ID   HDA18_ARATH             Reviewed;         682 AA.
AC   Q8LRK8; Q9FNQ7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Histone deacetylase 18;
DE            EC=3.5.1.98;
GN   Name=HDA18; OrderedLocusNames=At5g61070; ORFNames=MAF19.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   MEDLINE=22354691; PubMed=12466527; DOI=10.1093/nar/gkf660;
RA   Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S.,
RA   Richards E.J., Bender J., Mount D.W., Jorgensen R.A.;
RT   "Analysis of histone acetyltransferase and histone deacetylase
RT   families of Arabidopsis thaliana suggests functional diversification
RT   of chromatin modification among multicellular eukaryotes.";
RL   Nucleic Acids Res. 30:5036-5055(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=98069011; PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA   Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. II.
RT   Sequence features of the regions of 1,044,062 bp covered by thirteen
RT   physically assigned P1 clones.";
RL   DNA Res. 4:291-300(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=16176989; DOI=10.1073/pnas.0503143102;
RA   Xu C.-R., Liu C., Wang Y.-L., Li L.-C., Chen W.-Q., Xu Z.-H.,
RA   Bai S.-N.;
RT   "Histone acetylation affects expression of cellular patterning genes
RT   in the Arabidopsis root epidermis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:14469-14474(2005).
CC   -!- FUNCTION: Responsible for the deacetylation of lysine residues on
CC       the N-terminal part of the core histones (H2A, H2B, H3 and H4).
CC       Histone deacetylation gives a tag for epigenetic repression and
CC       plays an important role in transcriptional regulation, cell cycle
CC       progression and developmental events. Required for appropriate
CC       cellular patterning in the root epidermis. Histone deacetylases
CC       act via the formation of large multiprotein complexes (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- MISCELLANEOUS: HDA5, a tandem duplication of HDA18, is not
CC       required for the cellular patterning in the root epidermis.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. Type 2
CC       subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10370.1; Type=Erroneous gene model prediction;
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DR   EMBL; AF510670; AAM34783.1; -; mRNA.
DR   EMBL; AB006696; BAB10370.1; ALT_SEQ; Genomic_DNA.
DR   IPI; IPI00530796; -.
DR   RefSeq; NP_200915.2; -.
DR   UniGene; At.29127; -.
DR   GeneID; 836228; -.
DR   GenomeReviews; BA000015_GR; AT5G61070.
DR   KEGG; ath:AT5G61070; -.
DR   NMPDR; fig|3702.1.peg.28125; -.
DR   TAIR; At5g61070; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0045604; P:regulation of epidermal cell differentiation; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000286; His_deacetylse.
DR   Gene3D; G3DSA:3.40.800.20; His_deacetylse; 1.
DR   PANTHER; PTHR10625; His_deacetylse; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Coiled coil; Complete proteome; Hydrolase;
KW   Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    682       Histone deacetylase 18.
FT                                /FTId=PRO_0000280093.
FT   REGION       59    382       Histone deacetylase.
FT   COILED      430    608       Potential.
FT   ACT_SITE    191    191       By similarity.
SQ   SEQUENCE   682 AA;  76634 MW;  67D91533AB998840 CRC64;
     MLLKFEASSE LRLVDPSVSL TVLRKIRLSH LPDMTMTSES SGKKCGEGDG KVAGKSQRKV
     GLVYDETMCK HDTPNGKVDV ECPDRIRVIW EKLQLAGVTQ RCVVLGGSKA EDKHLKLVHT
     KKHVNLVKSI STKKKDSRRN KIASQLDSIY LNGGSSEAAY LAAGSVVKVA EKVAEGELDC
     GFAIVRPPGH HAESDEAMGF CLFNNVAVAA SFLLNERPDL DVKKILIVDW DIHHGNGTQK
     MFWKDSRVLI FSVHRHDHGS FYPFGDDGDF NMVGEGPGEG FNINVPWEQG GCGDADYLAV
     WNHILIPVTK EFKPDIILLS AGFDAAIGDP LGGCCVTPYG YSVMLKKLME FAHGKIVLAL
     EGGYNLESLG KSSLACVQVL LEDKQIHGSS ETYPLESTRR VIQAVRERLC TYWPSLDASM
     ASNENLKNPS AERNSADALL REVEELKSLM AARDGELEAR RKELKAKNKE LEANEKELEA
     GLMLIRARED VICGLHAKIE SLQQERDEAV AKAERIDKEL QEDRARSQEF KEDTEFCLST
     LRREKELAIM AKNKDLEAKE KELEARLMLV HAREDKIHAK IERLQQERDE AVAKAERIDK
     ELQEDRSRSR VGNGSFAFSQ EFYEDMDLDE LEPLSPEFNE DMDSEELEPF QVIKKNMERS
     HKKFIKDMEC IKFIASERAR VL
//