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Q8LRK8

- HDA18_ARATH

UniProt

Q8LRK8 - HDA18_ARATH

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Protein
Histone deacetylase 18
Gene
HDA18, At5g61070, MAF19.8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes By similarity.1 Publication

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. histone deacetylase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. chromatin remodeling Source: TAIR
  2. histone deacetylation Source: GOC
  3. regulation of epidermal cell differentiation Source: TAIR
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. root epidermal cell differentiation Source: TAIR
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciARA:AT5G61070-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 18 (EC:3.5.1.98)
Gene namesi
Name:HDA18
Ordered Locus Names:At5g61070
ORF Names:MAF19.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G61070.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Histone deacetylase 18
PRO_0000280093Add
BLAST

Proteomic databases

PRIDEiQ8LRK8.

Expressioni

Gene expression databases

GenevestigatoriQ8LRK8.

Interactioni

Protein-protein interaction databases

BioGridi21472. 1 interaction.
STRINGi3702.AT5G61070.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8LRK8.
SMRiQ8LRK8. Positions 61-413.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 382324Histone deacetylase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili430 – 608179 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiQ8LRK8.
KOiK11407.
OMAiLVYDETM.
PhylomeDBiQ8LRK8.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q8LRK8-1 [UniParc]FASTAAdd to Basket

« Hide

MLLKFEASSE LRLVDPSVSL TVLRKIRLSH LPDMTMTSES SGKKCGEGDG    50
KVAGKSQRKV GLVYDETMCK HDTPNGKVDV ECPDRIRVIW EKLQLAGVTQ 100
RCVVLGGSKA EDKHLKLVHT KKHVNLVKSI STKKKDSRRN KIASQLDSIY 150
LNGGSSEAAY LAAGSVVKVA EKVAEGELDC GFAIVRPPGH HAESDEAMGF 200
CLFNNVAVAA SFLLNERPDL DVKKILIVDW DIHHGNGTQK MFWKDSRVLI 250
FSVHRHDHGS FYPFGDDGDF NMVGEGPGEG FNINVPWEQG GCGDADYLAV 300
WNHILIPVTK EFKPDIILLS AGFDAAIGDP LGGCCVTPYG YSVMLKKLME 350
FAHGKIVLAL EGGYNLESLG KSSLACVQVL LEDKQIHGSS ETYPLESTRR 400
VIQAVRERLC TYWPSLDASM ASNENLKNPS AERNSADALL REVEELKSLM 450
AARDGELEAR RKELKAKNKE LEANEKELEA GLMLIRARED VICGLHAKIE 500
SLQQERDEAV AKAERIDKEL QEDRARSQEF KEDTEFCLST LRREKELAIM 550
AKNKDLEAKE KELEARLMLV HAREDKIHAK IERLQQERDE AVAKAERIDK 600
ELQEDRSRSR VGNGSFAFSQ EFYEDMDLDE LEPLSPEFNE DMDSEELEPF 650
QVIKKNMERS HKKFIKDMEC IKFIASERAR VL 682
Length:682
Mass (Da):76,634
Last modified:October 1, 2002 - v1
Checksum:i67D91533AB998840
GO

Sequence cautioni

The sequence BAB10370.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510670 mRNA. Translation: AAM34783.1.
AB006696 Genomic DNA. Translation: BAB10370.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED97419.1.
RefSeqiNP_200915.2. NM_125500.2.
UniGeneiAt.29127.

Genome annotation databases

EnsemblPlantsiAT5G61070.1; AT5G61070.1; AT5G61070.
GeneIDi836228.
KEGGiath:AT5G61070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510670 mRNA. Translation: AAM34783.1 .
AB006696 Genomic DNA. Translation: BAB10370.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED97419.1 .
RefSeqi NP_200915.2. NM_125500.2.
UniGenei At.29127.

3D structure databases

ProteinModelPortali Q8LRK8.
SMRi Q8LRK8. Positions 61-413.
ModBasei Search...

Protein-protein interaction databases

BioGridi 21472. 1 interaction.
STRINGi 3702.AT5G61070.1-P.

Proteomic databases

PRIDEi Q8LRK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G61070.1 ; AT5G61070.1 ; AT5G61070 .
GeneIDi 836228.
KEGGi ath:AT5G61070.

Organism-specific databases

TAIRi AT5G61070.

Phylogenomic databases

eggNOGi COG0123.
InParanoidi Q8LRK8.
KOi K11407.
OMAi LVYDETM.
PhylomeDBi Q8LRK8.

Enzyme and pathway databases

BioCyci ARA:AT5G61070-MONOMER.

Gene expression databases

Genevestigatori Q8LRK8.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence features of the regions of 1,044,062 bp covered by thirteen physically assigned P1 clones."
    Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 4:291-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis."
    Xu C.-R., Liu C., Wang Y.-L., Li L.-C., Chen W.-Q., Xu Z.-H., Bai S.-N.
    Proc. Natl. Acad. Sci. U.S.A. 102:14469-14474(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHDA18_ARATH
AccessioniPrimary (citable) accession number: Q8LRK8
Secondary accession number(s): Q9FNQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

HDA5, a tandem duplication of HDA18, is not required for the cellular patterning in the root epidermis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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