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Q8LPI9

- PAI3_ARATH

UniProt

Q8LPI9 - PAI3_ARATH

Protein

N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic

Gene

PAI3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: TAIR

    GO - Biological processi

    1. growth Source: TAIR
    2. multicellular organismal development Source: TAIR
    3. response to UV Source: TAIR
    4. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciARA:AT1G29410-MONOMER.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic (EC:5.3.1.24)
    Gene namesi
    Name:PAI3
    Ordered Locus Names:At1g29410
    ORF Names:F15D2.31
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G29410.

    Subcellular locationi

    Plastidchloroplast Curated

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232ChloroplastSequence AnalysisAdd
    BLAST
    Chaini33 – 244212N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplasticPRO_0000417455Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ8LPI9.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G29410.2-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LPI9.
    SMRiQ8LPI9. Positions 68-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000161598.
    InParanoidiQ8LPI9.
    KOiK01817.
    PhylomeDBiQ8LPI9.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8LPI9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTGISSDLH LHPRALNFSK TSKSGLSNRK VSFSSVGYAQ NRKLSCSVSS    50
    TENVAPKDDD RGKDRPLVKM CGITSARDAA MAVEAGADFI GMIIWPHSKR 100
    SISLSVAKDI SQVAREGGAK PVGVFVEDDE NTILRAADSS DLELVQLHGN 150
    SSRAAFSRLV RERKVIYVLN ANEDGKLLNV VPEEDGHLAD WILVDSATGG 200
    RYLDQLLSFF ALSHCNVFLR GTSYTITLVH ETVCLSQVTE ISRV 244
    Length:244
    Mass (Da):26,525
    Last modified:October 1, 2002 - v1
    Checksum:i451E286CCF6E3B40
    GO
    Isoform 2 (identifier: Q8LPI9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         202-213: YLDQLLSFFALS → FNHNNFLLWKRI
         214-244: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:213
    Mass (Da):23,221
    Checksum:i10C2087D0F5D358F
    GO

    Sequence cautioni

    The sequence AAC49004.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei202 – 21312YLDQL…FFALS → FNHNNFLLWKRI in isoform 2. 1 PublicationVSP_043745Add
    BLAST
    Alternative sequencei214 – 24431Missing in isoform 2. 1 PublicationVSP_043746Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18969 Genomic DNA. Translation: AAC49004.1. Sequence problems.
    AC068667 Genomic DNA. No translation available.
    CP002684 Genomic DNA. Translation: AEE31084.1.
    CP002684 Genomic DNA. Translation: AEE31085.1.
    AY072443 mRNA. Translation: AAL62435.1.
    AY099722 mRNA. Translation: AAM20573.1.
    BT000293 mRNA. Translation: AAN15612.1.
    RefSeqiNP_174234.3. NM_102681.3. [Q8LPI9-1]
    NP_850954.1. NM_180623.1. [Q8LPI9-2]
    UniGeneiAt.40744.

    Genome annotation databases

    EnsemblPlantsiAT1G29410.2; AT1G29410.2; AT1G29410. [Q8LPI9-1]
    GeneIDi839817.
    KEGGiath:AT1G29410.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18969 Genomic DNA. Translation: AAC49004.1 . Sequence problems.
    AC068667 Genomic DNA. No translation available.
    CP002684 Genomic DNA. Translation: AEE31084.1 .
    CP002684 Genomic DNA. Translation: AEE31085.1 .
    AY072443 mRNA. Translation: AAL62435.1 .
    AY099722 mRNA. Translation: AAM20573.1 .
    BT000293 mRNA. Translation: AAN15612.1 .
    RefSeqi NP_174234.3. NM_102681.3. [Q8LPI9-1 ]
    NP_850954.1. NM_180623.1. [Q8LPI9-2 ]
    UniGenei At.40744.

    3D structure databases

    ProteinModelPortali Q8LPI9.
    SMRi Q8LPI9. Positions 68-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G29410.2-P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G29410.2 ; AT1G29410.2 ; AT1G29410 . [Q8LPI9-1 ]
    GeneIDi 839817.
    KEGGi ath:AT1G29410.

    Organism-specific databases

    TAIRi AT1G29410.

    Phylogenomic databases

    HOGENOMi HOG000161598.
    InParanoidi Q8LPI9.
    KOi K01817.
    PhylomeDBi Q8LPI9.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci ARA:AT1G29410-MONOMER.

    Gene expression databases

    Genevestigatori Q8LPI9.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes."
      Li J., Zhao J., Rose A.B., Schmidt R., Last R.L.
      Plant Cell 7:447-461(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiPAI3_ARATH
    AccessioniPrimary (citable) accession number: Q8LPI9
    Secondary accession number(s): Q42528, Q8VY51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2012
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3