ID   CCL11_MACMU             Reviewed;          97 AA.
AC   Q8MIT7;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 108.
DE   RecName: Full=Eotaxin;
DE   AltName: Full=C-C motif chemokine 11;
DE   AltName: Full=Small-inducible cytokine A11;
DE   Flags: Precursor;
GN   Name=CCL11; Synonyms=SCYA11;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhang L., Soares M.P., Guan Y., Sirotina-Meisher A., Matheravidathu S.,
RA   Iliff S.A., Mudgett J.S., Springer M.S., Daugherty B.L.;
RT   "Molecular cloning of eotaxin/CCL11 and CCR3 from rhesus monkey. Functional
RT   expression and characterization of rhesus monkey CCR3 in murine L1-2 cells;
RT   generation of antibodies against rhesus CCR3.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In response to the presence of allergens, this protein
CC       directly promotes the accumulation of eosinophils (a prominent feature
CC       of allergic inflammatory reactions), but not lymphocytes, macrophages
CC       or neutrophils (By similarity). Binds to CCR3 (By similarity).
CC       {ECO:0000250|UniProtKB:P48298, ECO:0000250|UniProtKB:P51671}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97545}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY049019; AAL13086.1; -; mRNA.
DR   AlphaFoldDB; Q8MIT7; -.
DR   SMR; Q8MIT7; -.
DR   STRING; 9544.ENSMMUP00000070332; -.
DR   GlyCosmos; Q8MIT7; 1 site, No reported glycans.
DR   PaxDb; 9544-ENSMMUP00000012806; -.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   HOGENOM; CLU_141716_1_0_1; -.
DR   InParanoid; Q8MIT7; -.
DR   TreeFam; TF334888; -.
DR   Proteomes; UP000006718; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF146; EOTAXIN; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..97
FT                   /note="Eotaxin"
FT                   /id="PRO_0000005196"
FT   CARBOHYD        94
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
FT   DISULFID        32..57
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
FT   DISULFID        33..73
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
SQ   SEQUENCE   97 AA;  10855 MW;  9BCA0FD6D95B02DD CRC64;
     MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR RIISGKCPQK
     AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP
//