Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8MIL8 - Q8MIL8_PIG

UniProt

Q8MIL8 - Q8MIL8_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Receptor protein-tyrosine kinase

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein tyrosine kinase activity Source: InterPro
  3. transmembrane receptor protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8MIL8.
SMRiQ8MIL8. Positions 25-636, 669-1003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MIL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRSWAGGAA LLALLAAHFQ ASPALEEKKV CQGTSNKLTQ LGTFEDHFLS 
        60         70         80         90        100
LQRMFNNCEV VLGNLEITYM QNSYNLSFLK TIQEVAGYVL IALNTVEKIP 
       110        120        130        140        150
LENLQIIRGN VLYENTHALA VLSNYGANKT GLRELPMRNL QEILQGAVRF 
       160        170        180        190        200
SNNPALCHAE SIQWRDIVNS DFLSNMSMDF QSQLGSCPKC DPGCLNGSCW 
       210        220        230        240        250
GAGKENCQKL TKVICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV 
       260        270        280        290        300
CRRFRDEATC KDTCPPLMLY NPTTYQMDVN PLGKYSFGAT CVKKCPRNYV 
       310        320        330        340        350
VTDHGSCVRA CSSDSYEVEE DGVRKCKKCD GPCGKVCNGI GIGEFKDTLS 
       360        370        380        390        400
INATNIKHFR NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILKTVKE 
       410        420        430        440        450
ITGFLLIQAW PENRTGLHAF ENLEIIRGRT KQHGQFSLAV VGLDIASLGL 
       460        470        480        490        500
RSLKEISDGD VIVSGNRNLC YANTISWKKL FGTASQKTKI INNRSEKECK 
       510        520        530        540        550
AMGHICNPLC SSEGCWGPEP RDCMSCRNFS RGKECVEKCN VLEGEPREFV 
       560        570        580        590        600
ENAECVQCHP ECLPQAKNVT CMGRGPDSCV RCAHYIDGPH CVKTCPAGIA 
       610        620        630        640        650
GENSTLIWKF ADANHVCHLC HPNCTYGCVG PGLEGCAVDR PKIPSIATGI 
       660        670        680        690        700
VGGLLLAVVL ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 
       710        720        730        740        750
QALLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA 
       760        770        780        790        800
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD 
       810        820        830        840        850
YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH 
       860        870        880        890        900
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW LALESILHRV YTHQSDVWSY 
       910        920        930        940        950
GVTVWELMTF GSKPYDGIPA SEISTVLEKG ERLPQPPICT IDVYMIMVKC 
       960        970        980        990       1000
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA 
      1010       1020       1030       1040       1050
LMDEEDMEDV VDADEYLVPQ QGFFHSPATS RTPLLSSLSA TSSTPAVACV 
      1060       1070       1080       1090       1100
DRNGQSYPLK EDSFLQRYSS DPTGALTEDS LDDTFLPAPE YVNQSVPKRP 
      1110       1120       1130       1140       1150
AGSVQNPVYH NQPLSAAPGR DPHYQNSHSN AVGNPEYLNT PRPACINGGL 
      1160       1170       1180       1190       1200
DGPAFWAQTG SHQINLDNPD YQQAFFPKEA KSNGICKGPA AENAEYLRAA 

PASSDLTGA
Length:1,209
Mass (Da):133,532
Last modified:October 1, 2002 - v1
Checksum:i268E3FB11E36F90F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117054 mRNA. Translation: AAM77472.1.
RefSeqiNP_999172.1. NM_214007.1.
UniGeneiSsc.54725.

Genome annotation databases

GeneIDi397070.
KEGGissc:397070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117054 mRNA. Translation: AAM77472.1.
RefSeqiNP_999172.1. NM_214007.1.
UniGeneiSsc.54725.

3D structure databases

ProteinModelPortaliQ8MIL8.
SMRiQ8MIL8. Positions 25-636, 669-1003.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397070.
KEGGissc:397070.

Organism-specific databases

CTDi1956.

Phylogenomic databases

HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of uterine epidermal growth factor receptor expression during the estrous cycle and early pregnancy in pigs."
    Kim J.G., Vallet J.L., Nonneman D., Christenson R.K.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8MIL8_PIG
AccessioniPrimary (citable) accession number: Q8MIL8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.