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Protein

ABC transporter B family member 6

Gene

ABCB6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi447 – 454ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1193 – 1200ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G39480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 6
Short name:
ABC transporter ABCB.6
Short name:
AtABCB6
Alternative name(s):
Multidrug resistance protein 6
P-glycoprotein 6
Gene namesi
Name:ABCB6
Synonyms:MDR6, PGP6
Ordered Locus Names:At2g39480
ORF Names:F12L6.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G39480.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei139 – 159HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei212 – 231HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei236 – 258HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei310 – 330HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei840 – 860HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei880 – 900HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei958 – 978HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei982 – 1002HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1061 – 1081HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1102 – 1122HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279171 – 1407ABC transporter B family member 6Add BLAST1407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi663N-linked (GlcNAc...)Sequence analysis1
Glycosylationi727N-linked (GlcNAc...)Sequence analysis1
Glycosylationi767N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1346N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8LPT1.
PRIDEiQ8LPT1.

PTM databases

iPTMnetiQ8LPT1.

Expressioni

Gene expression databases

GenevisibleiQ8LPT1. AT.

Interactioni

Protein-protein interaction databases

BioGridi3871. 2 interactors.
STRINGi3702.AT2G39480.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LPT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 379ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST294
Domaini412 – 647ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini835 – 1123ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1158 – 1395ABC transporter 2PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ8LPT1.
KOiK05658.
OMAiHSFQEPS.
OrthoDBiEOG093600IW.
PhylomeDBiQ8LPT1.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LPT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMISRGLFGW SPPHIQPLTP VSEVSEPPES PSPYLDPGAE HGGTGTAAQA
60 70 80 90 100
DDEEEMEEPE EMEPPPAAVP FSQLFACADR FDWVLMVFGS VAAAAHGTAL
110 120 130 140 150
IVYLHYFAKI VQVLAFPTDS DHLISDDQFN RLLELSLTIV YIAGGVFISG
160 170 180 190 200
WIEVSCWILT GERQTAVIRS KYVQVLLNQD MSFFDTYGNN GDIVSQVLSD
210 220 230 240 250
VLLIQSALSE KVGNYIHNMA TFISGLIIGF VNCWEIALIT LATGPFIVAA
260 270 280 290 300
GGISNIFLHR LAENIQDAYA EAASIAEQAV SYVRTLYAFT NETLAKYSYA
310 320 330 340 350
TSLQATLRYG ILISLVQGLG LGFTYGLAIC SCAMQLWIGR FFVIHHRANG
360 370 380 390 400
GEIITALFAV ILSGLGLNQA ATNFYSFDQG RIAAYRLFEM ISRSSSGTNQ
410 420 430 440 450
EGIILSAVQG NIEFRNVYFS YLSRPEIPIL SGFYLTVPAK KAVALVGRNG
460 470 480 490 500
SGKSSIIPLM ERFYDPTLGE VLLDGENIKN LKLEWLRSQI GLVTQEPALL
510 520 530 540 550
SLSIRENIAY GRDATLDQIE EAAKKAHAHT FISSLEKGYE TQVGKTGLTL
560 570 580 590 600
TEEQKIKLSI ARAVLLDPTI LLLDEVTGGL DFEAERVVQE ALDLLMLGRS
610 620 630 640 650
TIIIARRLSL IRNADYIAVM EEGQLLEMGT HDELINLGNL YAELLKCEEA
660 670 680 690 700
TKLPRRMPVR NYNDSAAFQA ERDSSAGRGF QEPSSPKMAK SPSLQRGHNV
710 720 730 740 750
FRSQELCFNS EESPNDHSPA PEKLGENGSS LDVGEKEPTI KRQDSFEMRL
760 770 780 790 800
PELPKIDIQC PQRQKSNGSD PESPISPLLI SDPQNERSHS QTFSRPLGHS
810 820 830 840 850
DDTSASVKVA KDGQHKEPPS FWRLAQLSFP EWLYAVLGSI GAAIFGSFNP
860 870 880 890 900
LLAYVIALVV TTYYTSKGSH LREEVDKWCL IIACMGIVTV VANFLQHFYF
910 920 930 940 950
GIMGEKMTER VRRMMFSAML RNEVGWYDEE ENSPDTLSMR LANDATFVRA
960 970 980 990 1000
AFSNRLSIFI QDSFAVIVAI LIGLLLGWRL ALVALATLPV LTLSAIAQKL
1010 1020 1030 1040 1050
WLAGFSKGIQ EMHRKASLVL EDAVRNIYTV VAFCAGNKVM ELYRLQLQRI
1060 1070 1080 1090 1100
LRQSFFHGMA IGFAFGFSQF LLFACNALLL WYTALSVDRR YMKLSTALTE
1110 1120 1130 1140 1150
YMVFSFATFA LVEPFGLAPY ILKRRRSLAS VFEIIDRVPT IEPDDTSALS
1160 1170 1180 1190 1200
PPNVYGSIEL KNIDFCYPTR PEVLVLSNFS LKVNGGQTVA VVGVSGSGKS
1210 1220 1230 1240 1250
TIISLIERYY DPVAGQVLLD GRDLKSYNLR WLRSHMGLIQ QEPIIFSTTI
1260 1270 1280 1290 1300
RENIIYARHN ASEAEMKEAA RIANAHHFIS SLPHGYDTHI GMRGVELTQG
1310 1320 1330 1340 1350
QKQRIAIARV VLKNAPILLI DEASSSIESE SSRVVQEALD TLIMGNKTTI
1360 1370 1380 1390 1400
LIAHRVAMMR HVDNIVVLNG GKIVEEGTHD CLAGKNGLYV RLMQPHFGKN

