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Q8MIT7

- CCL11_MACMU

UniProt

Q8MIT7 - CCL11_MACMU

Protein

Eotaxin

Gene

CCL11

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 By similarity.By similarity

    GO - Biological processi

    1. branching involved in mammary gland duct morphogenesis Source: Ensembl
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. mammary duct terminal end bud growth Source: Ensembl
    7. positive regulation of actin filament polymerization Source: Ensembl
    8. positive regulation of angiogenesis Source: Ensembl
    9. positive regulation of cell migration Source: Ensembl
    10. positive regulation of endothelial cell proliferation Source: Ensembl
    11. positive regulation of Rac GTPase activity Source: Ensembl
    12. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Small-inducible cytokine A11
    Gene namesi
    Name:CCL11
    Synonyms:SCYA11
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 16

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9774EotaxinPRO_0000005196Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity
    Glycosylationi94 – 941O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MIT7.
    SMRiQ8MIT7. Positions 24-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46290.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ8MIT7.
    OMAiQSYRRIT.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MIT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSTTLLWL LLVAAAFSPQ GLTGPDSVAT TCCFTLTNKK IPLQRLESYR   50
    RIISGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDR KSPTPKP 97
    Length:97
    Mass (Da):10,855
    Last modified:October 1, 2002 - v1
    Checksum:i9BCA0FD6D95B02DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049019 mRNA. Translation: AAL13086.1.
    UniGeneiMmu.3651.

    Genome annotation databases

    EnsembliENSMMUT00000013666; ENSMMUP00000012806; ENSMMUG00000009783.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049019 mRNA. Translation: AAL13086.1 .
    UniGenei Mmu.3651.

    3D structure databases

    ProteinModelPortali Q8MIT7.
    SMRi Q8MIT7. Positions 24-97.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000013666 ; ENSMMUP00000012806 ; ENSMMUG00000009783 .

    Phylogenomic databases

    eggNOGi NOG46290.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q8MIT7.
    OMAi QSYRRIT.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of eotaxin/CCL11 and CCR3 from rhesus monkey. Functional expression and characterization of rhesus monkey CCR3 in murine L1-2 cells; generation of antibodies against rhesus CCR3."
      Zhang L., Soares M.P., Guan Y., Sirotina-Meisher A., Matheravidathu S., Iliff S.A., Mudgett J.S., Springer M.S., Daugherty B.L.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL11_MACMU
    AccessioniPrimary (citable) accession number: Q8MIT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3