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Q8MIT7

- CCL11_MACMU

UniProt

Q8MIT7 - CCL11_MACMU

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Protein

Eotaxin

Gene

CCL11

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity).By similarity

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. mammary duct terminal end bud growth Source: Ensembl
  7. positive regulation of actin filament polymerization Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of Rac GTPase activity Source: Ensembl
  12. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 16

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ8MIT7. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ8MIT7.
SMRiQ8MIT7. Positions 24-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ8MIT7.
OMAiQSYRRIT.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MIT7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR
60 70 80 90
RIISGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP
Length:97
Mass (Da):10,855
Last modified:October 1, 2002 - v1
Checksum:i9BCA0FD6D95B02DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049019 mRNA. Translation: AAL13086.1.
UniGeneiMmu.3651.

Genome annotation databases

EnsembliENSMMUT00000013666; ENSMMUP00000012806; ENSMMUG00000009783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049019 mRNA. Translation: AAL13086.1 .
UniGenei Mmu.3651.

3D structure databases

ProteinModelPortali Q8MIT7.
SMRi Q8MIT7. Positions 24-97.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000013666 ; ENSMMUP00000012806 ; ENSMMUG00000009783 .

Phylogenomic databases

eggNOGi NOG46290.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q8MIT7.
OMAi QSYRRIT.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Gene expression databases

ExpressionAtlasi Q8MIT7. baseline.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of eotaxin/CCL11 and CCR3 from rhesus monkey. Functional expression and characterization of rhesus monkey CCR3 in murine L1-2 cells; generation of antibodies against rhesus CCR3."
    Zhang L., Soares M.P., Guan Y., Sirotina-Meisher A., Matheravidathu S., Iliff S.A., Mudgett J.S., Springer M.S., Daugherty B.L.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL11_MACMU
AccessioniPrimary (citable) accession number: Q8MIT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3