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Protein

ABC transporter B family member 2

Gene

ABCB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi436 – 443ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1065 – 1072ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G25960-MONOMER.
ReactomeiR-ATH-159418. Recycling of bile acids and salts.
R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-ATH-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 2
Short name:
ABC transporter ABCB.2
Short name:
AtABCB2
Alternative name(s):
Multidrug resistance protein 2
P-glycoprotein 2
Gene namesi
Name:ABCB2
Synonyms:MDR2, PGP2
Ordered Locus Names:At4g25960
ORF Names:F20B18.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G25960.
TAIRilocus:2120805. AT4G25960.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei91 – 111HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei126 – 146HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei209 – 229HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei230 – 250HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei305 – 325HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei345 – 365HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei711 – 731HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei752 – 772HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei832 – 852HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei934 – 954HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei975 – 995HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000022791331 – 1273ABC transporter B family member 2Add BLAST1243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi806N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1256N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8LPK2.

PTM databases

iPTMnetiQ8LPK2.

Expressioni

Gene expression databases

GenevisibleiQ8LPK2. AT.

Interactioni

Subunit structurei

Interacts with 1-naphthylphthalamic acid (NPA).1 Publication

Protein-protein interaction databases

BioGridi13989. 1 interactor.
MINTiMINT-8061510.
STRINGi3702.AT4G25960.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LPK2.
SMRiQ8LPK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 366ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini401 – 637ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini710 – 997ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST288
Domaini1030 – 1266ABC transporter 2PROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ8LPK2.
KOiK05658.
OMAiFAVQWKL.
OrthoDBiEOG093600JM.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LPK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYISLIFFLS NHFPPLISIP IFIFLSFSSP TNYTHLKLKK MQPSGDPAPE
60 70 80 90 100
KEKEMTQPKV SLLKLFSFAD FYDCVLMTLG SVGACIHGAS VPIFFIFFGK
110 120 130 140 150
LINIIGLAYL FPKQASHRVA KYSLDFVYLS VAILFSSWLE VACWMHTGER
160 170 180 190 200
QAAKMRRAYL RSMLSQDISL FDTEASTGEV ISAITSDILV VQDALSEKVG
210 220 230 240 250
NFLHYISRFI AGFAIGFTSV WQISLVTLSI VPLIALAGGI YAFVAIGLIA
260 270 280 290 300
RVRKSYIKAG EIAEEVIGNV RTVQAFTGEE RAVRLYREAL ENTYKYGRKA
310 320 330 340 350
GLTKGLGLGS MHCVLFLSWA LLVWFTSVVV HKDIADGGKS FTTMLNVVIA
360 370 380 390 400
GLSLGQAAPD ISAFVRAKAA AYPIFKMIER NTVTKTSAKS GRKLGKVDGH
410 420 430 440 450
IQFKDATFSY PSRPDVVIFD RLNLAIPAGK IVALVGGSGS GKSTVISLIE
460 470 480 490 500
RFYEPISGAV LLDGNNISEL DIKWLRGQIG LVNQEPALFA TTIRENILYG
510 520 530 540 550
KDDATAEEIT RAAKLSEAIS FINNLPEGFE TQVGERGIQL SGGQKQRIAI
560 570 580 590 600
SRAIVKNPSI LLLDEATSAL DAESEKSVQE ALDRVMVGRT TVVVAHRLST
610 620 630 640 650
VRNADIIAVV HEGKIVEFGN HENLISNPDG AYSSLLRLQE TASLQRNPSL
660 670 680 690 700
NRTLSRPHSI KYSRELSRTR SSFCSERESV TRPDGADPSK KVKVTVGRLY
710 720 730 740 750
SMIRPDWMYG VCGTICAFIA GSQMPLFALG VSQALVSYYS GWDETQKEIK
760 770 780 790 800
KIAILFCCAS VITLIVYTIE HICFGTMGER LTLRVRENMF RAILKNEIGW
810 820 830 840 850
FDEVDNTSSM LASRLESDAT LLKTIVVDRS TILLQNLGLV VTSFIIAFIL
860 870 880 890 900
NWRLTLVVLA TYPLVISGHI SEKLFMQGYG GDLNKAYLKA NMLAGESVSN
910 920 930 940 950
IRTVAAFCAE EKILELYSRE LLEPSKSSFR RGQIAGLFYG VSQFFIFSSY
960 970 980 990 1000
GLALWYGSTL MDKGLAGFKS VMKTFMVLIV TALAMGETLA LAPDLLKGNQ
1010 1020 1030 1040 1050
MVASVFEILD RKTQIVGETS EELNNVEGTI ELKGVHFSYP SRPDVVIFRD
1060 1070 1080 1090 1100
FDLIVRAGKS MALVGQSGSG KSSVISLILR FYDPTAGKVM IEGKDIKKLD
1110 1120 1130 1140 1150
LKALRKHIGL VQQEPALFAT TIYENILYGN EGASQSEVVE SAMLANAHSF
1160 1170 1180 1190 1200
ITSLPEGYST KVGERGVQMS GGQRQRIAIA RAILKNPAIL LLDEATSALD
1210 1220 1230 1240 1250
VESERVVQQA LDRLMANRTT VVVAHRLSTI KNADTISVLH GGKIVEQGSH
1260 1270
RKLVLNKSGP YFKLISLQQQ QQP
Length:1,273
Mass (Da):139,909
Last modified:May 31, 2011 - v3
Checksum:iC3DE240E8B7885AB
GO

Sequence cautioni

The sequence AAM20507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA71276 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB39661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB79451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti807T → A in AAM20507 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10227 Genomic DNA. Translation: CAA71276.1. Different initiation.
Y10228 mRNA. Translation: CAA71277.1.
AL049483 Genomic DNA. Translation: CAB39661.1. Different initiation.
AL161564 Genomic DNA. Translation: CAB79451.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE85137.1.
AK227086 mRNA. Translation: BAE99138.1.
AY099656 mRNA. Translation: AAM20507.1. Different initiation.
PIRiT04251.
RefSeqiNP_194326.2. NM_118729.4.
UniGeneiAt.20799.
At.51557.

Genome annotation databases

EnsemblPlantsiAT4G25960.1; AT4G25960.1; AT4G25960.
GeneIDi828702.
GrameneiAT4G25960.1; AT4G25960.1; AT4G25960.
KEGGiath:AT4G25960.

Similar proteinsi

Entry informationi

Entry nameiAB2B_ARATH
AccessioniPrimary (citable) accession number: Q8LPK2
Secondary accession number(s): O04711, Q0WUR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 31, 2011
Last modified: June 7, 2017
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families