Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8MH63 (LAT1N_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative L-type amino acid transporter 1-like protein MLAS
Alternative name(s):
hLAT1 3-transmembrane protein MLAS
Short name=hLAT1 3TM MLAS
Gene names
Name:SLC7A5P1
Synonyms:MLAS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionamino acid transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Putative L-type amino acid transporter 1-like protein MLAS
PRO_0000348251

Regions

Transmembrane56 – 7621Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane133 – 15725Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8MH63 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 60A302239800C3F8

FASTA18018,779
        10         20         30         40         50         60 
MAGAGPKRRA LAAPVAEEKE EAREKMLASK RADGAAPAGE GEGVTLQRNI TLLNGVAIIV 

        70         80         90        100        110        120 
GAIIGSGIFV TPTGVLKEAG SPGLALVMWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 

       130        140        150        160        170        180 
LDVYGSLPAF LKLWIELLVI RPSSQYIVAL VFATYLLKPL FPSCPVPEEA AKLMACHCVH 

« Hide

References

[1]"Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1."
Ito M., Takebayashi S., Okumura K., Ohkubo T., Nishio M., Kawano M., Komada H., Ito Y., Tsurudome M.
Int. J. Biochem. Cell Biol. 34:1152-1163(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB055226 mRNA. Translation: BAB97212.1.

3D structure databases

ProteinModelPortalQ8MH63.
SMRQ8MH63. Positions 47-160.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74750867.

Proteomic databases

PaxDbQ8MH63.
PRIDEQ8MH63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc002dtl.1. human.

Organism-specific databases

GeneCardsGC16M029627.
HGNCHGNC:29458. SLC7A5P1.
neXtProtNX_Q8MH63.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0531.
HOVERGENHBG061804.
InParanoidQ8MH63.

Gene expression databases

GenevestigatorQ8MH63.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35541139.

Entry information

Entry nameLAT1N_HUMAN
AccessionPrimary (citable) accession number: Q8MH63
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM