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Q8LQ68 (HXK6_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-6

EC=2.7.1.1
Alternative name(s):
Hexokinase-2
Gene names
Name:HXK6
Synonyms:HXK2
Ordered Locus Names:Os01g0742500, LOC_Os01g53930
ORF Names:P0439E07.19
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol By similarity. Ref.1

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Subcellular location

Plastidchloroplast outer membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed in roots, leaves, flowers, immature seeds and endosperm. Ref.1

Developmental stage

Expressed during flower development until 15 days after flowering. Ref.1

Induction

By glucose or fructose treatment in leaves. Ref.1

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentChloroplast
Membrane
Plastid
Plastid outer membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchloroplast outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Hexokinase-6
PRO_0000247569

Regions

Transmembrane6 – 2621Helical; Potential
Domain48 – 248201Hexokinase type-1
Domain257 – 498242Hexokinase type-2
Nucleotide binding109 – 1146ATP Potential
Region179 – 20527Glucose-binding Potential

Sequences

Sequence LengthMass (Da)Tools
Q8LQ68 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 242F8DCCB5FF8947

FASTA50655,121
        10         20         30         40         50         60 
MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE EVEQRFSTPT 

        70         80         90        100        110        120 
ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD EHGLFYALDL GGTNFRVIRV 

       130        140        150        160        170        180 
QLGGREKRVV SQQYEEVAIP PHLMVGTSME LFDFIAAELE SFVKTEGEDF HLPEGRQREL 

       190        200        210        220        230        240 
GFTFSFPVHQ TSISSGTLIK WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV 

       250        260        270        280        290        300 
GTLAGGRYVD NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER 

       310        320        330        340        350        360 
LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG DVVPTKLEQR 

       370        380        390        400        410        420 
FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR YITLHVCDLV AERGARLAAA 

       430        440        450        460        470        480 
GIYGILKKLG RDRVPSDGSQ KQRTVIALDG GLYEHYKKFR TCLEATLADL LGEEAASSVV 

       490        500 
VKLANDGSGI GAALLAASHS QYASVE 

« Hide

References

« Hide 'large scale' references
[1]"Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
Strain: cv. Jinmi.
[2]"The hexokinase gene family in rice."
Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Zhonghua 15.
Tissue: Flower.
[3]"The genome sequence and structure of rice chromosome 1."
Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. expand/collapse author list , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ116388 mRNA. Translation: AAZ93623.1.
AY884165 mRNA. Translation: AAX68418.1.
AP003768 Genomic DNA. Translation: BAB91930.1.
RefSeqNP_001044214.1. NM_001050749.1.
UniGeneOs.5547.

3D structure databases

ProteinModelPortalQ8LQ68.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os01g53930.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS01T0742500-01; OS01T0742500-01; OS01G0742500.
GeneID4326547.
KEGGosa:4326547.

Organism-specific databases

GrameneQ8LQ68.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
KOK00844.
OMAMSTIVAD.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXK6_ORYSJ
AccessionPrimary (citable) accession number: Q8LQ68
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations