Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor protein-tyrosine kinase

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei745ATPUniRule annotation1
Active sitei837Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi718 – 726ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei646 – 668HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500431072022 – 1209Receptor protein-tyrosine kinaseSequence analysisAdd BLAST1188

Proteomic databases

PRIDEiQ8MIL8

PTM databases

iPTMnetiQ8MIL8

Expressioni

Gene expression databases

GenevisibleiQ8MIL8 SS

Structurei

3D structure databases

ProteinModelPortaliQ8MIL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini712 – 979Protein kinaseInterPro annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
HOVERGENiHBG000490
KOiK04361

Family and domain databases

Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 2 hits
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MIL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS
60 70 80 90 100
LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP
110 120 130 140 150
LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF
160 170 180 190 200
SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW
210 220 230 240 250
GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE
410 420 430 440 450
ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL
460 470 480 490 500
RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK
510 520 530 540 550
AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV
560 570 580 590 600
ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA
610 620 630 640 650
GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI
660 670 680 690 700
VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN
710 720 730 740 750
QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA
760 770 780 790 800
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD
810 820 830 840 850
YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH
860 870 880 890 900
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY
910 920 930 940 950
GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC
960 970 980 990 1000
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA
1010 1020 1030 1040 1050
LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV
1060 1070 1080 1090 1100
DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP
1110 1120 1130 1140 1150
AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL
1160 1170 1180 1190 1200
DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA

PASSDLTGA
Length:1,209
Mass (Da):133,532
Last modified:October 1, 2002 - v1
Checksum:i268E3FB11E36F90F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117054 mRNA Translation: AAM77472.1
RefSeqiNP_999172.1, NM_214007.1
UniGeneiSsc.54725

Genome annotation databases

GeneIDi397070
KEGGissc:397070

Similar proteinsi

Entry informationi

Entry nameiQ8MIL8_PIG
AccessioniPrimary (citable) accession number: Q8MIL8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health