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Q8MIU0

- TYRO_BOVIN

UniProt

Q8MIU0 - TYRO_BOVIN

Protein

Tyrosinase

Gene

TYR

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone By similarity.By similarity

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi180 – 1801Copper ABy similarity
    Metal bindingi202 – 2021Copper ABy similarity
    Metal bindingi211 – 2111Copper ABy similarity
    Metal bindingi363 – 3631Copper BBy similarity
    Metal bindingi367 – 3671Copper BBy similarity
    Metal bindingi390 – 3901Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC
    3. protein heterodimerization activity Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    SABIO-RKQ8MIU0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:TYR
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome Source: UniProtKB
    3. melanosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in TYR are the cause of a form of albinism in Braunvieh calf.

    Keywords - Diseasei

    Albinism

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 530513TyrosinasePRO_0000035876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8MIU0.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 473455Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini495 – 53036CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG08919.
    HOGENOMiHOG000118376.
    HOVERGENiHBG003553.
    InParanoidiQ8MIU0.
    KOiK00505.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MIU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLAALYCLL WSFRTSAGHF PRACASSKSL TEKECCPPWA GDGSPCGRLS    50
    GRGSCQDVIL STAPLGPQFP FTGVDDRESW PSIFYNRTCQ CFSNFMGFNC 100
    GSCKFGFRGP RCTERRLLVR RNIFDLSVPE KNKFLAYLTL AKHTTSPDYV 150
    IPTGTYGQMN HGTTPLFNDV SVYDLFVWMH YYVSRDTLLG DSEVWRDIDF 200
    AHEAPGFLPW HRLFLLLWEQ EIQKLTGDEN FTIPYWDWRD AENCDVCTDE 250
    YMGGRNPANP NLLSPASFFS SWQIVCSRLE EYNSRQALCN GTSEGPLLRN 300
    PGNHDKARTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFADP 350
    VTGIADASQS SMHNALHIYM NGTMSQVPGS ANDPIFLLHH AFVDSIFEQW 400
    LRKYHPLQDV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDXGYDYS 450
    YLQDSEPDIF QDYIKPYLEQ AQRIWPWLIG AAVVGSVLTA VLGGLTSLLC 500
    RRKRNQLPEE KQPLLMEKED YHNLMYQSHL 530
    Length:530
    Mass (Da):60,304
    Last modified:March 1, 2003 - v2
    Checksum:i1C0CEF3D8CB1356C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti172 – 1721V → A in AAL38168. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046527 mRNA. Translation: AAL02331.2.
    AF445639 mRNA. Translation: AAL38168.1.
    RefSeqiNP_851344.1. NM_181001.3.
    UniGeneiBt.9028.

    Genome annotation databases

    GeneIDi280951.
    KEGGibta:280951.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Snowy stardom - Issue 49 of August 2004

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046527 mRNA. Translation: AAL02331.2 .
    AF445639 mRNA. Translation: AAL38168.1 .
    RefSeqi NP_851344.1. NM_181001.3.
    UniGenei Bt.9028.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8MIU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 280951.
    KEGGi bta:280951.

    Organism-specific databases

    CTDi 7299.

    Phylogenomic databases

    eggNOGi NOG08919.
    HOGENOMi HOG000118376.
    HOVERGENi HBG003553.
    InParanoidi Q8MIU0.
    KOi K00505.

    Enzyme and pathway databases

    SABIO-RK Q8MIU0.

    Miscellaneous databases

    NextBioi 20805063.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A form of albinism in cattle is caused by a tyrosinase frameshift mutation."
      Schmutz S.M., Berryere T.G., Ciobanu D.C., Mileham A.J., Schmidtz B.H., Fredholm M.
      Mamm. Genome 15:62-67(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INVOLVEMENT IN ALBINISM.
      Strain: White Galloway.
    2. "Transcriptional regulation of bovine TYR gene."
      Guibert S., Julien R., Oulmouden A.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiTYRO_BOVIN
    AccessioniPrimary (citable) accession number: Q8MIU0
    Secondary accession number(s): Q8WN56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3