Melanin-concentrating hormone receptor subtype 2

Functionⁱ

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Melanin-concentrating hormone receptor subtype 2Imported
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	40 – 60	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	72 – 94	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	114 – 134	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	155 – 172	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	197 – 225	HelicalSequence analysisAdd BLAST	29
Transmembraneⁱ	253 – 274	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	286 – 309	HelicalSequence analysisAdd BLAST	24

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q8MIP5.

PaxDbⁱ

Q8MIP5.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8MIP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 306	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		256

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOGENOMⁱ	HOG000000704.
HOVERGENⁱ	HBG098164.
KEGG Orthology (KO) More...KOⁱ	K05054.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008362. MCH2_receptor. IPR008361. MCH_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR01784. MCH2RECEPTOR. PR01783. MCHRECEPTOR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8MIP5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYSLHSSCWN TSAEPLNKSC NKEFAYHTLS ILDTXRLPSM IGIICSMGLV 
        60         70         80         90        100
GNILIVFTII RSRKKTIPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV 
       110        120        130        140        150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSID RYLALVQPFR LTSWRTRYKT 
       160        170        180        190        200
IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLRYTLY 
       210        220        230        240        250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCYNPS VPKERVMKLT 
       260        270        280        290        300
KMVLVLVAVF ILSAAPYHVI QLVNLKMQQP TLAFHVGYYL SICFSYASSS 
       310        320        330
INPFLYIMLS GNFRKRLPQV QRRVTEKSTI

Length:330

Mass (Da):37,759

Last modified:October 1, 2002 - v1

Checksum:ⁱ4AF3F85621A1CACB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY112659 mRNA. Translation: AAM51852.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001003037.1. NM_001003037.1.
UniGeneⁱ	Cfa.79.

Genome annotation databases

GeneIDⁱ	403562.
KEGGⁱ	cfa:403562.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY112659 mRNA. Translation: AAM51852.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001003037.1. NM_001003037.1.
UniGeneⁱ	Cfa.79.

3D structure databases

ProteinModelPortalⁱ	Q8MIP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PaxDbⁱ	Q8MIP5.

PaxDbⁱ

Q8MIP5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	403562.
KEGGⁱ	cfa:403562.

Organism-specific databases

CTDⁱ	84539.

CTDⁱ

84539.

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOGENOMⁱ	HOG000000704.
HOVERGENⁱ	HBG098164.
KEGG Orthology (KO) More...KOⁱ	K05054.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008362. MCH2_receptor. IPR008361. MCH_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR01784. MCH2RECEPTOR. PR01783. MCHRECEPTOR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8MIP5_CANLF
Accessionⁱ	Q8MIP5Primary (citable) accession number: Q8MIP5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 1, 2002
	Last sequence update:	October 1, 2002
	Last modified:	July 5, 2017
	This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q8MIP5 (Q8MIP5_CANLF)

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Melanin-concentrating hormone receptor subtype 2

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Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8MIP5 (Q8MIP5_CANLF)

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Melanin-concentrating hormone receptor subtype 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