Reviewed, UniProtKB/Swiss-Prot Q8MI17 (AL1A1_RABIT)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 1
      Short name=RALDH 1
      Short name=RalDH1
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A1
    Aldehyde dehydrogenase, cytosolic
    ALHDII
    ALDH-E1

Gene names

Name:

ALDH1A1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can convert/oxidize retinaldehyde to retinoic acid By similarity.
Catalytic activity	Retinal + NAD+ + H2O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Retinal dehydrogenase 1		PRO_0000056418
Regions
	Nucleotide binding	241 – 246	6	NAD By similarity
Sites
	Active site	264	1	Proton acceptor By similarity
	Active site	298	1	Nucleophile By similarity
	Site	165	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8MI17-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4BD963CF015FD164	FASTA	496	54,341
	10 20 30 40 50 60 MADLPTPLTN LKIQYTKIFI NNEWHDSVSG KKFPVLNPAT EEQICLIEEG DKADVDKAVK 70 80 90 100 110 120 AARQAFQIGS PWRTMDASER GRLLYKLADL IERDRLLLAT MESLNAGKLF PNAYLMDLGG 130 140 150 160 170 180 CIKTLRYCAG WADKIQGRTM PMDGDFFCYT RHEPVGVCGQ IIPWNFPLVM LIWKIGPALS 190 200 210 220 230 240 CGNTVIVKPA EQTPLTALHV ASLIKEAGFP PGVVNIVPGY GPTAGAAISS HMDIDKVAFT 250 260 270 280 290 300 GSTEVGKLIK EAAGKSNLKR VTLELGGKSP CIVFADADLD NAVEFAHQGV FYHQGQCCIA 310 320 330 340 350 360 ASRLFVEESI YDEFVRRSVE RAKKYVLGNP LAPEVNQGPQ IDKEQYNKIL DLIESGKKEG 370 380 390 400 410 420 AKLECGGGPW GNKGYFIQPT VFSNVTDEMR IAKEEIFGPV QQIMKFKSLD DVIKRANNTT 430 440 450 460 470 480 YGLSAGIFTK DLDKAVTVSS ALQAGTVWVN CYSVVSAQVP FGGFKMSGNG RELGEYGLQQ 490 YTEVKTVTVK ISQKNS

References

[1]	"Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA." Manzer R., Qamar L., Estey T., Pappa A., Petersen D.R., Vasiliou V. DNA Cell Biol. 22:329-338(2003) [PubMed: 12941160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cornea.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY038801 mRNA. Translation: AAK72097.1.
UniGene	Ocu.1307
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q8MI17.
Enzyme and pathway databases
BRENDA	1.2.1.36. 255.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A1_RABIT

Accession

Primary (citable) accession number: Q8MI17

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)