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Q8LPI9 (PAI3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic

EC=5.3.1.24
Gene names
Name:PAI3
Ordered Locus Names:At1g29410
ORF Names:F15D2.31
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135

Subcellular location

Plastidchloroplast Potential HAMAP-Rule MF_00135.

Sequence similarities

Belongs to the TrpF family.

Sequence caution

The sequence AAC49004.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8LPI9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8LPI9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     202-213: YLDQLLSFFALS → FNHNNFLLWKRI
     214-244: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3232Chloroplast Potential
Chain33 – 244212N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic HAMAP-Rule MF_00135
PRO_0000417455

Natural variations

Alternative sequence202 – 21312YLDQL…FFALS → FNHNNFLLWKRI in isoform 2.
VSP_043745
Alternative sequence214 – 24431Missing in isoform 2.
VSP_043746

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 451E286CCF6E3B40

FASTA24426,525
        10         20         30         40         50         60 
MSTGISSDLH LHPRALNFSK TSKSGLSNRK VSFSSVGYAQ NRKLSCSVSS TENVAPKDDD 

        70         80         90        100        110        120 
RGKDRPLVKM CGITSARDAA MAVEAGADFI GMIIWPHSKR SISLSVAKDI SQVAREGGAK 

       130        140        150        160        170        180 
PVGVFVEDDE NTILRAADSS DLELVQLHGN SSRAAFSRLV RERKVIYVLN ANEDGKLLNV 

       190        200        210        220        230        240 
VPEEDGHLAD WILVDSATGG RYLDQLLSFF ALSHCNVFLR GTSYTITLVH ETVCLSQVTE 


ISRV 

« Hide

Isoform 2 [UniParc].

Checksum: 10C2087D0F5D358F
Show »

FASTA21323,221

References

« Hide 'large scale' references
[1]"Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes."
Li J., Zhao J., Rose A.B., Schmidt R., Last R.L.
Plant Cell 7:447-461(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: cv. Columbia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18969 Genomic DNA. Translation: AAC49004.1. Sequence problems.
AC068667 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE31084.1.
CP002684 Genomic DNA. Translation: AEE31085.1.
AY072443 mRNA. Translation: AAL62435.1.
AY099722 mRNA. Translation: AAM20573.1.
BT000293 mRNA. Translation: AAN15612.1.
RefSeqNP_174234.3. NM_102681.3.
NP_850954.1. NM_180623.1.
UniGeneAt.40744.

3D structure databases

ProteinModelPortalQ8LPI9.
SMRQ8LPI9. Positions 66-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G29410.2-P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G29410.2; AT1G29410.2; AT1G29410. [Q8LPI9-1]
GeneID839817.
KEGGath:AT1G29410.

Organism-specific databases

TAIRAT1G29410.

Phylogenomic databases

HOGENOMHOG000161598.
InParanoidQ8LPI9.
KOK01817.
PhylomeDBQ8LPI9.
ProtClustDBPLN02363.

Enzyme and pathway databases

BioCycARA:AT1G29410-MONOMER.
UniPathwayUPA00035; UER00042.

Gene expression databases

GenevestigatorQ8LPI9.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00135. PRAI.
InterProIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAI3_ARATH
AccessionPrimary (citable) accession number: Q8LPI9
Secondary accession number(s): Q42528, Q8VY51
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names