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Protein

Monosaccharide-sensing protein 2

Gene

MSSP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.84. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monosaccharide-sensing protein 2
Alternative name(s):
Sugar transporter MSSP2
Gene namesi
Name:MSSP2
Ordered Locus Names:At4g35300
ORF Names:F23E12.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G35300.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei507 – 52721Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei553 – 57321Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei585 – 60521Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei610 – 63021Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei650 – 67021Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei679 – 69921Helical; Name=12Sequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: TAIR
  • integral component of plasma membrane Source: GO_Central
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Monosaccharide-sensing protein 2PRO_0000259883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei438 – 4381PhosphoserineBy similarity
Isoform 2 (identifier: Q8LPQ8-2)
Modified residuei448 – 4481PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8LPQ8.
PRIDEiQ8LPQ8.

PTM databases

iPTMnetiQ8LPQ8.
SwissPalmiQ8LPQ8.

Expressioni

Gene expression databases

ExpressionAtlasiQ8LPQ8. baseline and differential.
GenevisibleiQ8LPQ8. AT.

Interactioni

Protein-protein interaction databases

BioGridi14966. 8 interactions.
STRINGi3702.AT4G35300.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LPQ8.
SMRiQ8LPQ8. Positions 21-223, 494-706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
HOGENOMiHOG000238926.
InParanoidiQ8LPQ8.
OMAiAGVFGMY.
PhylomeDBiQ8LPQ8.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LPQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGAVLVAIA AAVGNLLQGW DNATIAGAVL YIKKEFNLES NPSVEGLIVA
60 70 80 90 100
MSLIGATLIT TCSGGVADWL GRRPMLILSS ILYFVGSLVM LWSPNVYVLL
110 120 130 140 150
LGRLLDGFGV GLVVTLVPIY ISETAPPEIR GLLNTLPQFT GSGGMFLSYC
160 170 180 190 200
MVFGMSLMPS PSWRLMLGVL FIPSLVFFFL TVFFLPESPR WLVSKGRMLE
210 220 230 240 250
AKRVLQRLRG REDVSGEMAL LVEGLGIGGE TTIEEYIIGP ADEVTDDHDI
260 270 280 290 300
AVDKDQIKLY GAEEGLSWVA RPVKGGSTMS VLSRHGSTMS RRQGSLIDPL
310 320 330 340 350
VTLFGSVHEK MPDTGSMRSA LFPHFGSMFS VGGNQPRHED WDEENLVGEG
360 370 380 390 400
EDYPSDHGDD SEDDLHSPLI SRQTTSMEKD MPHTAHGTLS TFRHGSQVQG
410 420 430 440 450
AQGEGAGSMG IGGGWQVAWK WTEREDESGQ KEEGFPGSRR GSIVSLPGGD
460 470 480 490 500
GTGEADFVQA SALVSQPALY SKDLLKEHTI GPAMVHPSET TKGSIWHDLH
510 520 530 540 550
DPGVKRALVV GVGLQILQQF SGINGVLYYT PQILEQAGVG ILLSNMGISS
560 570 580 590 600
SSASLLISAL TTFVMLPAIA VAMRLMDLSG RRTLLLTTIP ILIASLLVLV
610 620 630 640 650
ISNLVHMNSI VHAVLSTVSV VLYFCFFVMG FGPAPNILCS EIFPTRVRGI
660 670 680 690 700
CIAICALTFW ICDIIVTYSL PVLLKSIGLA GVFGMYAIVC CISWVFVFIK
710 720
VPETKGMPLE VITEFFSVGA RQAEAAKNE
Length:729
Mass (Da):78,525
Last modified:November 28, 2006 - v2
Checksum:i81A35DDF8725411E
GO
Isoform 2 (identifier: Q8LPQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-432: E → EGGFKRIYLHQ

