Q8LQ36 (ATX3_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ataxin-3 homolog
EC=3.4.19.12

Gene names

Ordered Locus Names:	Os01g0851400, LOC_Os01g63250
ORF Names:	P0529H11.31

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 Josephin domain. Contains 1 UIM (ubiquitin-interacting motif) repeat.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW omega peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Putative ataxin-3 homolog		PRO_0000053837
Regions
	Domain	10 – 193	184	Josephin
	Repeat	244 – 263	20	UIM
Sites
	Active site	23	1	Nucleophile By similarity
	Active site	132	1	Proton acceptor By similarity
	Active site	147	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8LQ36 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 84020FBEA78E8715	FASTA	336	36,205
	10 20 30 40 50 60 MEEAAAASNG GLLYHEVQEG KLCAVHCVNT TLQGPFFSEF DLSALAVDLD QRERQVMSEG 70 80 90 100 110 120 AAGAATTAAG DFLAEGEGSH NVSLGGDFSI QVLQKALEVW DLQVIPLDSP DVGSCLFDPE 130 140 150 160 170 180 LETAFICHLQ DHWFCIRKVN GEWYNFNSLY PAPEHLSKFY LSAFIDTLKG SGWSIFAVRG 190 200 210 220 230 240 NFPKECPMAT EGSNGFGQWL TPDDARRITS SCNQVQTPTQ QAGVSLVADQ SEEMSEMDMI 250 260 270 280 290 300 AAQQEEADLN AAIAASLMDT GGPFANYAAH EESRSQDAFA IESTSGEMSK DGNLEEQGAN 310 320 330 KSETSEPNSD NIESASGSNP KQNTTSLEGK ESIKED

References

[1]

"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP004072 Genomic DNA. Translation: BAB92851.1.
RefSeq	NP_001044821.2. NM_001051356.2.
UniGene	Os.7799.
3D structure databases
ProteinModelPortal	Q8LQ36.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4324808.
KEGG	osa:4324808.
Organism-specific databases
Gramene	Q8LQ36.
Phylogenomic databases
eggNOG	NOG327234.
KO	K11863.
OMA	HCVNTTL.
ProtClustDB	CLSN2685078.
Family and domain databases
InterPro	IPR006155. Josephin. [Graphical view]
Pfam	PF02099. Josephin. 1 hit. [Graphical view]
PRINTS	PR01233. JOSEPHIN.
PROSITE	PS50957. JOSEPHIN. 1 hit. PS50330. UIM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATX3_ORYSJ

Accession

Primary (citable) accession number: Q8LQ36

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program