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Protein

Prostaglandin E2 receptor EP4 subtype

Gene

PTGER4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP4 subtype
Short name:
PGE receptor EP4 subtype
Short name:
PGE2 receptor EP4 subtype
Alternative name(s):
Prostanoid EP4 receptor
Gene namesi
Name:PTGER4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 43Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini44 – 55CytoplasmicSequence analysisAdd BLAST12
Transmembranei56 – 79Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini80 – 96ExtracellularSequence analysisAdd BLAST17
Transmembranei97 – 115Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini116 – 135CytoplasmicSequence analysisAdd BLAST20
Transmembranei136 – 160Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini161 – 184ExtracellularSequence analysisAdd BLAST24
Transmembranei185 – 211Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini212 – 273CytoplasmicSequence analysisAdd BLAST62
Transmembranei274 – 301Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini302 – 318ExtracellularSequence analysisAdd BLAST17
Transmembranei319 – 338Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini339 – 492CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892981 – 492Prostaglandin E2 receptor EP4 subtypeAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation
Modified residuei380PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8MJ08.

Interactioni

Subunit structurei

Interacts with FEM1A.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019930.

Structurei

3D structure databases

ProteinModelPortaliQ8MJ08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000251595.
HOVERGENiHBG053556.
InParanoidiQ8MJ08.
KOiK04261.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001758. Prost_EP4_rcpt.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF6. PTHR11866:SF6. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00586. PRSTNOIDEP4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MJ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPGTNASS SQASNPLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK
60 70 80 90 100
ETTFYTLVCG LAVTDLLGTL LVSPVTIATY LKGQWPGGHA LCEYSTFILL
110 120 130 140 150
FFGLSGLSII CAMSIERYLA INHAYFYSHY VDKRLAGLTL FAVYASNVLF
160 170 180 190 200
CALPSMGLGS SRLQYPATWC FIDWTTNVTA HAAFSYMYAG FSSFLILATV
210 220 230 240 250
LCNVLVCGAL LRMHRQFMRR TSLGTEQQHH AAAAAVALAP TACRAPPAAS
260 270 280 290 300
SPALPRLSDF RRRRSFRRIA GAEIQMVILL IATSLVVLIC SIPLVVRVFV
310 320 330 340 350
NQLYRPQLEP VIGKNPDLQA IRIASVSPIL DPWIYILLRK TVLSKAIEKI
360 370 380 390 400
KCLFCRIGGS RRERSGPHCS DSRRTSSAVS GHSRSFLSRE LKEISSTSQT
410 420 430 440 450
LLYTPELSEN GLGGGRNLLP GVPGVGLTQI DSTSLRTLRI SETSDSSQGQ
460 470 480 490
DSESFLLVDE VGGSCRAGPA PKGSSLQVTF PSETLNLSEK CI
Length:492
Mass (Da):53,298
Last modified:October 1, 2002 - v1
Checksum:iE9119F5E72D00873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539403 mRNA. Translation: AAN01235.1.
RefSeqiNP_777014.1. NM_174589.2.
UniGeneiBt.111479.

Genome annotation databases

GeneIDi282331.
KEGGibta:282331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539403 mRNA. Translation: AAN01235.1.
RefSeqiNP_777014.1. NM_174589.2.
UniGeneiBt.111479.

3D structure databases

ProteinModelPortaliQ8MJ08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019930.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8MJ08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282331.
KEGGibta:282331.

Organism-specific databases

CTDi5734.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000251595.
HOVERGENiHBG053556.
InParanoidiQ8MJ08.
KOiK04261.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001758. Prost_EP4_rcpt.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF6. PTHR11866:SF6. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00586. PRSTNOIDEP4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R4_BOVIN
AccessioniPrimary (citable) accession number: Q8MJ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.