 500 510 520 530 540 FLSSTSPLLP VDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE 550 560 570 580 590 600 HIADPSAYGI YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 610 620 630 640 650 660 LGRYYMSARH MALSKAFPEH FTYEPSEADA AQGYRYPRPA SVPPSPSLSR HSSPHQSEDE 670 680 690 700 710 720 EDPRNGPLEE DSERYDEDEE AAKDRRNIRA PEWPRRASCT SSTSGSKRNS VDTATSSSLS 730 TPSEPLSPTS SLGEERN

References

[1]	"Monkey skeletal muscle glycogen synthase sequence." Ortmeyer H.K., Marciani K.R., Hansen B.C. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF529178 mRNA. Translation: AAM93267.1.
RefSeq	NP_001028058.1.
UniGene	Mmu.3861
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT3. Glycosyltransferase Family 3.
Genome annotation databases
Ensembl	ENSMMUG00000003911. Macaca mulatta. [Contig view]
GeneID	574233.
KEGG	mcc:574233.
Phylogenomic databases
HOVERGEN	Q8MJ26.
Enzyme and pathway databases
BRENDA	2.4.1.11. 1774.
Family and domain databases
InterPro	IPR008631. Glycogen_synth. [Graphical view]
PANTHER	PTHR10176. Glycogen_synth. 1 hit.
Pfam	PF05693. Glycogen_syn. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYS1_MACMU

Accession

Primary (citable) accession number: Q8MJ26

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)