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Q8LQ68

- HXK6_ORYSJ

UniProt

Q8LQ68 - HXK6_ORYSJ

Protein

Hexokinase-6

Gene

HXK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol By similarity.By similarity

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 1146ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-6 (EC:2.7.1.1)
    Alternative name(s):
    Hexokinase-2
    Gene namesi
    Name:HXK6
    Synonyms:HXK2
    Ordered Locus Names:Os01g0742500, LOC_Os01g53930
    ORF Names:P0439E07.19
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ8LQ68.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast outer membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chloroplast, Membrane, Plastid, Plastid outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Hexokinase-6PRO_0000247569Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in roots, leaves, flowers, immature seeds and endosperm.1 Publication

    Developmental stagei

    Expressed during flower development until 15 days after flowering.1 Publication

    Inductioni

    By glucose or fructose treatment in leaves.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os01g53930.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LQ68.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 248201Hexokinase type-1Add
    BLAST
    Domaini257 – 498242Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni179 – 20527Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    KOiK00844.
    OMAiMSTIVAD.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8LQ68-1 [UniParc]FASTAAdd to Basket

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    MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE    50
    EVEQRFSTPT ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD 100
    EHGLFYALDL GGTNFRVIRV QLGGREKRVV SQQYEEVAIP PHLMVGTSME 150
    LFDFIAAELE SFVKTEGEDF HLPEGRQREL GFTFSFPVHQ TSISSGTLIK 200
    WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV GTLAGGRYVD 250
    NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER 300
    LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG 350
    DVVPTKLEQR FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR 400
    YITLHVCDLV AERGARLAAA GIYGILKKLG RDRVPSDGSQ KQRTVIALDG 450
    GLYEHYKKFR TCLEATLADL LGEEAASSVV VKLANDGSGI GAALLAASHS 500
    QYASVE 506
    Length:506
    Mass (Da):55,121
    Last modified:October 1, 2002 - v1
    Checksum:i242F8DCCB5FF8947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116388 mRNA. Translation: AAZ93623.1.
    AY884165 mRNA. Translation: AAX68418.1.
    AP003768 Genomic DNA. Translation: BAB91930.1.
    RefSeqiNP_001044214.1. NM_001050749.1.
    UniGeneiOs.5547.

    Genome annotation databases

    EnsemblPlantsiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
    GeneIDi4326547.
    KEGGiosa:4326547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116388 mRNA. Translation: AAZ93623.1 .
    AY884165 mRNA. Translation: AAX68418.1 .
    AP003768 Genomic DNA. Translation: BAB91930.1 .
    RefSeqi NP_001044214.1. NM_001050749.1.
    UniGenei Os.5547.

    3D structure databases

    ProteinModelPortali Q8LQ68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os01g53930.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0742500-01 ; OS01T0742500-01 ; OS01G0742500 .
    GeneIDi 4326547.
    KEGGi osa:4326547.

    Organism-specific databases

    Gramenei Q8LQ68.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    KOi K00844.
    OMAi MSTIVAD.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
      Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
      Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
      Strain: cv. Jinmi.
    2. "The hexokinase gene family in rice."
      Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Zhonghua 15.
      Tissue: Flower.
    3. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHXK6_ORYSJ
    AccessioniPrimary (citable) accession number: Q8LQ68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3