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Q8LPI9

- PAI3_ARATH

UniProt

Q8LPI9 - PAI3_ARATH

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic
Gene
PAI3, At1g29410, F15D2.31
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. growth Source: TAIR
  2. multicellular organismal development Source: TAIR
  3. response to UV Source: TAIR
  4. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciARA:AT1G29410-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic (EC:5.3.1.24)
Gene namesi
Name:PAI3
Ordered Locus Names:At1g29410
ORF Names:F15D2.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G29410.

Subcellular locationi

Plastidchloroplast Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232Chloroplast Reviewed prediction
Add
BLAST
Chaini33 – 244212N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplasticUniRule annotation
PRO_0000417455Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ8LPI9.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G29410.2-P.

Structurei

3D structure databases

ProteinModelPortaliQ8LPI9.
SMRiQ8LPI9. Positions 68-179.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000161598.
InParanoidiQ8LPI9.
KOiK01817.
PhylomeDBiQ8LPI9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8LPI9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTGISSDLH LHPRALNFSK TSKSGLSNRK VSFSSVGYAQ NRKLSCSVSS    50
TENVAPKDDD RGKDRPLVKM CGITSARDAA MAVEAGADFI GMIIWPHSKR 100
SISLSVAKDI SQVAREGGAK PVGVFVEDDE NTILRAADSS DLELVQLHGN 150
SSRAAFSRLV RERKVIYVLN ANEDGKLLNV VPEEDGHLAD WILVDSATGG 200
RYLDQLLSFF ALSHCNVFLR GTSYTITLVH ETVCLSQVTE ISRV 244
Length:244
Mass (Da):26,525
Last modified:October 1, 2002 - v1
Checksum:i451E286CCF6E3B40
GO
Isoform 2 (identifier: Q8LPI9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-213: YLDQLLSFFALS → FNHNNFLLWKRI
     214-244: Missing.

Note: No experimental confirmation available.

Show »
Length:213
Mass (Da):23,221
Checksum:i10C2087D0F5D358F
GO

Sequence cautioni

The sequence AAC49004.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei202 – 21312YLDQL…FFALS → FNHNNFLLWKRI in isoform 2.
VSP_043745Add
BLAST
Alternative sequencei214 – 24431Missing in isoform 2.
VSP_043746Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18969 Genomic DNA. Translation: AAC49004.1. Sequence problems.
AC068667 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE31084.1.
CP002684 Genomic DNA. Translation: AEE31085.1.
AY072443 mRNA. Translation: AAL62435.1.
AY099722 mRNA. Translation: AAM20573.1.
BT000293 mRNA. Translation: AAN15612.1.
RefSeqiNP_174234.3. NM_102681.3. [Q8LPI9-1]
NP_850954.1. NM_180623.1. [Q8LPI9-2]
UniGeneiAt.40744.

Genome annotation databases

EnsemblPlantsiAT1G29410.2; AT1G29410.2; AT1G29410. [Q8LPI9-1]
GeneIDi839817.
KEGGiath:AT1G29410.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18969 Genomic DNA. Translation: AAC49004.1 . Sequence problems.
AC068667 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE31084.1 .
CP002684 Genomic DNA. Translation: AEE31085.1 .
AY072443 mRNA. Translation: AAL62435.1 .
AY099722 mRNA. Translation: AAM20573.1 .
BT000293 mRNA. Translation: AAN15612.1 .
RefSeqi NP_174234.3. NM_102681.3. [Q8LPI9-1 ]
NP_850954.1. NM_180623.1. [Q8LPI9-2 ]
UniGenei At.40744.

3D structure databases

ProteinModelPortali Q8LPI9.
SMRi Q8LPI9. Positions 68-179.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT1G29410.2-P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G29410.2 ; AT1G29410.2 ; AT1G29410 . [Q8LPI9-1 ]
GeneIDi 839817.
KEGGi ath:AT1G29410.

Organism-specific databases

TAIRi AT1G29410.

Phylogenomic databases

HOGENOMi HOG000161598.
InParanoidi Q8LPI9.
KOi K01817.
PhylomeDBi Q8LPI9.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci ARA:AT1G29410-MONOMER.

Gene expression databases

Genevestigatori Q8LPI9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes."
    Li J., Zhao J., Rose A.B., Schmidt R., Last R.L.
    Plant Cell 7:447-461(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: cv. Columbia.

Entry informationi

Entry nameiPAI3_ARATH
AccessioniPrimary (citable) accession number: Q8LPI9
Secondary accession number(s): Q42528, Q8VY51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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