ID   ATX3_ORYSJ              Reviewed;         336 AA.
AC   Q8LQ36; Q0JHP3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 104.
DE   RecName: Full=Putative ataxin-3 homolog;
DE            EC=3.4.19.12;
GN   OrderedLocusNames=Os01g0851400, LOC_Os01g63250; ORFNames=P0529H11.31;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Interacts with key regulators of transcription and represses
CC       transcription. Acts as a histone-binding protein that regulates
CC       transcription. Acts as a deubiquitinating enzyme (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AP004072; BAB92851.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF06735.2; -; Genomic_DNA.
DR   EMBL; AP014957; BAS75251.1; -; Genomic_DNA.
DR   RefSeq; XP_015614266.1; XM_015758780.1.
DR   AlphaFoldDB; Q8LQ36; -.
DR   SMR; Q8LQ36; -.
DR   STRING; 39947.Q8LQ36; -.
DR   MEROPS; C86.A01; -.
DR   PaxDb; 39947-Q8LQ36; -.
DR   EnsemblPlants; Os01t0851400-01; Os01t0851400-01; Os01g0851400.
DR   GeneID; 4324808; -.
DR   Gramene; Os01t0851400-01; Os01t0851400-01; Os01g0851400.
DR   KEGG; osa:4324808; -.
DR   eggNOG; KOG2935; Eukaryota.
DR   HOGENOM; CLU_031228_0_1_1; -.
DR   InParanoid; Q8LQ36; -.
DR   OMA; RTERQMM; -.
DR   OrthoDB; 337428at2759; -.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.70.40; -; 1.
DR   Gene3D; 1.10.287.10; S15/NS1, RNA-binding; 1.
DR   InterPro; IPR033865; Ataxin-3.
DR   InterPro; IPR006155; Josephin.
DR   PANTHER; PTHR14159; ATAXIN-3-RELATED; 1.
DR   PANTHER; PTHR14159:SF0; ATAXIN-3-RELATED; 1.
DR   Pfam; PF02099; Josephin; 1.
DR   PRINTS; PR01233; JOSEPHIN.
DR   SMART; SM01246; Josephin; 1.
DR   PROSITE; PS50957; JOSEPHIN; 1.
DR   Genevisible; Q8LQ36; OS.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleus; Protease; Reference proteome; Thiol protease;
KW   Transcription; Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..336
FT                   /note="Putative ataxin-3 homolog"
FT                   /id="PRO_0000053837"
FT   DOMAIN          10..193
FT                   /note="Josephin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT   DOMAIN          244..263
FT                   /note="UIM"
FT                   /evidence="ECO:0000305"
FT   REGION          281..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        23
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT   ACT_SITE        132
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT   ACT_SITE        147
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
SQ   SEQUENCE   336 AA;  36205 MW;  84020FBEA78E8715 CRC64;
     MEEAAAASNG GLLYHEVQEG KLCAVHCVNT TLQGPFFSEF DLSALAVDLD QRERQVMSEG
     AAGAATTAAG DFLAEGEGSH NVSLGGDFSI QVLQKALEVW DLQVIPLDSP DVGSCLFDPE
     LETAFICHLQ DHWFCIRKVN GEWYNFNSLY PAPEHLSKFY LSAFIDTLKG SGWSIFAVRG
     NFPKECPMAT EGSNGFGQWL TPDDARRITS SCNQVQTPTQ QAGVSLVADQ SEEMSEMDMI
     AAQQEEADLN AAIAASLMDT GGPFANYAAH EESRSQDAFA IESTSGEMSK DGNLEEQGAN
     KSETSEPNSD NIESASGSNP KQNTTSLEGK ESIKED
//