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Q8MIP0 (FRIH_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain

Short name=Ferritin H subunit
EC=1.16.3.1

Cleaved into the following chain:

  1. Ferritin heavy chain, N-terminally processed
Gene names
Name:FTH1
Synonyms:FTH
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Ferritin heavy chain
PRO_0000252364
Initiator methionine11Removed; alternate By similarity
Chain2 – 182181Ferritin heavy chain, N-terminally processed
PRO_0000424471

Regions

Domain11 – 160150Ferritin-like diiron

Sites

Metal binding281Iron 1 By similarity
Metal binding631Iron 1 By similarity
Metal binding631Iron 2 By similarity
Metal binding661Iron 1 By similarity
Metal binding1081Iron 2 By similarity
Metal binding1421Iron 2 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue21N-acetylthreonine; in Ferritin heavy chain, N-terminally processed By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8MIP0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 2282186D630F1A0D

FASTA18221,269
        10         20         30         40         50         60 
MTTAFPSQVR QNYHQDSEAA INRQINLELH ASYVYLSMSF YFDRDDVALK NFAKYFLHQS 

        70         80         90        100        110        120 
HEEREHAEKL MKLQNQRGGR IFLQDIKKPD QDDWENGLKA MECALHLEKN VNESLLELHK 

       130        140        150        160        170        180 
LATDKNDPHL CDFLETHYLN EQVKAIKELG DHVTNLRRMG APESGMAEYL FDKHTLGECD 


ES 

« Hide

References

[1]Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence analysis of canine and equine ferritin H and L subunit cDNAs."
Orino K., Miura T., Muto S., Watanabe K.
DNA Seq. 16:58-64(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leukocyte and Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY112742 mRNA. Translation: AAM51631.1.
AB175615 mRNA. Translation: BAD96180.1.
AB175616 mRNA. Translation: BAD96181.1.
RefSeqNP_001093883.1. NM_001100413.1.
NP_001238983.1. NM_001252054.1.
XP_001914676.1. XM_001914641.3.
UniGeneEca.13110.
Eca.17740.
Eca.17741.

3D structure databases

ProteinModelPortalQ8MIP0.
SMRQ8MIP0. Positions 7-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000001231.

Proteomic databases

PRIDEQ8MIP0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000001644; ENSECAP00000001231; ENSECAG00000001669.
GeneID100051036.
100062811.
100146482.
KEGGecb:100051036.
ecb:100062811.
ecb:100146482.

Organism-specific databases

CTD2495.

Phylogenomic databases

eggNOGCOG1528.
GeneTreeENSGT00700000104283.
HOGENOMHOG000223383.
HOVERGENHBG000410.
InParanoidQ8MIP0.
KOK00522.
OrthoDBEOG7DRJ49.
TreeFamTF313885.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIH_HORSE
AccessionPrimary (citable) accession number: Q8MIP0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families