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Protein

Neuropeptide W

Gene

NPW

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
PPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Alternative name(s):
L8
Neuropeptide W-30
Short name:
NPW30
Alternative name(s):
L8C
Gene namesi
Name:NPW
Synonyms:PPL8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Peptidei33 – 6230Neuropeptide W-30PRO_0000019846Add
BLAST
Peptidei33 – 5523Neuropeptide W-23PRO_0000019847Add
BLAST
Propeptidei65 – 15288Sequence analysisPRO_0000019848Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8MI35.

Expressioni

Gene expression databases

GenevisibleiQ8MI35. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008582.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7Z8. Eukaryota.
ENOG41115MZ. LUCA.
GeneTreeiENSGT00510000049904.
HOGENOMiHOG000113846.
HOVERGENiHBG039581.
InParanoidiQ8MI35.
OMAiLPSGAWY.
OrthoDBiEOG7XDBHT.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8MI35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARGPGPGA TARRRLLALL LLLLLLPLPA RAWYKHTASP RYHTVGRAAG
60 70 80 90 100
LLMGLRRSPY MWRRALRPAA GPLAWDTFGQ DVPPRGPSAR NALSPGPAPR
110 120 130 140 150
DAPLLPPGVQ TLWQVRRGSF RSGIPVSAPR SPRARGSEPQ PELGASSWTS

AE
Length:152
Mass (Da):16,347
Last modified:October 1, 2002 - v1
Checksum:i454284DD448067E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084277 mRNA. Translation: BAC07173.1.
RefSeqiNP_998951.1. NM_213786.1.
UniGeneiSsc.15796.

Genome annotation databases

EnsembliENSSSCT00000008806; ENSSSCP00000008582; ENSSSCG00000008037.
GeneIDi396680.
KEGGissc:396680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084277 mRNA. Translation: BAC07173.1.
RefSeqiNP_998951.1. NM_213786.1.
UniGeneiSsc.15796.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008582.

Proteomic databases

PaxDbiQ8MI35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008806; ENSSSCP00000008582; ENSSSCG00000008037.
GeneIDi396680.
KEGGissc:396680.

Organism-specific databases

CTDi283869.

Phylogenomic databases

eggNOGiENOG410J7Z8. Eukaryota.
ENOG41115MZ. LUCA.
GeneTreeiENSGT00510000049904.
HOGENOMiHOG000113846.
HOVERGENiHBG039581.
InParanoidiQ8MI35.
OMAiLPSGAWY.
OrthoDBiEOG7XDBHT.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiQ8MI35. SS.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8."
    Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.
    J. Biol. Chem. 277:35826-35832(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 33-52, SYNTHESIS OF NPW23 AND NPW30.

Entry informationi

Entry nameiNPW_PIG
AccessioniPrimary (citable) accession number: Q8MI35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.