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Q8MIF7

- PGK2_HORSE

UniProt

Q8MIF7 - PGK2_HORSE

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Protein
Phosphoglycerate kinase 2
Gene
PGK2
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei313 – 3131ATP; via carbonyl oxygen By similarity
Binding sitei344 – 3441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 2 (EC:2.7.2.3)
Alternative name(s):
Phosphoglycerate kinase, testis specific
Gene namesi
Name:PGK2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Phosphoglycerate kinase 2UniRule annotation
PRO_0000145830Add
BLAST

Proteomic databases

PRIDEiQ8MIF7.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8MIF7.
SMRiQ8MIF7. Positions 2-417.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008177.
KOiK00927.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MIF7-1 [UniParc]FASTAAdd to Basket

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MSLSKKLTLD KLDVKGKRII MRVDFNVPMK KNQITNNQRI KASIPSIKYC    50
LDNGARSVVL MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV 100
GSEVEKACAN PATGSVILLE NLRFHVEEEG KGQDPSGNKL KAEAGKIEAF 150
RASLSKLGDV YVNDAFGTAH RAHSSMVGIN LPQKASGFLM KKELEYFAKA 200
LENPERPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM AYTFLKVLNN 250
MEIGASLFDE EGAKIVKDIM AKANKNGVRI TFPVDFVTAD KFEENAKVGQ 300
ATVASGIPAG WMGLDCGPET NKKYAQVMAQ AKLIVWNGPV GVFEWDAFAK 350
GTKALMDEIV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
ELLEGKILPG VDALSNL 417
Length:417
Mass (Da):44,879
Last modified:January 23, 2007 - v3
Checksum:i5AA58A6CF3685392
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315378 Genomic DNA. Translation: CAD43034.1.
RefSeqiNP_001077063.1. NM_001083594.1.
UniGeneiEca.13389.

Genome annotation databases

GeneIDi100036552.
KEGGiecb:100036552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315378 Genomic DNA. Translation: CAD43034.1 .
RefSeqi NP_001077063.1. NM_001083594.1.
UniGenei Eca.13389.

3D structure databases

ProteinModelPortali Q8MIF7.
SMRi Q8MIF7. Positions 2-417.
ModBasei Search...

Proteomic databases

PRIDEi Q8MIF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100036552.
KEGGi ecb:100036552.

Organism-specific databases

CTDi 5232.

Phylogenomic databases

HOVERGENi HBG008177.
KOi K00927.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGK2_HORSE
AccessioniPrimary (citable) accession number: Q8MIF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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