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Q8MIF7

- PGK2_HORSE

UniProt

Q8MIF7 - PGK2_HORSE

Protein

Phosphoglycerate kinase 2

Gene

PGK2

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei220 – 2201ATPBy similarity
    Binding sitei313 – 3131ATP; via carbonyl oxygenBy similarity
    Binding sitei344 – 3441ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi373 – 3764ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase 2 (EC:2.7.2.3)
    Alternative name(s):
    Phosphoglycerate kinase, testis specific
    Gene namesi
    Name:PGK2
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Phosphoglycerate kinase 2PRO_0000145830Add
    BLAST

    Proteomic databases

    PRIDEiQ8MIF7.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MIF7.
    SMRiQ8MIF7. Positions 2-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    HOVERGENiHBG008177.
    KOiK00927.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8MIF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSKKLTLD KLDVKGKRII MRVDFNVPMK KNQITNNQRI KASIPSIKYC    50
    LDNGARSVVL MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV 100
    GSEVEKACAN PATGSVILLE NLRFHVEEEG KGQDPSGNKL KAEAGKIEAF 150
    RASLSKLGDV YVNDAFGTAH RAHSSMVGIN LPQKASGFLM KKELEYFAKA 200
    LENPERPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM AYTFLKVLNN 250
    MEIGASLFDE EGAKIVKDIM AKANKNGVRI TFPVDFVTAD KFEENAKVGQ 300
    ATVASGIPAG WMGLDCGPET NKKYAQVMAQ AKLIVWNGPV GVFEWDAFAK 350
    GTKALMDEIV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
    ELLEGKILPG VDALSNL 417
    Length:417
    Mass (Da):44,879
    Last modified:January 23, 2007 - v3
    Checksum:i5AA58A6CF3685392
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315378 Genomic DNA. Translation: CAD43034.1.
    RefSeqiNP_001077063.1. NM_001083594.1.
    UniGeneiEca.13389.

    Genome annotation databases

    GeneIDi100036552.
    KEGGiecb:100036552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315378 Genomic DNA. Translation: CAD43034.1 .
    RefSeqi NP_001077063.1. NM_001083594.1.
    UniGenei Eca.13389.

    3D structure databases

    ProteinModelPortali Q8MIF7.
    SMRi Q8MIF7. Positions 2-417.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8MIF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100036552.
    KEGGi ecb:100036552.

    Organism-specific databases

    CTDi 5232.

    Phylogenomic databases

    HOVERGENi HBG008177.
    KOi K00927.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPGK2_HORSE
    AccessioniPrimary (citable) accession number: Q8MIF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3