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Q8MIT7 (CCL11_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene names
Name:CCL11
Synonyms:SCYA11
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9774Eotaxin
PRO_0000005196

Amino acid modifications

Glycosylation941O-linked (GalNAc...) By similarity
Disulfide bond32 ↔ 57 By similarity
Disulfide bond33 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8MIT7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9BCA0FD6D95B02DD

FASTA9710,855
        10         20         30         40         50         60 
MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR RIISGKCPQK 

        70         80         90 
AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP 

« Hide

References

[1]"Molecular cloning of eotaxin/CCL11 and CCR3 from rhesus monkey. Functional expression and characterization of rhesus monkey CCR3 in murine L1-2 cells; generation of antibodies against rhesus CCR3."
Zhang L., Soares M.P., Guan Y., Sirotina-Meisher A., Matheravidathu S., Iliff S.A., Mudgett J.S., Springer M.S., Daugherty B.L.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY049019 mRNA. Translation: AAL13086.1.
UniGeneMmu.3651.

3D structure databases

ProteinModelPortalQ8MIT7.
SMRQ8MIT7. Positions 24-97.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000013666; ENSMMUP00000012806; ENSMMUG00000009783.

Phylogenomic databases

eggNOGNOG46290.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidQ8MIT7.
OMAGSKCPQK.
OrthoDBEOG7C5MC2.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL11_MACMU
AccessionPrimary (citable) accession number: Q8MIT7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families