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Q8MIP0

- FRIH_HORSE

UniProt

Q8MIP0 - FRIH_HORSE

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Protein
Ferritin heavy chain
Gene
FTH1, FTH
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Iron 1 By similarity
Metal bindingi63 – 631Iron 1 By similarity
Metal bindingi63 – 631Iron 2 By similarity
Metal bindingi66 – 661Iron 1 By similarity
Metal bindingi108 – 1081Iron 2 By similarity
Metal bindingi142 – 1421Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. immune response Source: UniProtKB
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:FTH1
Synonyms:FTH
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 23

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Ferritin heavy chain
PRO_0000252364Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 182181Ferritin heavy chain, N-terminally processed
PRO_0000424471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processed By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ8MIP0.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000001231.

Structurei

3D structure databases

ProteinModelPortaliQ8MIP0.
SMRiQ8MIP0. Positions 7-177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 160150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Phylogenomic databases

eggNOGiCOG1528.
GeneTreeiENSGT00700000104283.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ8MIP0.
KOiK00522.
OrthoDBiEOG7DRJ49.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MIP0-1 [UniParc]FASTAAdd to Basket

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MTTAFPSQVR QNYHQDSEAA INRQINLELH ASYVYLSMSF YFDRDDVALK    50
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD QDDWENGLKA 100
MECALHLEKN VNESLLELHK LATDKNDPHL CDFLETHYLN EQVKAIKELG 150
DHVTNLRRMG APESGMAEYL FDKHTLGECD ES 182
Length:182
Mass (Da):21,269
Last modified:January 23, 2007 - v3
Checksum:i2282186D630F1A0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112742 mRNA. Translation: AAM51631.1.
AB175615 mRNA. Translation: BAD96180.1.
AB175616 mRNA. Translation: BAD96181.1.
RefSeqiNP_001093883.1. NM_001100413.1.
NP_001238983.1. NM_001252054.1.
XP_001914676.1. XM_001914641.3.
UniGeneiEca.13110.
Eca.17740.
Eca.17741.

Genome annotation databases

EnsembliENSECAT00000001644; ENSECAP00000001231; ENSECAG00000001669.
GeneIDi100051036.
100062811.
100146482.
KEGGiecb:100051036.
ecb:100062811.
ecb:100146482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112742 mRNA. Translation: AAM51631.1 .
AB175615 mRNA. Translation: BAD96180.1 .
AB175616 mRNA. Translation: BAD96181.1 .
RefSeqi NP_001093883.1. NM_001100413.1.
NP_001238983.1. NM_001252054.1.
XP_001914676.1. XM_001914641.3.
UniGenei Eca.13110.
Eca.17740.
Eca.17741.

3D structure databases

ProteinModelPortali Q8MIP0.
SMRi Q8MIP0. Positions 7-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000001231.

Proteomic databases

PRIDEi Q8MIP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000001644 ; ENSECAP00000001231 ; ENSECAG00000001669 .
GeneIDi 100051036.
100062811.
100146482.
KEGGi ecb:100051036.
ecb:100062811.
ecb:100146482.

Organism-specific databases

CTDi 2495.

Phylogenomic databases

eggNOGi COG1528.
GeneTreei ENSGT00700000104283.
HOGENOMi HOG000223383.
HOVERGENi HBG000410.
InParanoidi Q8MIP0.
KOi K00522.
OrthoDBi EOG7DRJ49.
TreeFami TF313885.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence analysis of canine and equine ferritin H and L subunit cDNAs."
    Orino K., Miura T., Muto S., Watanabe K.
    DNA Seq. 16:58-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leukocyte and Spleen.

Entry informationi

Entry nameiFRIH_HORSE
AccessioniPrimary (citable) accession number: Q8MIP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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