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Q8MIL8

- Q8MIL8_PIG

UniProt

Q8MIL8 - Q8MIL8_PIG

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Protein
Submitted name: Epidermal growth factor receptor
Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein tyrosine kinase activity Source: InterPro
  3. transmembrane receptor protein tyrosine kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptorImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ8MIL8.
SMRiQ8MIL8. Positions 25-636, 669-1003.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MIL8-1 [UniParc]FASTAAdd to Basket

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MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS     50
LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP 100
LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF 150
SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW 200
GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV 250
CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS 350
INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE 400
ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL 450
RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK 500
AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV 550
ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA 600
GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI 650
VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 700
QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA 750
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD 800
YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH 850
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY 900
GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC 950
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA 1000
LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV 1050
DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP 1100
AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL 1150
DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA 1200
PASSDLTGA 1209
Length:1,209
Mass (Da):133,532
Last modified:October 1, 2002 - v1
Checksum:i268E3FB11E36F90F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY117054 mRNA. Translation: AAM77472.1.
RefSeqiNP_999172.1. NM_214007.1.
UniGeneiSsc.54725.

Genome annotation databases

GeneIDi397070.
KEGGissc:397070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY117054 mRNA. Translation: AAM77472.1 .
RefSeqi NP_999172.1. NM_214007.1.
UniGenei Ssc.54725.

3D structure databases

ProteinModelPortali Q8MIL8.
SMRi Q8MIL8. Positions 25-636, 669-1003.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397070.
KEGGi ssc:397070.

Organism-specific databases

CTDi 1956.

Phylogenomic databases

HOVERGENi HBG000490.
KOi K04361.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of uterine epidermal growth factor receptor expression during the estrous cycle and early pregnancy in pigs."
    Kim J.G., Vallet J.L., Nonneman D., Christenson R.K.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8MIL8_PIG
AccessioniPrimary (citable) accession number: Q8MIL8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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