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Protein

DNA (cytosine-5)-methyltransferase 3

Gene

DMT105

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the CpXpG methylation and in gene silencing.By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei521 – 5211PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Protein family/group databases

REBASEi5016. M.ZmaV.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 3 (EC:2.1.1.37)
Alternative name(s):
Chromomethylase 3
DNA methyltransferase 105
Gene namesi
Name:DMT105
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305 Componenti: Chromosome 2

Organism-specific databases

GrameneiQ8LPU5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915DNA (cytosine-5)-methyltransferase 3PRO_0000246696Add
BLAST

Proteomic databases

PRIDEiQ8LPU5.

Expressioni

Gene expression databases

ExpressionAtlasiQ8LPU5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G005310_P02.

Structurei

3D structure databases

ProteinModelPortaliQ8LPU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 313126BAHPROSITE-ProRule annotationAdd
BLAST
Domaini345 – 876532SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST
Domaini445 – 50864ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 chromo domain.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

OMAiANYMEDS.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LPU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSSPSSAR PTRASGRKRS AMAEEIHQNQ EEEEEVVAAS TAKRRRKAAS
60 70 80 90 100
SGKKPKPTPK QAKPAVAGMK KKGETEKTEP VVDDVCAEEP DEEELAMGEE
110 120 130 140 150
EAEAEEQAMQ EVVAAVAAGS PGKKRVGRRS AAASGDHVPE FIGSPVAAAE
160 170 180 190 200
AHSNWPKRYE RSTAANKPEE DDELKARCHY RSAKVDNIVY CLGDDVYVKA
210 220 230 240 250
GENEADYIGR ITEFFEGTDR CHYFTCRWFF RAEDTVINSL VSINVDGHKH
260 270 280 290 300
DPRRVFLSEE KNDNVLDCII SKVKIVHVDP NMDPKAKAQL IEHCDLYYDM
310 320 330 340 350
SYSVAYSTFA NISSENGQSG SETASGISSD DAGLETSSNM PERTATLLDL
360 370 380 390 400
YSGCGGMSTG LCLGAALSGL KLETRWAVDL NSFACQSLKY NHPQTEVRNE
410 420 430 440 450
KADEFLALLK EWAVLCEKYV HQDVDSNLAG SEDQEDADTL DKDEFVVQKL
460 470 480 490 500
IGIRYDGTGR KKGVYFKVQW EGYGPEEDTW EPIDNLSDCP LKIREFVQEG
510 520 530 540 550
RKRKILPLPG DVDVICGGPP CQGISGFNRF RNRDEPLKDE KNKQMVTFMD
560 570 580 590 600
IVAYLKPKYV LMENVVDILK FADGYLGKYA LSCLVAMKYQ ARLGMMVAGC
610 620 630 640 650
YGLPQFRMRV FLWGALSSMV LPKYPLPTYD VVVRGGAPNA FSQCMVAYDE
660 670 680 690 700
TQRPSLKKAL LLGDAFSDLP KVENHQPNDV MEYGGSPKTE FQRYIRLGRK
710 720 730 740 750
DMLDWSFGEE AGPDEGKLLD HQPLRLNNDD YERVKQIPVK KGANFRDLKG
760 770 780 790 800
VKVGANNVVE WDPEVERVYL SSGKPLVPDY AMSFIKGKSL KPFGRLWWDE
810 820 830 840 850
TVPTVVTRAE PHNQVILHPT QARVLTIREN ARLQGFPDYY RLFGPIKEKY
860 870 880 890 900
IQVGNAVAVP VARALGYCLG QAYLGESDGS QPLYQLPASF TSVGRTAVQA
910
NAVSVGTPAG EVVEQ
Length:915
Mass (Da):101,611
Last modified:October 1, 2002 - v1
Checksum:iD1F4031F729C6A56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093416 mRNA. Translation: AAM28227.1.
UniGeneiZm.599.

Genome annotation databases

EnsemblPlantsiGRMZM2G005310_T02; GRMZM2G005310_P02; GRMZM2G005310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093416 mRNA. Translation: AAM28227.1.
UniGeneiZm.599.

3D structure databases

ProteinModelPortaliQ8LPU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G005310_P02.

Protein family/group databases

REBASEi5016. M.ZmaV.

Proteomic databases

PRIDEiQ8LPU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM2G005310_T02; GRMZM2G005310_P02; GRMZM2G005310.

Organism-specific databases

GrameneiQ8LPU5.

Phylogenomic databases

OMAiANYMEDS.

Gene expression databases

ExpressionAtlasiQ8LPU5. baseline and differential.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences from the plant chromatin consortium."
    Chandler V.L., Kaeppler S.M., Kaeppler H.F., Cone K.C.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Bergstrom D., Springer N.M., Schmitt L.T., Guthrie E., Sidorenko L., Selinger D., Kaeppler S.M., Cone K.C.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCMT3_MAIZE
AccessioniPrimary (citable) accession number: Q8LPU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.