Q8MIP0 (FRIH_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin heavy chain
Short name=Ferritin H subunit
EC=1.16.3.1

Gene names

Name:	FTH1
Synonyms:	FTH

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from sequence or structural similarity. Source: UniProtKB iron ion transport Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Ferritin heavy chain		PRO_0000252364
Regions
	Domain	11 – 160	150	Ferritin-like diiron
Sites
	Metal binding	28	1	Iron 1 By similarity
	Metal binding	63	1	Iron 1 By similarity
	Metal binding	63	1	Iron 2 By similarity
	Metal binding	66	1	Iron 1 By similarity
	Metal binding	108	1	Iron 2 By similarity
	Metal binding	142	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MIP0 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2282186D630F1A0D	FASTA	182	21,269
	10 20 30 40 50 60 MTTAFPSQVR QNYHQDSEAA INRQINLELH ASYVYLSMSF YFDRDDVALK NFAKYFLHQS 70 80 90 100 110 120 HEEREHAEKL MKLQNQRGGR IFLQDIKKPD QDDWENGLKA MECALHLEKN VNESLLELHK 130 140 150 160 170 180 LATDKNDPHL CDFLETHYLN EQVKAIKELG DHVTNLRRMG APESGMAEYL FDKHTLGECD ES

References

[1]	Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence analysis of canine and equine ferritin H and L subunit cDNAs." Orino K., Miura T., Muto S., Watanabe K. DNA Seq. 16:58-64(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leukocyte and Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY112742 mRNA. Translation: AAM51631.1. AB175615 mRNA. Translation: BAD96180.1. AB175616 mRNA. Translation: BAD96181.1.
RefSeq	NP_001093883.1. NM_001100413.1. NP_001238983.1. NM_001252054.1. XP_001914676.1. XM_001914641.2.
UniGene	Eca.13110. Eca.16127.
3D structure databases
HSSP	HSSP built from PDB template 2FHA based on UniProtKB P02794.
ProteinModelPortal	Q8MIP0.
SMR	Q8MIP0. Positions 7-177.
ModBase	Search...
Protein-protein interaction databases
STRING	9796.ENSECAP00000001231.
Proteomic databases
PRIDE	Q8MIP0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSECAT00000001644; ENSECAP00000001231; ENSECAG00000001669.
GeneID	100051036. 100062811. 100146482.
KEGG	ecb:100051036. ecb:100062811. ecb:100146482.
Organism-specific databases
CTD	2495.
Phylogenomic databases
eggNOG	COG1528.
GeneTree	ENSGT00700000104283.
HOGENOM	HOG000223383.
HOVERGEN	HBG000410.
InParanoid	Q8MIP0.
KO	K00522.
OrthoDB	EOG47PX78.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR014034. Ferritin_CS. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00540. FERRITIN_1. 1 hit. PS00204. FERRITIN_2. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRIH_HORSE

Accession

Primary (citable) accession number: Q8MIP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program