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Protein

Hexokinase-6

Gene

HXK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol (By similarity).By similarity1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 114ATPSequence analysis6

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: GO_Central
  • glucokinase activity Source: CACAO
  • glucose binding Source: InterPro
  • mannokinase activity Source: GO_Central

GO - Biological processi

  • cellular glucose homeostasis Source: GO_Central
  • glycolytic process Source: GO_Central
  • response to glucose Source: CACAO

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.
ReactomeiR-OSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-6 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-2
Gene namesi
Name:HXK6
Synonyms:HXK2
Ordered Locus Names:Os01g0742500, LOC_Os01g53930
ORF Names:P0439E07.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Plastid outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475691 – 506Hexokinase-6Add BLAST506

Proteomic databases

PaxDbiQ8LQ68.

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds and endosperm.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Gene expression databases

GenevisibleiQ8LQ68. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g53930.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LQ68.
SMRiQ8LQ68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 497HexokinasePROSITE-ProRule annotationAdd BLAST455

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 236Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni179 – 205Glucose-bindingSequence analysisAdd BLAST27
Regioni237 – 486Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST250

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ8LQ68.
KOiK00844.
OMAiQEVKRYY.
OrthoDBiEOG093608SG.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8LQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE
60 70 80 90 100
EVEQRFSTPT ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD
110 120 130 140 150
EHGLFYALDL GGTNFRVIRV QLGGREKRVV SQQYEEVAIP PHLMVGTSME
160 170 180 190 200
LFDFIAAELE SFVKTEGEDF HLPEGRQREL GFTFSFPVHQ TSISSGTLIK
210 220 230 240 250
WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV GTLAGGRYVD
260 270 280 290 300
NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER
310 320 330 340 350
LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG
360 370 380 390 400
DVVPTKLEQR FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR
410 420 430 440 450
YITLHVCDLV AERGARLAAA GIYGILKKLG RDRVPSDGSQ KQRTVIALDG
460 470 480 490 500
GLYEHYKKFR TCLEATLADL LGEEAASSVV VKLANDGSGI GAALLAASHS

QYASVE
Length:506
Mass (Da):55,121
Last modified:October 1, 2002 - v1
Checksum:i242F8DCCB5FF8947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA. Translation: AAZ93623.1.
AY884165 mRNA. Translation: AAX68418.1.
AP003768 Genomic DNA. Translation: BAB91930.1.
AP008207 Genomic DNA. Translation: BAF06128.1.
AP014957 Genomic DNA. Translation: BAS74288.1.
AK065656 mRNA. Translation: BAG89607.1.
RefSeqiXP_015618116.1. XM_015762630.1.
UniGeneiOs.5547.

Genome annotation databases

EnsemblPlantsiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
GeneIDi4326547.
GrameneiOS01T0742500-01; OS01T0742500-01; OS01G0742500.
KEGGiosa:4326547.

Similar proteinsi

Entry informationi

Entry nameiHXK6_ORYSJ
AccessioniPrimary (citable) accession number: Q8LQ68
Secondary accession number(s): Q0JJF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families