Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8LQ68

- HXK6_ORYSJ

UniProt

Q8LQ68 - HXK6_ORYSJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hexokinase-6

Gene

HXK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1146ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_252558. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_255428. Regulation of gene expression in beta cells.
REACT_261692. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-6 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-2
Gene namesi
Name:HXK6
Synonyms:HXK2
Ordered Locus Names:Os01g0742500, LOC_Os01g53930
ORF Names:P0439E07.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ8LQ68.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plastid outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Plastid outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Hexokinase-6PRO_0000247569Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds and endosperm.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LQ68. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g53930.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LQ68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 248201Hexokinase type-1Add
BLAST
Domaini257 – 498242Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 20527Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ8LQ68.
KOiK00844.
OMAiMSTIVAD.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LQ68-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE
60 70 80 90 100
EVEQRFSTPT ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD
110 120 130 140 150
EHGLFYALDL GGTNFRVIRV QLGGREKRVV SQQYEEVAIP PHLMVGTSME
160 170 180 190 200
LFDFIAAELE SFVKTEGEDF HLPEGRQREL GFTFSFPVHQ TSISSGTLIK
210 220 230 240 250
WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV GTLAGGRYVD
260 270 280 290 300
NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER
310 320 330 340 350
LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG
360 370 380 390 400
DVVPTKLEQR FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR
410 420 430 440 450
YITLHVCDLV AERGARLAAA GIYGILKKLG RDRVPSDGSQ KQRTVIALDG
460 470 480 490 500
GLYEHYKKFR TCLEATLADL LGEEAASSVV VKLANDGSGI GAALLAASHS

QYASVE
Length:506
Mass (Da):55,121
Last modified:October 1, 2002 - v1
Checksum:i242F8DCCB5FF8947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA. Translation: AAZ93623.1.
AY884165 mRNA. Translation: AAX68418.1.
AP003768 Genomic DNA. Translation: BAB91930.1.
RefSeqiNP_001044214.1. NM_001050749.1.
UniGeneiOs.5547.

Genome annotation databases

EnsemblPlantsiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
GeneIDi4326547.
KEGGiosa:4326547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA. Translation: AAZ93623.1 .
AY884165 mRNA. Translation: AAX68418.1 .
AP003768 Genomic DNA. Translation: BAB91930.1 .
RefSeqi NP_001044214.1. NM_001050749.1.
UniGenei Os.5547.

3D structure databases

ProteinModelPortali Q8LQ68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os01g53930.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0742500-01 ; OS01T0742500-01 ; OS01G0742500 .
GeneIDi 4326547.
KEGGi osa:4326547.

Organism-specific databases

Gramenei Q8LQ68.

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162670.
InParanoidi Q8LQ68.
KOi K00844.
OMAi MSTIVAD.

Enzyme and pathway databases

Reactomei REACT_252558. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_255428. Regulation of gene expression in beta cells.
REACT_261692. Glucose transport.

Gene expression databases

ExpressionAtlasi Q8LQ68. baseline.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
    Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
    Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
    Strain: cv. Jinmi.
  2. "The hexokinase gene family in rice."
    Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Zhonghua 15.
    Tissue: Flower.
  3. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHXK6_ORYSJ
AccessioniPrimary (citable) accession number: Q8LQ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3