Note: May be due to an intron retention. No experimental confirmation available.Combined sources
Show »
Length:739
Mass (Da):79,726
Checksum:i5D67C6D2DE7563FD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei432 – 4321E → EGGFKRIYLHQ in isoform 2. 1 PublicationVSP_021553

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532570 mRNA. Translation: CAD58692.1.
AL022604 Genomic DNA. Translation: CAA18739.1.
AL161587 Genomic DNA. Translation: CAB80247.1.
CP002687 Genomic DNA. Translation: AEE86493.1.
CP002687 Genomic DNA. Translation: AEE86494.1.
CP002687 Genomic DNA. Translation: AEE86495.1.
CP002687 Genomic DNA. Translation: AEE86497.1.
AY094465 mRNA. Translation: AAM19835.1.
PIRiT06127.
RefSeqiNP_001154287.1. NM_001160815.1. [Q8LPQ8-1]
NP_001190923.1. NM_001203994.1. [Q8LPQ8-2]
NP_195256.3. NM_119696.4. [Q8LPQ8-1]
NP_849565.1. NM_179234.1. [Q8LPQ8-2]
UniGeneiAt.27703.

Genome annotation databases

EnsemblPlantsiAT4G35300.2; AT4G35300.2; AT4G35300. [Q8LPQ8-1]
AT4G35300.3; AT4G35300.3; AT4G35300. [Q8LPQ8-1]
GeneIDi829684.
KEGGiath:AT4G35300.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532570 mRNA. Translation: CAD58692.1.
AL022604 Genomic DNA. Translation: CAA18739.1.
AL161587 Genomic DNA. Translation: CAB80247.1.
CP002687 Genomic DNA. Translation: AEE86493.1.
CP002687 Genomic DNA. Translation: AEE86494.1.
CP002687 Genomic DNA. Translation: AEE86495.1.
CP002687 Genomic DNA. Translation: AEE86497.1.
AY094465 mRNA. Translation: AAM19835.1.
PIRiT06127.
RefSeqiNP_001154287.1. NM_001160815.1. [Q8LPQ8-1]
NP_001190923.1. NM_001203994.1. [Q8LPQ8-2]
NP_195256.3. NM_119696.4. [Q8LPQ8-1]
NP_849565.1. NM_179234.1. [Q8LPQ8-2]
UniGeneiAt.27703.

3D structure databases

ProteinModelPortaliQ8LPQ8.
SMRiQ8LPQ8. Positions 21-223, 494-706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14966. 8 interactions.
STRINGi3702.AT4G35300.1.

Protein family/group databases

TCDBi2.A.1.1.84. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8LPQ8.
SwissPalmiQ8LPQ8.

Proteomic databases

PaxDbiQ8LPQ8.
PRIDEiQ8LPQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G35300.2; AT4G35300.2; AT4G35300. [Q8LPQ8-1]
AT4G35300.3; AT4G35300.3; AT4G35300. [Q8LPQ8-1]
GeneIDi829684.
KEGGiath:AT4G35300.

Organism-specific databases

TAIRiAT4G35300.

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
HOGENOMiHOG000238926.
InParanoidiQ8LPQ8.
OMAiAGVFGMY.
PhylomeDBiQ8LPQ8.

Miscellaneous databases

PROiQ8LPQ8.

Gene expression databases

ExpressionAtlasiQ8LPQ8. baseline and differential.
GenevisibleiQ8LPQ8. AT.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel family of plant monosaccharide transporters is involved in a new type of eukaryotic sugar sensing."
    Stamme C., Tjaden J., Trentmann O., Emmerlich V., Neuhaus E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  5. "The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages."
    Johnson D.A., Hill J.P., Thomas M.A.
    BMC Evol. Biol. 6:64-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  6. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
    Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
    J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: cv. Columbia.

Entry informationi

Entry nameiMSSP2_ARATH
AccessioniPrimary (citable) accession number: Q8LPQ8
Secondary accession number(s): O65497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.