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Protein

Hexokinase-6

Gene

HXK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol (By similarity).By similarity1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 114ATPSequence analysis6

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: GO_Central
  • glucokinase activity Source: CACAO
  • glucose binding Source: InterPro
  • mannokinase activity Source: GO_Central

GO - Biological processi

  • cellular glucose homeostasis Source: GO_Central
  • glycolytic process Source: GO_Central
  • response to glucose Source: CACAO

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1 4460
ReactomeiR-OSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-OSA-6798695 Neutrophil degranulation
R-OSA-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-6 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-2
Gene namesi
Name:HXK6
Synonyms:HXK2
Ordered Locus Names:Os01g0742500, LOC_Os01g53930
ORF Names:P0439E07.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Plastid outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475691 – 506Hexokinase-6Add BLAST506

Proteomic databases

PaxDbiQ8LQ68

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds and endosperm.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LQ68 baseline and differential
GenevisibleiQ8LQ68 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g53930.1

Structurei

3D structure databases

ProteinModelPortaliQ8LQ68
SMRiQ8LQ68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 497HexokinasePROSITE-ProRule annotationAdd BLAST455

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 236Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni179 – 205Glucose-bindingSequence analysisAdd BLAST27
Regioni237 – 486Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST250

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
HOGENOMiHOG000162670
InParanoidiQ8LQ68
KOiK00844
OMAiQEVKRYY
OrthoDBiEOG093608SG

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGTVVGTA VVVCAAAAAA VGVAVVVSRR RRSKREAEEE RRRRAAAVIE
60 70 80 90 100
EVEQRFSTPT ALLRGIADAM VEEMERGLRA DPHAPLKMLI SYVDNLPTGD
110 120 130 140 150
EHGLFYALDL GGTNFRVIRV QLGGREKRVV SQQYEEVAIP PHLMVGTSME
160 170 180 190 200
LFDFIAAELE SFVKTEGEDF HLPEGRQREL GFTFSFPVHQ TSISSGTLIK
210 220 230 240 250
WTKGFSINGT VGEDVVAELS RAMERQGLDM KVTALVNDTV GTLAGGRYVD
260 270 280 290 300
NDVAAAVILG TGTNAAYVEH ANAIPKWTGL LPRSGNMVIN MEWGNFKSER
310 320 330 340 350
LPRSDYDNAL DFESLNPGEQ IYEKMISGMY LGEIVRRILL KLAHDASLFG
360 370 380 390 400
DVVPTKLEQR FILRTPDMSA MHHDTSHDLK HLGAKLKDIL GVADTSLEAR
410 420 430 440 450
YITLHVCDLV AERGARLAAA GIYGILKKLG RDRVPSDGSQ KQRTVIALDG
460 470 480 490 500
GLYEHYKKFR TCLEATLADL LGEEAASSVV VKLANDGSGI GAALLAASHS

QYASVE
Length:506
Mass (Da):55,121
Last modified:October 1, 2002 - v1
Checksum:i242F8DCCB5FF8947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116388 mRNA Translation: AAZ93623.1
AY884165 mRNA Translation: AAX68418.1
AP003768 Genomic DNA Translation: BAB91930.1
AP008207 Genomic DNA Translation: BAF06128.1
AP014957 Genomic DNA Translation: BAS74288.1
AK065656 mRNA Translation: BAG89607.1
RefSeqiXP_015618116.1, XM_015762630.1
UniGeneiOs.5547

Genome annotation databases

EnsemblPlantsiOs01t0742500-01; Os01t0742500-01; Os01g0742500
GeneIDi4326547
GrameneiOs01t0742500-01; Os01t0742500-01; Os01g0742500
KEGGiosa:4326547

Similar proteinsi

Entry informationi

Entry nameiHXK6_ORYSJ
AccessioniPrimary (citable) accession number: Q8LQ68
Secondary accession number(s): Q0JJF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome