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Protein

Hexokinase-6

Gene

HXK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1146ATPSequence Analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glucokinase activity Source: CACAO

GO - Biological processi

  • glucose 6-phosphate metabolic process Source: GOC
  • glycolytic process Source: UniProtKB-KW
  • response to glucose Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.
ReactomeiREACT_302664. Glycolysis.
REACT_308647. Glucose transport.
REACT_333003. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_345429. Regulation of gene expression in beta cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-6 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-2
Gene namesi
Name:HXK6
Synonyms:HXK2
Ordered Locus Names:Os01g0742500, LOC_Os01g53930
ORF Names:P0439E07.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000000763 Componenti: Chromosome 1

Organism-specific databases

GrameneiQ8LQ68.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • chloroplast outer membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Plastid outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Hexokinase-6PRO_0000247569Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds and endosperm.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LQ68. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g53930.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LQ68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 497455HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 236139Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni179 – 20527Glucose-bindingSequence AnalysisAdd
BLAST
Regioni237 – 486250Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ8LQ68.
KOiK00844.
OMAiAKDTHAR.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE
60 70 80 90 100
EVEQRFSTPT ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD
110 120 130 140 150
EHGLFYALDL GGTNFRVIRV QLGGREKRVV SQQYEEVAIP PHLMVGTSME
160 170 180 190 200
LFDFIAAELE SFVKTEGEDF HLPEGRQREL GFTFSFPVHQ TSISSGTLIK
210 220 230 240 250
WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV GTLAGGRYVD
260 270 280 290 300
NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER
310 320 330 340 350
LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG
360 370 380 390 400
DVVPTKLEQR FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR
410 420 430 440 450
YITLHVCDLV AERGARLAAA GIYGILKKLG RDRVPSDGSQ KQRTVIALDG
460 470 480 490 500
GLYEHYKKFR TCLEATLADL LGEEAASSVV VKLANDGSGI GAALLAASHS

QYASVE
Length:506
Mass (Da):55,121
Last modified:October 1, 2002 - v1
Checksum:i242F8DCCB5FF8947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA. Translation: AAZ93623.1.
AY884165 mRNA. Translation: AAX68418.1.
AP003768 Genomic DNA. Translation: BAB91930.1.
RefSeqiNP_001044214.1. NM_001050749.1.
UniGeneiOs.5547.

Genome annotation databases

EnsemblPlantsiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
GeneIDi4326547.
KEGGiosa:4326547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA. Translation: AAZ93623.1.
AY884165 mRNA. Translation: AAX68418.1.
AP003768 Genomic DNA. Translation: BAB91930.1.
RefSeqiNP_001044214.1. NM_001050749.1.
UniGeneiOs.5547.

3D structure databases

ProteinModelPortaliQ8LQ68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os01g53930.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
GeneIDi4326547.
KEGGiosa:4326547.

Organism-specific databases

GrameneiQ8LQ68.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ8LQ68.
KOiK00844.
OMAiAKDTHAR.

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.
ReactomeiREACT_302664. Glycolysis.
REACT_308647. Glucose transport.
REACT_333003. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_345429. Regulation of gene expression in beta cells.

Gene expression databases

ExpressionAtlasiQ8LQ68. baseline.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
    Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
    Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
    Strain: cv. Jinmi.
  2. "The hexokinase gene family in rice."
    Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Zhonghua 15.
    Tissue: Flower.
  3. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHXK6_ORYSJ
AccessioniPrimary (citable) accession number: Q8LQ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.