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Q8MHM0 (Q8MHM0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:H2-M3 EMBL AAH31984.1 MGI 95915
OrganismMus musculus (Mouse) EMBL AAH31984.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the MHC class I family. RuleBase RU004439

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS027648

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS011161
   PTMDisulfide bond SAAS SAAS011162
Gene Ontology (GO)
   Biological_processalpha-beta T cell activation involved in immune response

Inferred from mutant phenotype PubMed 16476767. Source: MGI

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

Inferred from direct assay PubMed 8464890. Source: MGI

antigen processing and presentation of exogenous peptide antigen via MHC class Ib

Inferred from direct assay PubMed 16461341. Source: MGI

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Inferred from direct assay PubMed 16299293. Source: MGI

antigen processing and presentation of peptide antigen via MHC class I

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to bacterium

Inferred from direct assay PubMed 16461341PubMed 16476767. Source: MGI

positive regulation of T cell mediated cytotoxicity

Inferred from direct assay PubMed 16299293PubMed 16461341PubMed 16476767PubMed 8464890. Source: MGI

positive regulation of interferon-gamma production

Inferred from mutant phenotype PubMed 16476767. Source: MGI

positive regulation of natural killer cell mediated cytotoxicity

Inferred from mutant phenotype PubMed 16476767. Source: MGI

positive regulation of nitric oxide biosynthetic process

Inferred from mutant phenotype PubMed 16476767. Source: MGI

response to molecule of bacterial origin

Inferred from direct assay PubMed 16299293. Source: MGI

   Cellular_componentMHC class I protein complex

Inferred from electronic annotation. Source: InterPro

MHC class Ib protein complex

Inferred from direct assay PubMed 8464890. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 16476767PubMed 8464890. Source: MGI

   Molecular_functionpeptide antigen binding

Inferred from direct assay PubMed 16461341PubMed 16476767PubMed 8464890. Source: MGI

receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8MHM0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CA9C82B3DE8A483A

FASTA33637,835
        10         20         30         40         50         60 
MGSSSNCALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG YVDDMQFQRC 

        70         80         90        100        110        120 
DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA NLRTLLRYYN QSEGGSHILQ 

       130        140        150        160        170        180 
WMVSCEVGPD MRLLGAHYQA AYDGSDYITL NEDLSSWTAV DMVSQITKSR LESAGTAEYF 

       190        200        210        220        230        240 
RAYVEGECLE LLHRFLRNGK EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT 

       250        260        270        280        290        300 
WQKDEEDLTQ DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR 

       310        320        330 
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II EMBL AAH31984.1.
Tissue: Mammary tumor metastatized to lung. MMTV-LTR/Wnt1 model. Expression driven by an MMTV-LTR enhancer. EMBL AAH31984.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC031984 mRNA. Translation: AAH31984.1.
UniGeneMm.14437.

3D structure databases

ProteinModelPortalQ8MHM0.
SMRQ8MHM0. Positions 25-298.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95915. H2-M3.

Phylogenomic databases

HOVERGENHBG016709.
InParanoidQ8MHM0.

Gene expression databases

GenevestigatorQ8MHM0.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8MHM0_MOUSE
AccessionPrimary (citable) accession number: Q8MHM0
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)