ID   URIC_MACFA              Reviewed;         304 AA.
AC   Q8MHW6;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=Uricase;
DE            EC=1.7.3.3;
DE   AltName: Full=Urate oxidase;
GN   Name=UOX;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   MEDLINE=21959327; PubMed=11961098;
RA   Oda M., Satta Y., Takenaka O., Takahata N.;
RT   "Loss of urate oxidase activity in hominoids and its evolutionary
RT   implications.";
RL   Mol. Biol. Evol. 19:640-653(2002).
CC   -!- FUNCTION: Catalyzes the oxidation of uric acid to 5-
CC       hydroxyisourate, which spontaneously decomposes to form allantoin.
CC   -!- CATALYTIC ACTIVITY: Urate + O(2) + H(2)O = 5-hydroxyisourate +
CC       H(2)O(2).
CC   -!- PATHWAY: Purine metabolism; uric acid degradation; (S)-allantoin
CC       from uric acid: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the uricase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB074382; BAB91556.1; -; Genomic_DNA.
DR   HSSP; Q00511; 1R51.
DR   HOVERGEN; Q8MHW6; -.
DR   BRENDA; 1.7.3.3; 3438.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004846; F:urate oxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002042; Uricase.
DR   InterPro; IPR019842; Uricase_CS.
DR   Gene3D; G3DSA:3.10.270.10; Uricase; 1.
DR   PANTHER; PTHR10395:SF1; Uricase; 1.
DR   Pfam; PF01014; Uricase; 2.
DR   PRINTS; PR00093; URICASE.
DR   ProDom; PD003367; Uricase; 2.
DR   TIGRFAMs; TIGR03383; urate_oxi; 1.
DR   PROSITE; PS00366; URICASE; 1.
PE   3: Inferred from homology;
KW   Acetylation; Oxidoreductase; Peroxisome; Phosphoprotein;
KW   Purine metabolism.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    304       Uricase.
FT                                /FTId=PRO_0000165984.
FT   REGION      235    236       Substrate binding (By similarity).
FT   MOTIF       302    304       Microbody targeting signal (Potential).
FT   ACT_SITE    187    187       Charge relay system (By similarity).
FT   ACT_SITE    236    236       Charge relay system (By similarity).
FT   BINDING      68     68       Substrate (By similarity).
FT   BINDING     187    187       Substrate (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   MOD_RES      36     36       N6-acetyllysine (By similarity).
FT   MOD_RES      39     39       Phosphoserine (By similarity).
FT   MOD_RES      55     55       N6-acetyllysine (By similarity).
FT   MOD_RES     118    118       N6-acetyllysine (By similarity).
FT   MOD_RES     122    122       N6-acetyllysine (By similarity).
FT   MOD_RES     164    164       N6-acetyllysine (By similarity).
FT   MOD_RES     185    185       N6-acetyllysine (By similarity).
FT   MOD_RES     221    221       N6-acetyllysine (By similarity).
FT   MOD_RES     228    228       N6-acetyllysine (By similarity).
FT   MOD_RES     232    232       Phosphoserine (By similarity).
FT   MOD_RES     278    278       N6-acetyllysine (By similarity).
FT   MOD_RES     291    291       N6-acetyllysine (By similarity).
FT   MOD_RES     302    302       Phosphoserine (By similarity).
SQ   SEQUENCE   304 AA;  34978 MW;  D320AFF27870FAE5 CRC64;
     MADYHNNYKK NDELEFVRTG YGKDMVKVLH IQRDGKYHSI KEVATSVQLT LSSKKDYLHG
     DNSDIIPTDT IKNTVHVLAK FKGIKSIEAF GVNICEYFLS SFNHVIRAQV YVEEIPWKRL
     EKNGVKHVHA FIHTPTGTHF CEVEQLRSGP PVIHSGIKDL KVLKTTQSGF EGFIKDQFTT
     LPEVKDRCFA TQVYCKWRYH QCRDVDFEAT WGTIRDLVLE KFAGPYDKGE YSPSVQKTLY
     DIQVLSLSRV PEIEDMEISL PNIHYFNIDM SKMGLINKEE VLLPLDNPYG KITGTVKRKL
     SSRL
//