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Q8LPU5

- CMT3_MAIZE

UniProt

Q8LPU5 - CMT3_MAIZE

Protein

DNA (cytosine-5)-methyltransferase 3

Gene

DMT105

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May be involved in the CpXpG methylation and in gene silencing.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei521 – 5211PROSITE-ProRule annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    3. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin silencing Source: EnsemblPlants/Gramene
    2. DNA mediated transformation Source: EnsemblPlants/Gramene
    3. DNA methylation on cytosine within a CNG sequence Source: EnsemblPlants/Gramene
    4. histone H3-K9 methylation Source: EnsemblPlants/Gramene
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. zygote asymmetric cytokinesis in embryo sac Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi5016. M.ZmaV.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase 3 (EC:2.1.1.37)
    Alternative name(s):
    Chromomethylase 3
    DNA methyltransferase 105
    Gene namesi
    Name:DMT105
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiQ8LPU5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 915915DNA (cytosine-5)-methyltransferase 3PRO_0000246696Add
    BLAST

    Proteomic databases

    PRIDEiQ8LPU5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LPU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini188 – 313126BAHPROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 876532SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 50864ChromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 chromo domain.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    OMAiFGMASQG.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025821. C5_MeTfrase_pln.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF01426. BAH. 1 hit.
    PF00385. Chromo. 1 hit.
    PF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SMARTiSM00439. BAH. 1 hit.
    SM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 4 hits.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS51038. BAH. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8LPU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSSPSSAR PTRASGRKRS AMAEEIHQNQ EEEEEVVAAS TAKRRRKAAS    50
    SGKKPKPTPK QAKPAVAGMK KKGETEKTEP VVDDVCAEEP DEEELAMGEE 100
    EAEAEEQAMQ EVVAAVAAGS PGKKRVGRRS AAASGDHVPE FIGSPVAAAE 150
    AHSNWPKRYE RSTAANKPEE DDELKARCHY RSAKVDNIVY CLGDDVYVKA 200
    GENEADYIGR ITEFFEGTDR CHYFTCRWFF RAEDTVINSL VSINVDGHKH 250
    DPRRVFLSEE KNDNVLDCII SKVKIVHVDP NMDPKAKAQL IEHCDLYYDM 300
    SYSVAYSTFA NISSENGQSG SETASGISSD DAGLETSSNM PERTATLLDL 350
    YSGCGGMSTG LCLGAALSGL KLETRWAVDL NSFACQSLKY NHPQTEVRNE 400
    KADEFLALLK EWAVLCEKYV HQDVDSNLAG SEDQEDADTL DKDEFVVQKL 450
    IGIRYDGTGR KKGVYFKVQW EGYGPEEDTW EPIDNLSDCP LKIREFVQEG 500
    RKRKILPLPG DVDVICGGPP CQGISGFNRF RNRDEPLKDE KNKQMVTFMD 550
    IVAYLKPKYV LMENVVDILK FADGYLGKYA LSCLVAMKYQ ARLGMMVAGC 600
    YGLPQFRMRV FLWGALSSMV LPKYPLPTYD VVVRGGAPNA FSQCMVAYDE 650
    TQRPSLKKAL LLGDAFSDLP KVENHQPNDV MEYGGSPKTE FQRYIRLGRK 700
    DMLDWSFGEE AGPDEGKLLD HQPLRLNNDD YERVKQIPVK KGANFRDLKG 750
    VKVGANNVVE WDPEVERVYL SSGKPLVPDY AMSFIKGKSL KPFGRLWWDE 800
    TVPTVVTRAE PHNQVILHPT QARVLTIREN ARLQGFPDYY RLFGPIKEKY 850
    IQVGNAVAVP VARALGYCLG QAYLGESDGS QPLYQLPASF TSVGRTAVQA 900
    NAVSVGTPAG EVVEQ 915
    Length:915
    Mass (Da):101,611
    Last modified:October 1, 2002 - v1
    Checksum:iD1F4031F729C6A56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY093416 mRNA. Translation: AAM28227.1.
    UniGeneiZm.599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY093416 mRNA. Translation: AAM28227.1 .
    UniGenei Zm.599.

    3D structure databases

    ProteinModelPortali Q8LPU5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 5016. M.ZmaV.

    Proteomic databases

    PRIDEi Q8LPU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q8LPU5.

    Phylogenomic databases

    OMAi FGMASQG.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025821. C5_MeTfrase_pln.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF01426. BAH. 1 hit.
    PF00385. Chromo. 1 hit.
    PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SMARTi SM00439. BAH. 1 hit.
    SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 4 hits.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS51038. BAH. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences from the plant chromatin consortium."
      Chandler V.L., Kaeppler S.M., Kaeppler H.F., Cone K.C.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Bergstrom D., Springer N.M., Schmitt L.T., Guthrie E., Sidorenko L., Selinger D., Kaeppler S.M., Cone K.C.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCMT3_MAIZE
    AccessioniPrimary (citable) accession number: Q8LPU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3