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Q8MIL8

- Q8MIL8_PIG

UniProt

Q8MIL8 - Q8MIL8_PIG

Protein
Submitted name:

Epidermal growth factor receptor

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein tyrosine kinase activity Source: InterPro
    3. transmembrane receptor protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Epidermal growth factor receptorImported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MIL8.
    SMRiQ8MIL8. Positions 25-636, 669-1003.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG000490.
    KOiK04361.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8MIL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS     50
    LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP 100
    LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF 150
    SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW 200
    GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV 250
    CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV 300
    VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS 350
    INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE 400
    ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL 450
    RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK 500
    AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV 550
    ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA 600
    GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI 650
    VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 700
    QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA 750
    TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD 800
    YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH 850
    VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY 900
    GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC 950
    WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA 1000
    LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV 1050
    DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP 1100
    AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL 1150
    DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA 1200
    PASSDLTGA 1209
    Length:1,209
    Mass (Da):133,532
    Last modified:October 1, 2002 - v1
    Checksum:i268E3FB11E36F90F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY117054 mRNA. Translation: AAM77472.1.
    RefSeqiNP_999172.1. NM_214007.1.
    UniGeneiSsc.54725.

    Genome annotation databases

    GeneIDi397070.
    KEGGissc:397070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY117054 mRNA. Translation: AAM77472.1 .
    RefSeqi NP_999172.1. NM_214007.1.
    UniGenei Ssc.54725.

    3D structure databases

    ProteinModelPortali Q8MIL8.
    SMRi Q8MIL8. Positions 25-636, 669-1003.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397070.
    KEGGi ssc:397070.

    Organism-specific databases

    CTDi 1956.

    Phylogenomic databases

    HOVERGENi HBG000490.
    KOi K04361.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of uterine epidermal growth factor receptor expression during the estrous cycle and early pregnancy in pigs."
      Kim J.G., Vallet J.L., Nonneman D., Christenson R.K.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8MIL8_PIG
    AccessioniPrimary (citable) accession number: Q8MIL8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)