Q8MH63 (LAT1N_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative L-type amino acid transporter 1-like protein MLAS

Alternative name(s):
hLAT1 3-transmembrane protein MLAS
Short name=hLAT1 3TM MLAS

Gene names

Name:	SLC7A5P1
Synonyms:	MLAS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines. Ref.1
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	amino acid transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Putative L-type amino acid transporter 1-like protein MLAS		PRO_0000348251
Regions
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	133 – 157	25	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8MH63 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 60A302239800C3F8	FASTA	180	18,779
	10 20 30 40 50 60 MAGAGPKRRA LAAPVAEEKE EAREKMLASK RADGAAPAGE GEGVTLQRNI TLLNGVAIIV 70 80 90 100 110 120 GAIIGSGIFV TPTGVLKEAG SPGLALVMWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 130 140 150 160 170 180 LDVYGSLPAF LKLWIELLVI RPSSQYIVAL VFATYLLKPL FPSCPVPEEA AKLMACHCVH

References

[1]

"Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1." Ito M., Takebayashi S., Okumura K., Ohkubo T., Nishio M., Kawano M., Komada H., Ito Y., Tsurudome M. Int. J. Biochem. Cell Biol. 34:1152-1163(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB055226 mRNA. Translation: BAB97212.1.
IPI	IPI00896392.
3D structure databases
ProteinModelPortal	Q8MH63.
SMR	Q8MH63. Positions 47-160.
ModBase	Search...
Polymorphism databases
DMDM	74750867.
Proteomic databases
PaxDb	Q8MH63.
PRIDE	Q8MH63.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc002dtl.1. human.
Organism-specific databases
GeneCards	GC16M029627.
HGNC	HGNC:29458. SLC7A5P1.
neXtProt	NX_Q8MH63.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0531.
HOVERGEN	HBG061804.
InParanoid	Q8MH63.
OrthoDB	EOG4J1186.
Gene expression databases
Genevestigator	Q8MH63.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit.
ProtoNet	Search...
Other
NextBio	35541139.

Entry information

Entry name

LAT1N_HUMAN

Accession

Primary (citable) accession number: Q8MH63

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.