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Protein

Neuropeptide W

Gene

NPW

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
PPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Alternative name(s):
L8
Neuropeptide W-30
Short name:
NPW30
Alternative name(s):
L8C
Gene namesi
Name:NPW
Synonyms:PPL8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
PeptideiPRO_000001984633 – 62Neuropeptide W-30Add BLAST30
PeptideiPRO_000001984733 – 55Neuropeptide W-23Add BLAST23
PropeptideiPRO_000001984865 – 152Sequence analysisAdd BLAST88

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8MI35.
PRIDEiQ8MI35.

Expressioni

Gene expression databases

BgeeiENSSSCG00000008037.
GenevisibleiQ8MI35. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008582.

Structurei

3D structure databases

SMRiQ8MI35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7Z8. Eukaryota.
ENOG41115MZ. LUCA.
HOGENOMiHOG000113846.
HOVERGENiHBG039581.
InParanoidiQ8MI35.
OMAiLPSGAWY.
OrthoDBiEOG091G0QS9.
TreeFamiTF333179.

Family and domain databases

InterProiView protein in InterPro
IPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
PANTHERiPTHR28553. PTHR28553. 1 hit.
PfamiView protein in Pfam
PF15180. NPBW. 1 hit.
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD601995. Neuropept_W_pre. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MI35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARGPGPGA TARRRLLALL LLLLLLPLPA RAWYKHTASP RYHTVGRAAG
60 70 80 90 100
LLMGLRRSPY MWRRALRPAA GPLAWDTFGQ DVPPRGPSAR NALSPGPAPR
110 120 130 140 150
DAPLLPPGVQ TLWQVRRGSF RSGIPVSAPR SPRARGSEPQ PELGASSWTS

AE
Length:152
Mass (Da):16,347
Last modified:October 1, 2002 - v1
Checksum:i454284DD448067E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084277 mRNA. Translation: BAC07173.1.
RefSeqiNP_998951.1. NM_213786.1.
UniGeneiSsc.15796.

Genome annotation databases

GeneIDi396680.
KEGGissc:396680.

Similar proteinsi

Entry informationi

Entry nameiNPW_PIG
AccessioniPrimary (citable) accession number: Q8MI35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families