Q8MJ14 (GPX1_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase 1
Short name=GPx-1
Short name=GSHPx-1
EC=1.11.1.9

Alternative name(s):
Cellular glutathione peroxidase

Gene names

Name:

GPX1

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects the hemoglobin in erythrocytes from oxidative breakdown By similarity.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer. Interacts with MIEN1 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Molecular function	Oxidoreductase Peroxidase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Glutathione peroxidase 1		PRO_0000066614
Sites
	Active site	52	1	By similarity
Amino acid modifications
	Non-standard residue	52	1	Selenocysteine
	Modified residue	151	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MJ14 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 4431BECD35A797A0	FASTA	206	22,591
	10 20 30 40 50 60 MCAAQRSAAA LAAVAPRSVY AFSARPLAGG EPISLGSLRG KVLLIENVAS LUGTTVRDYT 70 80 90 100 110 120 QMNELQRRLG PRGLVVLGFP CNQFGHQENA KNGEILNCLK YVRPGGGFEP NFMLFEKCEV 130 140 150 160 170 180 NGANAHPLFA FLREALPTPS DDATALMTDP KFITWSPVCR NDIAWNFEKF LVGPDGVPLR 190 200 RYSRRFLTID IEPDIEALLS QEPSSA

References

[1]	"Sus scrofa selenium-containing enzyme cytosolic glutathione peroxidase 1 (cGPX1) from the day 13 embryo." Hostetler C.E., Robison M.R., Kincaid R.L., Ott T.L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF532927 mRNA. Translation: AAM94630.1.
RefSeq	NP_999366.1. NM_214201.1.
UniGene	Ssc.6352.
3D structure databases
ProteinModelPortal	Q8MJ14.
ModBase	Search...
Protein family/group databases
PeroxiBase	3722. SscGPx01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397403.
KEGG	ssc:397403.
Organism-specific databases
CTD	2876.
Phylogenomic databases
HOVERGEN	HBG004333.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX1_PIG

Accession

Primary (citable) accession number: Q8MJ14

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	February 26, 2008
Last modified:	December 14, 2011
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program