Receptor protein-tyrosine kinase

Functionⁱ

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	745	ATPUniRule annotation		1
Active siteⁱ	837	Proton acceptorUniRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	718 – 726	ATPUniRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
signal transducer, downstream of receptor, with protein tyrosine kinase activity Source: InterPro
transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Organismⁱ	Sus scrofa (Pig)Imported
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	646 – 668	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_5004310720	22 – 1209	Receptor protein-tyrosine kinaseSequence analysisAdd BLAST		1188

Proteomic databases

PRIDEⁱ	Q8MIL8.

PRIDEⁱ

Q8MIL8.

PTM databases

iPTMnetⁱ	Q8MIL8.

iPTMnetⁱ

Q8MIL8.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q8MIL8. SS.

Genevisibleⁱ

Q8MIL8. SS.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8MIL8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	712 – 979	Protein kinaseInterPro annotationAdd BLAST		268

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1025. Eukaryota. ENOG410XNSR. LUCA.
HOVERGENⁱ	HBG000490.
KEGG Orthology (KO) More...KOⁱ	K04361.

Family and domain databases

Gene3Dⁱ	3.80.20.20. 2 hits.
InterProⁱ	View protein in InterPro IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR032778. GF_recep_IV. IPR009030. Growth_fac_rcpt_cys_sf. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR000494. Rcpt_L-dom. IPR036941. Rcpt_L-dom_sf. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF14843. GF_recep_IV. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits.
PIRSFⁱ	PIRSF000619. TyrPK_EGF-R. 2 hits.
PRINTSⁱ	PR00109. TYRKINASE.
SMARTⁱ	View protein in SMART SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit. SSF57184. SSF57184. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8MIL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS 
        60         70         80         90        100
LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP 
       110        120        130        140        150
LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF 
       160        170        180        190        200
SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW 
       210        220        230        240        250
GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV 
       260        270        280        290        300
CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV 
       310        320        330        340        350
VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS 
       360        370        380        390        400
INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE 
       410        420        430        440        450
ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL 
       460        470        480        490        500
RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK 
       510        520        530        540        550
AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV 
       560        570        580        590        600
ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA 
       610        620        630        640        650
GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI 
       660        670        680        690        700
VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 
       710        720        730        740        750
QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA 
       760        770        780        790        800
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD 
       810        820        830        840        850
YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH 
       860        870        880        890        900
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY 
       910        920        930        940        950
GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC 
       960        970        980        990       1000
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA 
      1010       1020       1030       1040       1050
LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV 
      1060       1070       1080       1090       1100
DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP 
      1110       1120       1130       1140       1150
AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL 
      1160       1170       1180       1190       1200
DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA 

PASSDLTGA

Length:1,209

Mass (Da):133,532

Last modified:October 1, 2002 - v1

Checksum:ⁱ268E3FB11E36F90F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY117054 mRNA. Translation: AAM77472.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_999172.1. NM_214007.1.
UniGeneⁱ	Ssc.54725.

Genome annotation databases

GeneIDⁱ	397070.
KEGGⁱ	ssc:397070.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8MIL8	Q8HY60 Q9N0K4 A5A753	Sus scrofa (Pig)	1,209	UniRef100_Q8MIL8	Cluster: Receptor protein-tyrosine kinase	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8MIL8	F1N7F3 UPI00042CA0E2 Q8HY60 Q9N0K4 A5A753 UPI0002BD0F3D UPI000441AE2A A0A286ZV23 UPI000846D9D5 UPI00095220D6 +19	Bos taurus (Bovine) Bubalus bubalis (Domestic water buffalo) Sus scrofa (Pig) Orcinus orca (Killer whale) Lipotes vexillifer (Yangtze river dolphin) Capra hircus (Goat) Bos indicus (Zebu) Ceratotherium simum simum (southern white rhinoceros) Pantholops hodgsonii (Chiru) (Tibetan antelope) Bos mutus grunniens (Wild yak) (Bos grunniens) And more	1,185	UniRef90_F1N7F3	Cluster: Receptor protein-tyrosine kinase	30

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8MIL8	P00533 UPI00020655C0 UPI0004F43038 UPI0000111E89 UPI0000F24435 F1JTL6 C9JYS6 Q75MF2 H9F140 UPI000180F496 +470	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca mulatta (Rhesus macaque) Rattus norvegicus (Rat) Piliocolobus tephrosceles (Ugandan red Colobus) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	1,210	UniRef50_P00533	Cluster: Epidermal growth factor receptor	481

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY117054 mRNA. Translation: AAM77472.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_999172.1. NM_214007.1.
UniGeneⁱ	Ssc.54725.

3D structure databases

ProteinModelPortalⁱ	Q8MIL8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q8MIL8.

iPTMnetⁱ

Q8MIL8.

Proteomic databases

PRIDEⁱ	Q8MIL8.

PRIDEⁱ

Q8MIL8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	397070.
KEGGⁱ	ssc:397070.

Organism-specific databases

CTDⁱ	1956.

CTDⁱ

1956.

Phylogenomic databases

eggNOGⁱ	KOG1025. Eukaryota. ENOG410XNSR. LUCA.
HOVERGENⁱ	HBG000490.
KEGG Orthology (KO) More...KOⁱ	K04361.

Gene expression databases

Genevisibleⁱ	Q8MIL8. SS.

Genevisibleⁱ

Q8MIL8. SS.

Family and domain databases

Gene3Dⁱ	3.80.20.20. 2 hits.
InterProⁱ	View protein in InterPro IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR032778. GF_recep_IV. IPR009030. Growth_fac_rcpt_cys_sf. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR000494. Rcpt_L-dom. IPR036941. Rcpt_L-dom_sf. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF14843. GF_recep_IV. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits.
PIRSFⁱ	PIRSF000619. TyrPK_EGF-R. 2 hits.
PRINTSⁱ	PR00109. TYRKINASE.
SMARTⁱ	View protein in SMART SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit. SSF57184. SSF57184. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8MIL8_PIG
Accessionⁱ	Q8MIL8Primary (citable) accession number: Q8MIL8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 1, 2002
	Last sequence update:	October 1, 2002
	Last modified:	February 28, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q8MIL8 (Q8MIL8_PIG)

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Receptor protein-tyrosine kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