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Q8MIF7 (PGK2_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase 2

EC=2.7.2.3
Alternative name(s):
Phosphoglycerate kinase, testis specific
Gene names
Name:PGK2
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphoglycerate kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Phosphoglycerate kinase 2 HAMAP-Rule MF_00145
PRO_0000145830

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8MIF7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5AA58A6CF3685392

FASTA41744,879
        10         20         30         40         50         60 
MSLSKKLTLD KLDVKGKRII MRVDFNVPMK KNQITNNQRI KASIPSIKYC LDNGARSVVL 

        70         80         90        100        110        120 
MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV GSEVEKACAN PATGSVILLE 

       130        140        150        160        170        180 
NLRFHVEEEG KGQDPSGNKL KAEAGKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGIN 

       190        200        210        220        230        240 
LPQKASGFLM KKELEYFAKA LENPERPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM 

       250        260        270        280        290        300 
AYTFLKVLNN MEIGASLFDE EGAKIVKDIM AKANKNGVRI TFPVDFVTAD KFEENAKVGQ 

       310        320        330        340        350        360 
ATVASGIPAG WMGLDCGPET NKKYAQVMAQ AKLIVWNGPV GVFEWDAFAK GTKALMDEIV 

       370        380        390        400        410 
KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKILPG VDALSNL 

« Hide

References

[1]"Molecular characterization of the equine AEG1 locus."
Giese A., Jude R., Kuiper H., Piumi F., Schambony A., Guerin G., Distl O., Topfer-Petersen E., Leeb T.
Gene 292:65-72(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315378 Genomic DNA. Translation: CAD43034.1.
RefSeqNP_001077063.1. NM_001083594.1.
UniGeneEca.13389.

3D structure databases

ProteinModelPortalQ8MIF7.
SMRQ8MIF7. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8MIF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100036552.
KEGGecb:100036552.

Organism-specific databases

CTD5232.

Phylogenomic databases

HOVERGENHBG008177.
KOK00927.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK2_HORSE
AccessionPrimary (citable) accession number: Q8MIF7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways