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Protein

Eotaxin

Gene

CCL11

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000519624 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94O-linked (GalNAc...) threonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009783
ExpressionAtlasiQ8MIT7 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012806

Structurei

3D structure databases

ProteinModelPortaliQ8MIT7
SMRiQ8MIT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ8MIT7
OMAiGSKCPQK
OrthoDBiEOG091G14KV
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MIT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR
60 70 80 90
RIISGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP
Length:97
Mass (Da):10,855
Last modified:October 1, 2002 - v1
Checksum:i9BCA0FD6D95B02DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049019 mRNA Translation: AAL13086.1
UniGeneiMmu.3651

Similar proteinsi

Entry informationi

Entry nameiCCL11_MACMU
AccessioniPrimary (citable) accession number: Q8MIT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health