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Q8MHM0

- Q8MHM0_MOUSE

UniProt

Q8MHM0 - Q8MHM0_MOUSE

Protein
Submitted name:

Histocompatibility 2, M region locus 3

Gene

H2-M3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI

    GO - Biological processi

    1. alpha-beta T cell activation involved in immune response Source: MGI
    2. antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: MGI
    3. antigen processing and presentation of exogenous peptide antigen via MHC class Ib Source: MGI
    4. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
    5. antigen processing and presentation of peptide antigen via MHC class I Source: InterPro
    6. defense response to bacterium Source: MGI
    7. positive regulation of interferon-gamma production Source: MGI
    8. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
    9. positive regulation of nitric oxide biosynthetic process Source: MGI
    10. positive regulation of T cell mediated cytotoxicity Source: MGI
    11. response to molecule of bacterial origin Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histocompatibility 2, M region locus 3Imported
    Gene namesi
    Name:H2-M3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95915. H2-M3.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. MHC class Ib protein complex Source: MGI
    4. MHC class I protein complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8MHM0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MHM0.
    SMRiQ8MHM0. Positions 25-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiQ8MHM0.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8MHM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSSNCALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG    50
    YVDDMQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA 100
    NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL 150
    NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK 200
    EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ 250
    DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR 300
    SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER 336
    Length:336
    Mass (Da):37,835
    Last modified:October 1, 2002 - v1
    Checksum:iCA9C82B3DE8A483A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031984 mRNA. Translation: AAH31984.1.
    UniGeneiMm.14437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031984 mRNA. Translation: AAH31984.1 .
    UniGenei Mm.14437.

    3D structure databases

    ProteinModelPortali Q8MHM0.
    SMRi Q8MHM0. Positions 25-298.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95915. H2-M3.

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi Q8MHM0.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8MHM0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary tumor metastatized to lung. MMTV-LTR/Wnt1 model. Expression driven by an MMTV-LTR enhancer.Imported.

    Entry informationi

    Entry nameiQ8MHM0_MOUSE
    AccessioniPrimary (citable) accession number: Q8MHM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)