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Protein

Transcription initiation factor TFIID subunit 1

Gene

TAF1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Core scaffold of the TFIID complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA mediated transformation Source: TAIR
  • positive regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-674695 RNA Polymerase II Pre-transcription Events
R-ATH-73776 RNA Polymerase II Promoter Escape
R-ATH-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-ATH-75953 RNA Polymerase II Transcription Initiation
R-ATH-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1
Alternative name(s):
TAFII250-A
TBP-associated factor 1
Short name:
AtTAF1
Transcription initiation factor TFIID subunit 1-A
Gene namesi
Name:TAF1
Synonyms:GTD1, HAC13, HAF1, TAF1A
Ordered Locus Names:At1g32750
ORF Names:F6N18.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G32750
TAIRilocus:2035574 AT1G32750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697531 – 1919Transcription initiation factor TFIID subunit 1Add BLAST1919

Proteomic databases

PaxDbiQ8LRK9
PRIDEiQ8LRK9

PTM databases

iPTMnetiQ8LRK9

Expressioni

Tissue specificityi

Expressed in roots, leaves and inflorescences.1 Publication

Gene expression databases

ExpressionAtlasiQ8LRK9 baseline and differential
GenevisibleiQ8LRK9 AT

Interactioni

Subunit structurei

Component of the TFIID complex. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 14-217 kDa. Interacts with TAF7 and TAF14B, and (via N-terminus) with TBP1 and TBP2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi25403, 10 interactors
IntActiQ8LRK9, 10 interactors
STRINGi3702.AT1G32750.1

Structurei

3D structure databases

ProteinModelPortaliQ8LRK9
SMRiQ8LRK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini661 – 737Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77
Domaini1816 – 1886BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1713 – 1750Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 106Asp-richAdd BLAST91
Compositional biasi145 – 210Glu-richAdd BLAST66
Compositional biasi1289 – 1296Poly-Lys8
Compositional biasi1670 – 1733Glu-richAdd BLAST64

Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
HOGENOMiHOG000030311
InParanoidiQ8LRK9
KOiK03125
OMAiEHRSSEH
OrthoDBiEOG093600AG
PhylomeDBiQ8LRK9

