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Q8LPU5

- CMT3_MAIZE

UniProt

Q8LPU5 - CMT3_MAIZE

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Protein

DNA (cytosine-5)-methyltransferase 3

Gene

DMT105

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in the CpXpG methylation and in gene silencing.By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei521 – 5211PROSITE-ProRule annotation

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  3. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Protein family/group databases

REBASEi5016. M.ZmaV.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 3 (EC:2.1.1.37)
Alternative name(s):
Chromomethylase 3
DNA methyltransferase 105
Gene namesi
Name:DMT105
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiQ8LPU5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915DNA (cytosine-5)-methyltransferase 3PRO_0000246696Add
BLAST

Proteomic databases

PRIDEiQ8LPU5.

Structurei

3D structure databases

ProteinModelPortaliQ8LPU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 313126BAHPROSITE-ProRule annotationAdd
BLAST
Domaini345 – 876532SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST
Domaini445 – 50864ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 chromo domain.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

OMAiFGMASQG.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025821. C5_MeTfrase_pln.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
PF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LPU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSSPSSAR PTRASGRKRS AMAEEIHQNQ EEEEEVVAAS TAKRRRKAAS
60 70 80 90 100
SGKKPKPTPK QAKPAVAGMK KKGETEKTEP VVDDVCAEEP DEEELAMGEE
110 120 130 140 150
EAEAEEQAMQ EVVAAVAAGS PGKKRVGRRS AAASGDHVPE FIGSPVAAAE
160 170 180 190 200
AHSNWPKRYE RSTAANKPEE DDELKARCHY RSAKVDNIVY CLGDDVYVKA
210 220 230 240 250
GENEADYIGR ITEFFEGTDR CHYFTCRWFF RAEDTVINSL VSINVDGHKH
260 270 280 290 300
DPRRVFLSEE KNDNVLDCII SKVKIVHVDP NMDPKAKAQL IEHCDLYYDM
310 320 330 340 350
SYSVAYSTFA NISSENGQSG SETASGISSD DAGLETSSNM PERTATLLDL
360 370 380 390 400
YSGCGGMSTG LCLGAALSGL KLETRWAVDL NSFACQSLKY NHPQTEVRNE
410 420 430 440 450
KADEFLALLK EWAVLCEKYV HQDVDSNLAG SEDQEDADTL DKDEFVVQKL
460 470 480 490 500
IGIRYDGTGR KKGVYFKVQW EGYGPEEDTW EPIDNLSDCP LKIREFVQEG
510 520 530 540 550
RKRKILPLPG DVDVICGGPP CQGISGFNRF RNRDEPLKDE KNKQMVTFMD
560 570 580 590 600
IVAYLKPKYV LMENVVDILK FADGYLGKYA LSCLVAMKYQ ARLGMMVAGC
610 620 630 640 650
YGLPQFRMRV FLWGALSSMV LPKYPLPTYD VVVRGGAPNA FSQCMVAYDE
660 670 680 690 700
TQRPSLKKAL LLGDAFSDLP KVENHQPNDV MEYGGSPKTE FQRYIRLGRK
710 720 730 740 750
DMLDWSFGEE AGPDEGKLLD HQPLRLNNDD YERVKQIPVK KGANFRDLKG
760 770 780 790 800
VKVGANNVVE WDPEVERVYL SSGKPLVPDY AMSFIKGKSL KPFGRLWWDE
810 820 830 840 850
TVPTVVTRAE PHNQVILHPT QARVLTIREN ARLQGFPDYY RLFGPIKEKY
860 870 880 890 900
IQVGNAVAVP VARALGYCLG QAYLGESDGS QPLYQLPASF TSVGRTAVQA
910
NAVSVGTPAG EVVEQ
Length:915
Mass (Da):101,611
Last modified:October 1, 2002 - v1
Checksum:iD1F4031F729C6A56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY093416 mRNA. Translation: AAM28227.1.
UniGeneiZm.599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY093416 mRNA. Translation: AAM28227.1 .
UniGenei Zm.599.

3D structure databases

ProteinModelPortali Q8LPU5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 5016. M.ZmaV.

Proteomic databases

PRIDEi Q8LPU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q8LPU5.

Phylogenomic databases

OMAi FGMASQG.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025821. C5_MeTfrase_pln.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 4 hits.
SSF54160. SSF54160. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences from the plant chromatin consortium."
    Chandler V.L., Kaeppler S.M., Kaeppler H.F., Cone K.C.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Bergstrom D., Springer N.M., Schmitt L.T., Guthrie E., Sidorenko L., Selinger D., Kaeppler S.M., Cone K.C.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCMT3_MAIZE
AccessioniPrimary (citable) accession number: Q8LPU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3