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Q8MH63

- LAT1N_HUMAN

UniProt

Q8MH63 - LAT1N_HUMAN

Protein

Putative L-type amino acid transporter 1-like protein MLAS

Gene

SLC7A5P1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative L-type amino acid transporter 1-like protein MLAS
    Alternative name(s):
    hLAT1 3-transmembrane protein MLAS
    Short name:
    hLAT1 3TM MLAS
    Gene namesi
    Name:SLC7A5P1
    Synonyms:MLAS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:29458. SLC7A5P1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Putative L-type amino acid transporter 1-like protein MLASPRO_0000348251Add
    BLAST

    Proteomic databases

    MaxQBiQ8MH63.
    PaxDbiQ8MH63.
    PRIDEiQ8MH63.

    Expressioni

    Tissue specificityi

    Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines.1 Publication

    Gene expression databases

    GenevestigatoriQ8MH63.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8MH63.
    SMRiQ8MH63. Positions 47-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15725HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOVERGENiHBG061804.
    InParanoidiQ8MH63.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8MH63-1 [UniParc]FASTAAdd to Basket

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    MAGAGPKRRA LAAPVAEEKE EAREKMLASK RADGAAPAGE GEGVTLQRNI    50
    TLLNGVAIIV GAIIGSGIFV TPTGVLKEAG SPGLALVMWA ACGVFSIVGA 100
    LCYAELGTTI SKSGGDYAYM LDVYGSLPAF LKLWIELLVI RPSSQYIVAL 150
    VFATYLLKPL FPSCPVPEEA AKLMACHCVH 180
    Length:180
    Mass (Da):18,779
    Last modified:October 1, 2002 - v1
    Checksum:i60A302239800C3F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055226 mRNA. Translation: BAB97212.1.

    Genome annotation databases

    UCSCiuc002dtl.1. human.

    Polymorphism databases

    DMDMi74750867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055226 mRNA. Translation: BAB97212.1 .

    3D structure databases

    ProteinModelPortali Q8MH63.
    SMRi Q8MH63. Positions 47-160.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74750867.

    Proteomic databases

    MaxQBi Q8MH63.
    PaxDbi Q8MH63.
    PRIDEi Q8MH63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc002dtl.1. human.

    Organism-specific databases

    GeneCardsi GC16M029627.
    HGNCi HGNC:29458. SLC7A5P1.
    neXtProti NX_Q8MH63.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOVERGENi HBG061804.
    InParanoidi Q8MH63.

    Miscellaneous databases

    NextBioi 35541139.

    Gene expression databases

    Genevestigatori Q8MH63.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1."
      Ito M., Takebayashi S., Okumura K., Ohkubo T., Nishio M., Kawano M., Komada H., Ito Y., Tsurudome M.
      Int. J. Biochem. Cell Biol. 34:1152-1163(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAT1N_HUMAN
    AccessioniPrimary (citable) accession number: Q8MH63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3