Q8MIL8 (Q8MIL8_PIG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Epidermal growth factor receptor EMBL AAM77472.1
Organism	Sus scrofa (Pig) EMBL AAM77472.1
Taxonomic identifier	9823 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	1209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307 Contains protein kinase domain. SAAS SAAS009030

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020635 Nucleotide-binding
Molecular function	Kinase Receptor EMBL AAM77472.1 Transferase Tyrosine-protein kinase RuleBase RU000307 SAAS SAAS020635
PTM	Phosphoprotein SAAS SAAS009030
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: GOC signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral component of membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8MIL8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 268E3FB11E36F90F	FASTA	1,209	133,532
	10 20 30 40 50 60 MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 70 80 90 100 110 120 VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP LENLQIIRGN VLYENTHALA 130 140 150 160 170 180 VLSNYGANKT GLRELPMRNL QEILQGAVRF SNNPALCHAE SIQWRDIVNS DFLSNMSMDF 190 200 210 220 230 240 QSQLGSCPKC DPGCLNGSCW GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC 250 260 270 280 290 300 TGPRESDCLV CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV 310 320 330 340 350 360 VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS INATNIKHFR 370 380 390 400 410 420 NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE ITGFLLIQAW PENRTGLHAF 430 440 450 460 470 480 ENLEIIRGRT KQHGQFSLAV VGLDIASLGL RSLKEISDGD VIVSGNRNLC YANTISWKKL 490 500 510 520 530 540 FGTASQKTKI INNRSEKECK AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN 550 560 570 580 590 600 VLEGEPREFV ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA 610 620 630 640 650 660 GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI VGGLLLAVVL 670 680 690 700 710 720 ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKVKVLGS 730 740 750 760 770 780 GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 790 800 810 820 830 840 CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA 850 860 870 880 890 900 RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY 910 920 930 940 950 960 GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 970 980 990 1000 1010 1020 FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMEDV VDADEYLVPQ 1030 1040 1050 1060 1070 1080 QGFFHSPATS RTPLLSSLSA TSSTPAVACV DRNGQSYPLK EDSFLQRYSS DPTGALTEDS 1090 1100 1110 1120 1130 1140 LDDTFLPAPE YVNQSVPKRP AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT 1150 1160 1170 1180 1190 1200 PRPACINGGL DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA PASSDLTGA

References

[1]	"Characterization of uterine epidermal growth factor receptor expression during the estrous cycle and early pregnancy in pigs." Kim J.G., Vallet J.L., Nonneman D., Christenson R.K. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY117054 mRNA. Translation: AAM77472.1.
RefSeq	NP_999172.1. NM_214007.1.
UniGene	Ssc.54725.
3D structure databases
ProteinModelPortal	Q8MIL8.
SMR	Q8MIL8. Positions 25-636, 669-1003.
ModBase	Search...
MobiDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397070.
KEGG	ssc:397070.
Organism-specific databases
CTD	1956.
Phylogenomic databases
HOVERGEN	HBG000490.
KO	K04361.
Family and domain databases
Gene3D	3.80.20.20. 2 hits.
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt_N_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PIRSF	PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. SSF56112. 1 hit. SSF57184. SSF57184. 2 hits.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8MIL8_PIG

Accession

Primary (citable) accession number: Q8MIL8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)