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Protein
Submitted name:

Histocompatibility 2, M region locus 3

Gene

H2-M3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Histocompatibility 2, M region locus 3Imported
Gene namesi
Name:H2-M3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95915. H2-M3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500431068026 – 336Sequence analysisAdd BLAST311

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ8MHM0.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8MHM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410KII2. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8MHM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSNCALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG
60 70 80 90 100
YVDDMQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA
110 120 130 140 150
NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL
160 170 180 190 200
NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK
210 220 230 240 250
EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ
260 270 280 290 300
DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR
310 320 330
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER
Length:336
Mass (Da):37,835
Last modified:October 1, 2002 - v1
Checksum:iCA9C82B3DE8A483A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031984 mRNA. Translation: AAH31984.1.
UniGeneiMm.14437.

Similar proteinsi

Entry informationi

Entry nameiQ8MHM0_MOUSE
AccessioniPrimary (citable) accession number: Q8MHM0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)