LRRHQLI
Length:1,407
Mass (Da):155,876
Last modified:March 21, 2006 - v2
Checksum:i4148EA7252D9BCBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58E → G in AAM19777 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004218 Genomic DNA. Translation: AAC27839.1.
CP002685 Genomic DNA. Translation: AEC09685.1.
AY094398 mRNA. Translation: AAM19777.1.
PIRiT00558.
RefSeqiNP_181480.1. NM_129506.2.
UniGeneiAt.37167.
At.63501.

Genome annotation databases

EnsemblPlantsiAT2G39480.1; AT2G39480.1; AT2G39480.
GeneIDi818533.
GrameneiAT2G39480.1; AT2G39480.1; AT2G39480.
KEGGiath:AT2G39480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004218 Genomic DNA. Translation: AAC27839.1.
CP002685 Genomic DNA. Translation: AEC09685.1.
AY094398 mRNA. Translation: AAM19777.1.
PIRiT00558.
RefSeqiNP_181480.1. NM_129506.2.
UniGeneiAt.37167.
At.63501.

3D structure databases

ProteinModelPortaliQ8LPT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3871. 2 interactors.
STRINGi3702.AT2G39480.1.

PTM databases

iPTMnetiQ8LPT1.

Proteomic databases

PaxDbiQ8LPT1.
PRIDEiQ8LPT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G39480.1; AT2G39480.1; AT2G39480.
GeneIDi818533.
GrameneiAT2G39480.1; AT2G39480.1; AT2G39480.
KEGGiath:AT2G39480.

Organism-specific databases

TAIRiAT2G39480.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ8LPT1.
KOiK05658.
OMAiHSFQEPS.
OrthoDBiEOG093600IW.
PhylomeDBiQ8LPT1.

Enzyme and pathway databases

BioCyciARA:AT2G39480-MONOMER.

Miscellaneous databases

PROiQ8LPT1.

Gene expression databases

GenevisibleiQ8LPT1. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAB6B_ARATH
AccessioniPrimary (citable) accession number: Q8LPT1
Secondary accession number(s): O80635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.