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Q8MH63

- LAT1N_HUMAN

UniProt

Q8MH63 - LAT1N_HUMAN

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Protein

Putative L-type amino acid transporter 1-like protein MLAS

Gene

SLC7A5P1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-type amino acid transporter 1-like protein MLAS
Alternative name(s):
hLAT1 3-transmembrane protein MLAS
Short name:
hLAT1 3TM MLAS
Gene namesi
Name:SLC7A5P1
Synonyms:MLAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:29458. SLC7A5P1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15725HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Putative L-type amino acid transporter 1-like protein MLASPRO_0000348251Add
BLAST

Proteomic databases

MaxQBiQ8MH63.
PaxDbiQ8MH63.
PRIDEiQ8MH63.

Expressioni

Tissue specificityi

Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines.1 Publication

Gene expression databases

GenevestigatoriQ8MH63.

Structurei

3D structure databases

ProteinModelPortaliQ8MH63.
SMRiQ8MH63. Positions 47-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOVERGENiHBG061804.
InParanoidiQ8MH63.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8MH63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAGPKRRA LAAPVAEEKE EAREKMLASK RADGAAPAGE GEGVTLQRNI
60 70 80 90 100
TLLNGVAIIV GAIIGSGIFV TPTGVLKEAG SPGLALVMWA ACGVFSIVGA
110 120 130 140 150
LCYAELGTTI SKSGGDYAYM LDVYGSLPAF LKLWIELLVI RPSSQYIVAL
160 170 180
VFATYLLKPL FPSCPVPEEA AKLMACHCVH
Length:180
Mass (Da):18,779
Last modified:October 1, 2002 - v1
Checksum:i60A302239800C3F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055226 mRNA. Translation: BAB97212.1.

Genome annotation databases

UCSCiuc002dtl.1. human.

Polymorphism databases

DMDMi74750867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055226 mRNA. Translation: BAB97212.1 .

3D structure databases

ProteinModelPortali Q8MH63.
SMRi Q8MH63. Positions 47-160.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74750867.

Proteomic databases

MaxQBi Q8MH63.
PaxDbi Q8MH63.
PRIDEi Q8MH63.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002dtl.1. human.

Organism-specific databases

GeneCardsi GC16M029627.
HGNCi HGNC:29458. SLC7A5P1.
neXtProti NX_Q8MH63.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0531.
HOVERGENi HBG061804.
InParanoidi Q8MH63.

Miscellaneous databases

NextBioi 35541139.

Gene expression databases

Genevestigatori Q8MH63.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1."
    Ito M., Takebayashi S., Okumura K., Ohkubo T., Nishio M., Kawano M., Komada H., Ito Y., Tsurudome M.
    Int. J. Biochem. Cell Biol. 34:1152-1163(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAT1N_HUMAN
AccessioniPrimary (citable) accession number: Q8MH63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3