ID   AL1A1_RABIT             Reviewed;         496 AA.
AC   Q8MI17;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Retinal dehydrogenase 1;
DE            Short=RALDH 1;
DE            Short=RalDH1;
DE            EC=1.2.1.36;
DE   AltName: Full=Aldehyde dehydrogenase family 1 member A1;
DE   AltName: Full=Aldehyde dehydrogenase, cytosolic;
DE   AltName: Full=ALHDII;
DE   AltName: Full=ALDH-E1;
GN   Name=ALDH1A1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cornea;
RX   PubMed=12941160; DOI=10.1089/104454903322216671;
RA   Manzer R., Qamar L., Estey T., Pappa A., Petersen D.R., Vasiliou V.;
RT   "Molecular cloning and baculovirus expression of the rabbit corneal
RT   aldehyde dehydrogenase (ALDH1A1) cDNA.";
RL   DNA Cell Biol. 22:329-338(2003).
CC   -!- FUNCTION: Can convert/oxidize retinaldehyde to retinoic acid (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Retinal + NAD(+) + H(2)O = retinoate + NADH.
CC   -!- PATHWAY: Cofactor metabolism; retinol metabolism.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AY038801; AAK72097.1; -; mRNA.
DR   UniGene; Ocu.1307; -.
DR   HSSP; P51977; 1BXS.
DR   HOVERGEN; Q8MI17; -.
DR   BRENDA; 1.2.1.36; 255.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001758; F:retinal dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN         1    496       Retinal dehydrogenase 1.
FT                                /FTId=PRO_0000056418.
FT   NP_BIND     241    246       NAD (By similarity).
FT   ACT_SITE    264    264       Proton acceptor (By similarity).
FT   ACT_SITE    298    298       Nucleophile (By similarity).
FT   SITE        165    165       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   496 AA;  54341 MW;  4BD963CF015FD164 CRC64;
     MADLPTPLTN LKIQYTKIFI NNEWHDSVSG KKFPVLNPAT EEQICLIEEG DKADVDKAVK
     AARQAFQIGS PWRTMDASER GRLLYKLADL IERDRLLLAT MESLNAGKLF PNAYLMDLGG
     CIKTLRYCAG WADKIQGRTM PMDGDFFCYT RHEPVGVCGQ IIPWNFPLVM LIWKIGPALS
     CGNTVIVKPA EQTPLTALHV ASLIKEAGFP PGVVNIVPGY GPTAGAAISS HMDIDKVAFT
     GSTEVGKLIK EAAGKSNLKR VTLELGGKSP CIVFADADLD NAVEFAHQGV FYHQGQCCIA
     ASRLFVEESI YDEFVRRSVE RAKKYVLGNP LAPEVNQGPQ IDKEQYNKIL DLIESGKKEG
     AKLECGGGPW GNKGYFIQPT VFSNVTDEMR IAKEEIFGPV QQIMKFKSLD DVIKRANNTT
     YGLSAGIFTK DLDKAVTVSS ALQAGTVWVN CYSVVSAQVP FGGFKMSGNG RELGEYGLQQ
     YTEVKTVTVK ISQKNS
//