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Protein

Lysyl oxidase homolog 4

Gene

LOXL4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the formation of a collagenous extracellular matrix.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi612CopperSequence analysis1
Metal bindingi614CopperSequence analysis1
Metal bindingi616CopperSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Gene namesi
Name:LOXL4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004544126 – 757Lysyl oxidase homolog 4Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 123PROSITE-ProRule annotation
Disulfide bondi72 ↔ 133PROSITE-ProRule annotation
Disulfide bondi103 ↔ 113PROSITE-ProRule annotation
Disulfide bondi192 ↔ 277PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi205 ↔ 287PROSITE-ProRule annotation
Disulfide bondi252 ↔ 262PROSITE-ProRule annotation
Disulfide bondi337 ↔ 401PROSITE-ProRule annotation
Disulfide bondi350 ↔ 411PROSITE-ProRule annotation
Disulfide bondi381 ↔ 391PROSITE-ProRule annotation
Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
Disulfide bondi464 ↔ 529PROSITE-ProRule annotation
Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi559 ↔ 565PROSITE-ProRule annotation
Disulfide bondi611 ↔ 659PROSITE-ProRule annotation
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Cross-linki639 ↔ 675Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi643 ↔ 649PROSITE-ProRule annotation
Disulfide bondi671 ↔ 681PROSITE-ProRule annotation
Modified residuei6752',4',5'-topaquinoneBy similarity1
Disulfide bondi718 ↔ 732PROSITE-ProRule annotation

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

PaxDbiQ8MJ24.
PRIDEiQ8MJ24.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020895.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027838.

Structurei

3D structure databases

ProteinModelPortaliQ8MJ24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 134SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini160 – 288SRCR 2PROSITE-ProRule annotationAdd BLAST129
Domaini312 – 412SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini422 – 530SRCR 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni534 – 737Lysyl-oxidase likeBy similarityAdd BLAST204

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated
Contains 4 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ8MJ24.
KOiK00280.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 2 hits.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MJ24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLPAALPL LPLLLLLGQA PPSRPQSLGT MKLRLVGPGS GPEEGRLEVL
60 70 80 90 100
HQGQWGTVCD DDFALQEATV ACRQLGFEGA LTWAHSAKYG SGEGPIWLDN
110 120 130 140 150
VHCVGTESSL DQCGSNGWGV SDCTHSEDVG VVCNPQRHRG SVSERVSNAL
160 170 180 190 200
GPQDRRLEEV RLKPILASAK RQSPVTEGAV EVKYEGHWRQ VCDQGWTRNN
210 220 230 240 250
SRVVCGMLGF PSEAPVDSHH YRKVWDSKMK DPNSRLKSLT KKNSFWIHRV
260 270 280 290 300
NCLGTEPHMA NCQVQVAPAQ GKLRPACPGG MHAVVSCVAG PRFRPPKAKP
310 320 330 340 350
GRKESRAEEM KVRLRSGAQV GEGRVEVLMN RQWGTVCDHG WNLISASVVC
360 370 380 390 400
RQLGFGSARE ALFGAQLGQA LGPIHLSEVR CRGYERTLSD CPSLEGSQNG
410 420 430 440 450
CQHDNDAAVR CNIPNMGFQD QVRLAGGRSP EEGVVEVQVE VNGVQRWGAV
460 470 480 490 500
CSDHWGLSEA MVACRQLGLG FASHAIKDTW YWQGTPGARE VVMSGVHCSG
510 520 530 540 550
TELALQQCQR HGPVHCSHGT GRFSAGVSCT DSAPDLVMNA QLVQETAYLE
560 570 580 590 600
DRPLSLLYCA HEENCLSQSA DRMDWPYGHR RLLRFSSQIH NLGRADFRPK
610 620 630 640 650
MGRHGWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP
660 670 680 690 700
TGMQRRYACA NFGEQGVTVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV
710 720 730 740 750
NPKFEVAESD FSNNMMRCRC KYDGQRVWLH NCHTGDSYRA NTELSQEQEQ

RLRNNLI
Length:757
Mass (Da):84,050
Last modified:October 1, 2002 - v1
Checksum:i0A17A02C2D793984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529202 mRNA. Translation: AAM94335.1.
RefSeqiNP_776809.1. NM_174384.2.
UniGeneiBt.12297.

Genome annotation databases

GeneIDi281904.
KEGGibta:281904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529202 mRNA. Translation: AAM94335.1.
RefSeqiNP_776809.1. NM_174384.2.
UniGeneiBt.12297.

3D structure databases

ProteinModelPortaliQ8MJ24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027838.

Proteomic databases

PaxDbiQ8MJ24.
PRIDEiQ8MJ24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281904.
KEGGibta:281904.

Organism-specific databases

CTDi84171.

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ8MJ24.
KOiK00280.

Gene expression databases

BgeeiENSBTAG00000020895.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 2 hits.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOXL4_BOVIN
AccessioniPrimary (citable) accession number: Q8MJ24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.