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Q8MIQ5 (APOA2_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein A-II

Short name=Apo-AII
Short name=ApoA-II
Alternative name(s):
Apolipoprotein A2

Cleaved into the following 2 chains:

  1. Proapolipoprotein A-II
    Short name=ProapoA-II
  2. Truncated apolipoprotein A-II
Gene names
Name:APOA2
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Subunit structure

Homodimer; disulfide-linked. Interacts with APOA1BP and NDRG1 By similarity. Ref.2

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Sequence similarities

Belongs to the apolipoprotein A2 family.

Mass spectrometry

Molecular mass is 17469.7±1.15 Da from positions 24 - 100. Determined by ESI. Homodimer. Ref.2

Molecular mass is 17342.0 Da from positions 24 - 99. Determined by ESI. Homodimer. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 10082Proapolipoprotein A-II
PRO_0000425358
Chain24 – 10077Apolipoprotein A-II
PRO_0000002010
Chain24 – 9976Truncated apolipoprotein A-II
PRO_0000416582

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid; in Apolipoprotein A-II; in Truncated apolipoprotein A-II By similarity
Modified residue491Methionine sulfoxide By similarity
Modified residue681Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8MIQ5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9037748A340C7B53

FASTA10011,220
        10         20         30         40         50         60 
MKLLAATVLL LTICSLEGAL VRRQAKEPCV DNLVSQYFQT VTDYGKDLME KVKSPELQAE 

        70         80         90        100 
AKSYFEKSKE QLTPLIKKAG TELVNFLSYF MELGTQPATQ 

« Hide

References

[1]"Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample."
Fullerton S.M., Clark A.G., Weiss K.M., Taylor S.L., Stengard J.H., Salomaa V., Boerwinkle E., Nickerson D.A.
Hum. Genet. 111:75-87(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins."
Puppione D.L., Della Donna L., Laganowsky A.D., Bassilian S., Souda P., Ryder O.A., Whitelegge J.P.
Comp. Biochem. Physiol. 4:305-309(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY100525 Genomic DNA. Translation: AAM49808.1.
RefSeqNP_001008976.1. NM_001008976.1.
UniGenePtr.6287.

3D structure databases

ProteinModelPortalQ8MIQ5.
SMRQ8MIQ5. Positions 25-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000002645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID449498.
KEGGptr:449498.

Organism-specific databases

CTD336.

Phylogenomic databases

eggNOGNOG40617.
HOGENOMHOG000033999.
HOVERGENHBG050544.
InParanoidQ8MIQ5.
KOK08758.

Family and domain databases

InterProIPR006801. ApoA-II.
[Graphical view]
PANTHERPTHR11027. PTHR11027. 1 hit.
PfamPF04711. ApoA-II. 1 hit.
[Graphical view]
ProDomPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio20832625.

Entry information

Entry nameAPOA2_PANTR
AccessionPrimary (citable) accession number: Q8MIQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families