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Q8LW54

- MEL_APICE

UniProt

Q8LW54 - MEL_APICE

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Protein

Melittin

Gene
MELT
Organism
Apis cerana (Indian honeybee)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange By similarity.

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Melittin
Gene namesi
Name:MELT
OrganismiApis cerana (Indian honeybee)
Taxonomic identifieri7461 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Secreted. Target cell membrane By similarity
Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey By similarity.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. other organism cell membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Propeptidei31 – 5020Removed by a dipeptidylpeptidase By similarityPRO_0000035146Add
BLAST
Peptidei51 – 7626Melittin1 PublicationPRO_0000035147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761Glutamine amide1 Publication

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer and homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8LW54.
SMRiQ8LW54. Positions 51-76.

Family & Domainsi

Sequence similaritiesi

Belongs to the melittin family.

Keywords - Domaini

Signal, Transmembrane

Family and domain databases

InterProiIPR002116. Melittin/Api_allergen.
[Graphical view]
PfamiPF01372. Melittin. 1 hit.
[Graphical view]
ProDomiPD014636. Melittin/Api_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LW54-1 [UniParc]FASTAAdd to Basket

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MKFLVNVALV FYGRVHFLHL CVHFLHLWAP EPEPAPEAEA EADAEADPEA   50
GIGAVLKVLT TGLPALISWI KRKRQQG 77
Length:77
Mass (Da):8,515
Last modified:October 1, 2002 - v1
Checksum:i091BEF7CE6019374
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489619 Genomic DNA. Translation: CAD33921.1.
PIRiA01762. MEHBCI.

Cross-referencesi

Web resourcesi

Protein Spotlight

Why Pooh luvvs hunny - Issue 12 of July 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489619 Genomic DNA. Translation: CAD33921.1 .
PIRi A01762. MEHBCI.

3D structure databases

ProteinModelPortali Q8LW54.
SMRi Q8LW54. Positions 51-76.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002116. Melittin/Api_allergen.
[Graphical view ]
Pfami PF01372. Melittin. 1 hit.
[Graphical view ]
ProDomi PD014636. Melittin/Api_allergen. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Gene encoding melittin in honeybee Apis cerana colleted in Hanoi Vietnam."
    Le H.Q., Le B.T.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of melittin isolated from two species of honey bees."
    Kreil G.
    FEBS Lett. 33:241-244(1973)
    Cited for: PROTEIN SEQUENCE OF 51-76, AMIDATION AT GLN-76.

Entry informationi

Entry nameiMEL_APICE
AccessioniPrimary (citable) accession number: Q8LW54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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