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Protein
Submitted name:

Histocompatibility 2, M region locus 3

Gene

H2-M3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. alpha-beta T cell activation involved in immune response Source: MGI
  2. antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: MGI
  3. antigen processing and presentation of exogenous peptide antigen via MHC class Ib Source: MGI
  4. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
  5. antigen processing and presentation of peptide antigen via MHC class I Source: GO_Central
  6. defense response to bacterium Source: MGI
  7. immune response-inhibiting cell surface receptor signaling pathway Source: MGI
  8. negative regulation of dendritic cell differentiation Source: MGI
  9. negative regulation of T cell proliferation Source: MGI
  10. positive regulation of interferon-gamma production Source: MGI
  11. positive regulation of interleukin-12 production Source: MGI
  12. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
  13. positive regulation of nitric oxide biosynthetic process Source: MGI
  14. positive regulation of regulatory T cell differentiation Source: MGI
  15. positive regulation of T cell mediated cytotoxicity Source: MGI
  16. positive regulation of T cell tolerance induction Source: MGI
  17. response to molecule of bacterial origin Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Histocompatibility 2, M region locus 3Imported
Gene namesi
Name:H2-M3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95915. H2-M3.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
  4. MHC class Ib protein complex Source: MGI
  5. MHC class I protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8MHM0.

Structurei

3D structure databases

ProteinModelPortaliQ8MHM0.
SMRiQ8MHM0. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MHM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSNCALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG
60 70 80 90 100
YVDDMQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA
110 120 130 140 150
NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL
160 170 180 190 200
NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK
210 220 230 240 250
EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ
260 270 280 290 300
DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR
310 320 330
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER
Length:336
Mass (Da):37,835
Last modified:October 1, 2002 - v1
Checksum:iCA9C82B3DE8A483A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031984 mRNA. Translation: AAH31984.1.
UniGeneiMm.14437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031984 mRNA. Translation: AAH31984.1.
UniGeneiMm.14437.

3D structure databases

ProteinModelPortaliQ8MHM0.
SMRiQ8MHM0. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95915. H2-M3.

Phylogenomic databases

HOVERGENiHBG016709.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8MHM0.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary tumor metastatized to lung. MMTV-LTR/Wnt1 model. Expression driven by an MMTV-LTR enhancer.Imported.

Entry informationi

Entry nameiQ8MHM0_MOUSE
AccessioniPrimary (citable) accession number: Q8MHM0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.