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Protein

Nuclear receptor subfamily 1 group I member 3

Gene

NR1I3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 8376Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri11 – 3121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 7125NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 3
Alternative name(s):
Constitutive androstane receptor
Short name:
CAR
Gene namesi
Name:NR1I3
Synonyms:CAR
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Recruited to the cytoplasm by DNAJC7.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Nuclear receptor subfamily 1 group I member 3PRO_0000053553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381Phosphothreonine; by PKCBy similarity

Post-translational modificationi

Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000018128.

Interactioni

Subunit structurei

Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023825.

Structurei

3D structure databases

ProteinModelPortaliQ8MIM3.
SMRiQ8MIM3. Positions 103-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 3121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 7125NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ8MIM3.
KOiK08541.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA
60 70 80 90 100
GSCEVSKIQR RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ
110 120 130 140 150
QTPMQLSNEQ EELIQTLLGA HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT
160 170 180 190 200
LAPVLPLVTH FADVNTFMVQ QVIKFTKDLP VFRSLPIEDQ ISLLKGAAVE
210 220 230 240 250
ICHIVLNTTF CLQTQNFLCG PLRYTIEDAA RVSPAVGFQV EFLELLFHFH
260 270 280 290 300
GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRHEIDQLQE EMALTLQSYI
310 320 330 340 350
KGQQQRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI

CS
Length:352
Mass (Da):39,923
Last modified:June 21, 2004 - v2
Checksum:iDC005B3D52962FD4
GO

Sequence cautioni

The sequence AAM76230 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116212 mRNA. Translation: AAM76230.1. Different initiation.
RefSeqiNP_001028068.1. NM_001032896.1.
UniGeneiMmu.3650.

Genome annotation databases

GeneIDi574249.
KEGGimcc:574249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116212 mRNA. Translation: AAM76230.1. Different initiation.
RefSeqiNP_001028068.1. NM_001032896.1.
UniGeneiMmu.3650.

3D structure databases

ProteinModelPortaliQ8MIM3.
SMRiQ8MIM3. Positions 103-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574249.
KEGGimcc:574249.

Organism-specific databases

CTDi9970.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ8MIM3.
KOiK08541.

Gene expression databases

BgeeiENSMMUG00000018128.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR1I3_MACMU
AccessioniPrimary (citable) accession number: Q8MIM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.