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Protein

Eotaxin

Gene

CCL11

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity).By similarity

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. mammary duct terminal end bud growth Source: Ensembl
  7. positive regulation of actin filament polymerization Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of Rac GTPase activity Source: Ensembl
  12. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ8MIT7. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ8MIT7.
SMRiQ8MIT7. Positions 24-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ8MIT7.
OMAiGSKCPQK.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MIT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR
60 70 80 90
RIISGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP
Length:97
Mass (Da):10,855
Last modified:September 30, 2002 - v1
Checksum:i9BCA0FD6D95B02DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049019 mRNA. Translation: AAL13086.1.
UniGeneiMmu.3651.

Genome annotation databases

EnsembliENSMMUT00000013666; ENSMMUP00000012806; ENSMMUG00000009783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049019 mRNA. Translation: AAL13086.1.
UniGeneiMmu.3651.

3D structure databases

ProteinModelPortaliQ8MIT7.
SMRiQ8MIT7. Positions 24-97.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000013666; ENSMMUP00000012806; ENSMMUG00000009783.

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ8MIT7.
OMAiGSKCPQK.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Gene expression databases

ExpressionAtlasiQ8MIT7. baseline.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of eotaxin/CCL11 and CCR3 from rhesus monkey. Functional expression and characterization of rhesus monkey CCR3 in murine L1-2 cells; generation of antibodies against rhesus CCR3."
    Zhang L., Soares M.P., Guan Y., Sirotina-Meisher A., Matheravidathu S., Iliff S.A., Mudgett J.S., Springer M.S., Daugherty B.L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL11_MACMU
AccessioniPrimary (citable) accession number: Q8MIT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: September 30, 2002
Last modified: January 6, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.