UniProtKB - Q8MIL8 (Q8MIL8_PIG)
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Protein
Receptor protein-tyrosine kinase
Gene
N/A
Organism
Sus scrofa (Pig)
Status
Functioni
Catalytic activityi
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 745 | ATPUniRule annotation | 1 | |
Active sitei | 837 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 718 – 726 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- signal transducer, downstream of receptor, with protein tyrosine kinase activity Source: InterPro
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
GO - Biological processi
- transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Organismi | Sus scrofa (Pig)Imported |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 646 – 668 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5004310720 | 22 – 1209 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 1188 |
Proteomic databases
PRIDEi | Q8MIL8. |
PTM databases
iPTMneti | Q8MIL8. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 712 – 979 | Protein kinaseInterPro annotationAdd BLAST | 268 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG1025. Eukaryota. ENOG410XNSR. LUCA. |
HOVERGENi | HBG000490. |
KOi | K04361. |
Family and domain databases
Gene3Di | 3.80.20.20. 2 hits. |
InterProi | View protein in InterPro IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR032778. GF_recep_IV. IPR009030. Growth_fac_rcpt_cys_sf. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR000494. Rcpt_L-dom. IPR036941. Rcpt_L-dom_sf. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt. |
Pfami | View protein in Pfam PF00757. Furin-like. 1 hit. PF14843. GF_recep_IV. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. |
PIRSFi | PIRSF000619. TyrPK_EGF-R. 2 hits. |
PRINTSi | PR00109. TYRKINASE. |
SMARTi | View protein in SMART SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 1 hit. SSF57184. SSF57184. 2 hits. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8MIL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS
60 70 80 90 100
LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP
110 120 130 140 150
LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF
160 170 180 190 200
SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW
210 220 230 240 250
GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE
410 420 430 440 450
ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL
460 470 480 490 500
RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK
510 520 530 540 550
AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV
560 570 580 590 600
ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA
610 620 630 640 650
GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI
660 670 680 690 700
VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN
710 720 730 740 750
QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA
760 770 780 790 800
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD
810 820 830 840 850
YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH
860 870 880 890 900
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY
910 920 930 940 950
GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC
960 970 980 990 1000
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA
1010 1020 1030 1040 1050
LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV
1060 1070 1080 1090 1100
DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP
1110 1120 1130 1140 1150
AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL
1160 1170 1180 1190 1200
DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA
PASSDLTGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY117054 mRNA. Translation: AAM77472.1. |
RefSeqi | NP_999172.1. NM_214007.1. |
UniGenei | Ssc.54725. |
Genome annotation databases
GeneIDi | 397070. |
KEGGi | ssc:397070. |
Similar proteinsi
Entry informationi
Entry namei | Q8MIL8_PIG | |
Accessioni | Q8MIL8Primary (citable) accession number: Q8MIL8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |