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Q8MIP0

- FRIH_HORSE

UniProt

Q8MIP0 - FRIH_HORSE

Protein

Ferritin heavy chain

Gene

FTH1

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 2PROSITE-ProRule annotation
    Metal bindingi66 – 661Iron 1PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron 2PROSITE-ProRule annotation
    Metal bindingi142 – 1421Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. immune response Source: UniProtKB
    3. iron ion transport Source: InterPro
    4. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin heavy chain (EC:1.16.3.1)
    Short name:
    Ferritin H subunit
    Cleaved into the following chain:
    Gene namesi
    Name:FTH1
    Synonyms:FTH
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 23

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Ferritin heavy chainPRO_0000252364Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 182181Ferritin heavy chain, N-terminally processedPRO_0000424471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ8MIP0.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000001231.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MIP0.
    SMRiQ8MIP0. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 160150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    GeneTreeiENSGT00700000104283.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiQ8MIP0.
    KOiK00522.
    OrthoDBiEOG7DRJ49.
    TreeFamiTF313885.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8MIP0-1 [UniParc]FASTAAdd to Basket

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    MTTAFPSQVR QNYHQDSEAA INRQINLELH ASYVYLSMSF YFDRDDVALK    50
    NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD QDDWENGLKA 100
    MECALHLEKN VNESLLELHK LATDKNDPHL CDFLETHYLN EQVKAIKELG 150
    DHVTNLRRMG APESGMAEYL FDKHTLGECD ES 182
    Length:182
    Mass (Da):21,269
    Last modified:January 23, 2007 - v3
    Checksum:i2282186D630F1A0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112742 mRNA. Translation: AAM51631.1.
    AB175615 mRNA. Translation: BAD96180.1.
    AB175616 mRNA. Translation: BAD96181.1.
    RefSeqiNP_001093883.1. NM_001100413.1.
    NP_001238983.1. NM_001252054.1.
    XP_001914676.1. XM_001914641.3.
    UniGeneiEca.13110.
    Eca.17740.
    Eca.17741.

    Genome annotation databases

    EnsembliENSECAT00000001644; ENSECAP00000001231; ENSECAG00000001669.
    GeneIDi100051036.
    100062811.
    100146482.
    KEGGiecb:100051036.
    ecb:100062811.
    ecb:100146482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112742 mRNA. Translation: AAM51631.1 .
    AB175615 mRNA. Translation: BAD96180.1 .
    AB175616 mRNA. Translation: BAD96181.1 .
    RefSeqi NP_001093883.1. NM_001100413.1.
    NP_001238983.1. NM_001252054.1.
    XP_001914676.1. XM_001914641.3.
    UniGenei Eca.13110.
    Eca.17740.
    Eca.17741.

    3D structure databases

    ProteinModelPortali Q8MIP0.
    SMRi Q8MIP0. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000001231.

    Proteomic databases

    PRIDEi Q8MIP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000001644 ; ENSECAP00000001231 ; ENSECAG00000001669 .
    GeneIDi 100051036.
    100062811.
    100146482.
    KEGGi ecb:100051036.
    ecb:100062811.
    ecb:100146482.

    Organism-specific databases

    CTDi 2495.

    Phylogenomic databases

    eggNOGi COG1528.
    GeneTreei ENSGT00700000104283.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi Q8MIP0.
    KOi K00522.
    OrthoDBi EOG7DRJ49.
    TreeFami TF313885.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence analysis of canine and equine ferritin H and L subunit cDNAs."
      Orino K., Miura T., Muto S., Watanabe K.
      DNA Seq. 16:58-64(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leukocyte and Spleen.

    Entry informationi

    Entry nameiFRIH_HORSE
    AccessioniPrimary (citable) accession number: Q8MIP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3