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Protein

Natural cytotoxicity triggering receptor 3

Gene

NCR3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 3
Alternative name(s):
Natural killer cell p30-related protein
Short name:
NK-p30
Short name:
NKp30
CD_antigen: CD337
Gene namesi
Name:NCR3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 133115ExtracellularSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 20147CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 201183Natural cytotoxicity triggering receptor 3PRO_0000015034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 108PROSITE-ProRule annotation
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011616.

Structurei

3D structure databases

ProteinModelPortaliQ8MJ02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 126108Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRYX. Eukaryota.
ENOG410ZQ2V. LUCA.
HOGENOMiHOG000040000.
HOVERGENiHBG052590.
InParanoidiQ8MJ02.
KOiK06743.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 5 (identifier: Q8MJ02-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWMLLLILI MVYPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI
60 70 80 90 100
GSVTWFRDEV APGKEVRNGT PEFRGRLAPL SSSRFLRDHQ AELHIWDVRG
110 120 130 140 150
HDAGIYVCRV EVLGLGVGTG NGTRLVVEKE YPQLGAGTVL LLRAGFYAVS
160 170 180 190 200
FLSVAMGSTL YYQGKCLTWK GPRRQLPAVV PGPLPPPCGS SAHLLPPVPG

G
Length:201
Mass (Da):21,684
Last modified:May 10, 2005 - v2
Checksum:iAE3A325C8585BA68
GO
Isoform 1 (identifier: Q8MJ02-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-180: LTWKGPRRQLPAVV → HCHMGTHCHSSDGP
     181-201: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):19,640
Checksum:i5C2DF53487B2A3B6
GO
Isoform 2 (identifier: Q8MJ02-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-90: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):18,805
Checksum:iDF98DF1BE4B2A13F
GO
Isoform 3 (identifier: Q8MJ02-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-115: VLGL → NILS
     116-201: Missing.

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):12,871
Checksum:i1D34CC0E8986DE9F
GO
Isoform 4 (identifier: Q8MJ02-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-201: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):19,389
Checksum:i54BB9D13D225B8E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561M → V.2 Publications

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 9025Missing in isoform 2. CuratedVSP_010414Add
BLAST
Alternative sequencei112 – 1154VLGL → NILS in isoform 3. CuratedVSP_010415
Alternative sequencei116 – 20186Missing in isoform 3. CuratedVSP_010416Add
BLAST
Alternative sequencei167 – 18014LTWKG…LPAVV → HCHMGTHCHSSDGP in isoform 1. CuratedVSP_013641Add
BLAST
Alternative sequencei177 – 20125Missing in isoform 4. CuratedVSP_010417Add
BLAST
Alternative sequencei181 – 20121Missing in isoform 1. CuratedVSP_013642Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035214 mRNA. Translation: AAK63116.1.
AY035215 mRNA. Translation: AAK63117.1.
AY035216 mRNA. Translation: AAK63118.1.
AY035217 mRNA. Translation: AAK63119.1.
AJ554301 mRNA. Translation: CAD86942.1.
AB128049 Genomic DNA. Translation: BAD69721.1.
RefSeqiNP_001036105.1. NM_001042640.1. [Q8MJ02-1]
XP_014991417.1. XM_015135931.1.
UniGeneiMmu.3643.

Genome annotation databases

GeneIDi715574.
KEGGimcc:715574.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035214 mRNA. Translation: AAK63116.1.
AY035215 mRNA. Translation: AAK63117.1.
AY035216 mRNA. Translation: AAK63118.1.
AY035217 mRNA. Translation: AAK63119.1.
AJ554301 mRNA. Translation: CAD86942.1.
AB128049 Genomic DNA. Translation: BAD69721.1.
RefSeqiNP_001036105.1. NM_001042640.1. [Q8MJ02-1]
XP_014991417.1. XM_015135931.1.
UniGeneiMmu.3643.

3D structure databases

ProteinModelPortaliQ8MJ02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi715574.
KEGGimcc:715574.

Organism-specific databases

CTDi259197.

Phylogenomic databases

eggNOGiENOG410IRYX. Eukaryota.
ENOG410ZQ2V. LUCA.
HOGENOMiHOG000040000.
HOVERGENiHBG052590.
InParanoidiQ8MJ02.
KOiK06743.

Miscellaneous databases

NextBioi19978152.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rhesus monkey NKp46 and NKp30 and identification of NKp46SD and NKp30S."
    LaBonte M.L., Miller J., Letvin N.L.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3 AND 4), VARIANT VAL-156.
  2. "NCR express by macaca NK cells."
    Rizzi M., Biassoni R.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 4), VARIANT VAL-156.
    Tissue: Lymphoid tissue.
  3. "Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex."
    Kulski J.K., Anzai T., Shiina T., Inoko H.
    Mol. Biol. Evol. 21:2079-2091(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 5).

Entry informationi

Entry nameiNCTR3_MACMU
AccessioniPrimary (citable) accession number: Q8MJ02
Secondary accession number(s): Q5TM24
, Q8MJ00, Q8MJ01, Q95JB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 10, 2005
Last modified: March 16, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.