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF00240 ubiquitin, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LRK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESNGKGSH NETSSDDDDE YEDNSRGFNL GFIFGNVDNS GDLDADYLDE
60 70 80 90 100
DAKEHLSALA DKLGSSLPDI NLLAKSERTA SDPAEQDYDR KAEDAVDYED
110 120 130 140 150
IDEEYDGPEV QVVSEEDHLL PKKEYFSTAV ALGSLKSRAS VFDDEDYDEE
160 170 180 190 200
EEQEEEQAPV EKSLETEKRE PVVLKEDKAL EYEEEASILD KEDHMDTEDV
210 220 230 240 250
QEEEVDELLE GTLDDKGATP LPTLYVEDGM VILQFSEIFA IHEPPQKRDR
260 270 280 290 300
RENRYVTCRD KYKSMDISEL VEDDEEVLLK SHGRIDTHVE QADLIQLDVP
310 320 330 340 350
FPIREGLQLV KASTIGGITP ESREFTKLGR DSCIMGELLK QDFIDDNSSL
360 370 380 390 400
CQSQLSMQVF PLDQHEWERR IIWEHSPEIS GNSGEIFEPG LEPEGMLVKG
410 420 430 440 450
TNSETEQESL NVVNSRVQVQ ADNNMFVPFS ANLLESFGSR GSQSTNESTN
460 470 480 490 500
KSRHHPQLLR LESQWDENHL SGNDEAGVKK IKRLEKDALG RFSRLVLRER
510 520 530 540 550
DLGDEAWLDS IIWDSEKELS RSKLIFDLQD EQMVFEIFDN EESKNLQLHA
560 570 580 590 600
GAMIVSRSSK SKDETFQEGC ESNSGWQFNL SNDKFYMNGK SSQQLQANTN
610 620 630 640 650
KSSVHSLRVF HSVPAIKLQT MKSKLSNKDI ANFHRPKALW YPHDNELAIK
660 670 680 690 700
QQGKLPTRGS MKIIVKSLGG KGSKLHVGIE ESVSSLRAKA SRKLDFKETE
710 720 730 740 750
AVKMFYKGKE LDDEKSLAAQ NVQPNSLVHL IRTKVHLWPW AQKLPGENKS
760 770 780 790 800
LRPPGAFKKK SDLSTKDGHV FLMEYCEERP LMLSNAGMGA NLCTYYQKSS
810 820 830 840 850
PEDQRGNLLR NQSDTLGNVM ILEPGDKSPF LGEIHAGCSQ SSVETNMYKA
860 870 880 890 900
PIFPQRLQST DYLLVRSPKG KLSLRRIDKI VVVGQQEPRM EVMSPGSKNL
910 920 930 940 950
QTYLVNRMLV YVYREFFKRG GGEHPIAADE LSFLFSNLTD AIIKKNMKII
960 970 980 990 1000
ACWKRDKNGQ SYWTKKDSLL EPPESELKKL VAPEHVCSYE SMLAGLYRLK
1010 1020 1030 1040 1050
HLGITRFTLP ASISNALAQL PDEAIALAAA SHIERELQIT PWNLSSNFVA
1060 1070 1080 1090 1100
CTNQDRANIE RLEITGVGDP SGRGLGFSYV RAAPKAPAAA GHMKKKAAAG
1110 1120 1130 1140 1150
RGAPTVTGTD ADLRRLSMEA AREVLIKFNV PDEIIAKQTR WHRIAMIRKL
1160 1170 1180 1190 1200
SSEQAASGVK VDPTTIGKYA RGQRMSFLQM QQQAREKCQE IWDRQLLSLS
1210 1220 1230 1240 1250
AFDGDENESE NEANSDLDSF AGDLENLLDA EEGGEGEESN ISKNDKLDGV
1260 1270 1280 1290 1300
KGLKMRRRPS QVETDEEIED EATEYAELCR LLMQDEDQKK KKKKMKGVGE
1310 1320 1330 1340 1350
GMGSYPPPRP NIALQSGEPV RKANAMDKKP IAIQPDASFL VNESTIKDNR
1360 1370 1380 1390 1400
NVDSIIKTPK GKQVKENSNS LGQLKKVKIL NENLKVFKEK KSARENFVCG
1410 1420 1430 1440 1450
ACGQHGHMRT NKHCPRYREN TESQPEGIDM DKSAGKPSSS EPSGLPKLKP
1460 1470 1480 1490 1500
IKNSKAAPKS AMKTSVDEAL KGDKLSSKTG GLPLKFRYGI PAGDLSDKPV
1510 1520 1530 1540 1550
SEAPGSSEQA VVSDIDTGIK STSKISKLKI SSKAKPKESK GESERRSHSL
1560 1570 1580 1590 1600
MPTFSRERGE SESHKPSVSG QPLSSTERNQ AASSRHTISI PRPSLSMDTD
1610 1620 1630 1640 1650
QAESRRPHLV IRPPTEREQP QKKLVIKRSK EMNDHDMSSL EESPRFESRK
1660 1670 1680 1690 1700
TKRMAELAGF QRQQSFRLSE NSLERRPKED RVWWEEEEIS TGRHREVRAR
1710 1720 1730 1740 1750
RDYDDMSVSE EPNEIAEIRR YEEVIRSERE EEERQKAKKK KKKKKLQPEI
1760 1770 1780 1790 1800
VEGYLEDYPP RKNDRRLSER GRNVRSRYVS DFERDGAEYA PQPKRRKKGE
1810 1820 1830 1840 1850
VGLANILERI VDTLRLKEEV SRLFLKPVSK KEAPDYLDIV ENPMDLSTIR
1860 1870 1880 1890 1900
DKVRKIEYRN REQFRHDVWQ IKYNAHLYND GRNPGIPPLA DQLLEICDYL
1910
LDDYEDQLKE AEKGIDPND
Length:1,919
Mass (Da):217,194
Last modified:October 1, 2002 - v1
Checksum:iEDB5443616D371BF
GO

Sequence cautioni

The sequence AAF25977 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510669 mRNA Translation: AAM34782.1
AC017118 Genomic DNA Translation: AAF25977.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31524.1
PIRiD86452
RefSeqiNP_174552.1, NM_103009.4
UniGeneiAt.40077
At.48257

Genome annotation databases

EnsemblPlantsiAT1G32750.1; AT1G32750.1; AT1G32750
GeneIDi840169
GrameneiAT1G32750.1; AT1G32750.1; AT1G32750
KEGGiath:AT1G32750

Similar proteinsi

Entry informationi

Entry nameiTAF1_ARATH
AccessioniPrimary (citable) accession number: Q8LRK9
Secondary accession number(s): Q9LPI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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