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Protein

TSL-kinase interacting protein 1

Gene

TKI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSL-kinase interacting protein 1
Alternative name(s):
Myb-related protein TKI1
Gene namesi
Name:TKI1
Ordered Locus Names:At2g36960
ORF Names:T1J8.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G36960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002707961 – 743TSL-kinase interacting protein 1Add BLAST743

Post-translational modificationi

Phosphorylated in vitro by TOUSLED.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8LJT8

PTM databases

SwissPalmiQ8LJT8

Expressioni

Tissue specificityi

Expressed in flowers, roots and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LJT8 baseline and differential
GenevisibleiQ8LJT8 AT

Interactioni

Subunit structurei

Interacts only with active kinase forms of TOUSLED. Interacts with SNL1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TOUSLEDQ392384EBI-2366507,EBI-2325484

Protein-protein interaction databases

BioGridi3614, 4 interactors
IntActiQ8LJT8, 7 interactors
STRINGi3702.AT2G36960.3

Structurei

3D structure databases

ProteinModelPortaliQ8LJT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 104SANTPROSITE-ProRule annotationAdd BLAST52

Domaini

The Myb domain is not required for TOUSLED binding.

Phylogenomic databases

eggNOGiKOG4468 Eukaryota
ENOG4111TCZ LUCA
HOGENOMiHOG000239895
InParanoidiQ8LJT8
PhylomeDBiQ8LJT8

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LJT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKQFTHYCE MQAELIPEGP NGEGRLSNQN SNPNLLSSAS ISITQFPAKK
60 70 80 90 100
PTRQWAAWTH QEEESFFTAL RQVGKNFEKI TSRVQSKNKD QVRHYYYRLV
110 120 130 140 150
RRMNKLLGPD LSLDAKNPKD TNAAMLRWWS LLEKYSCKAS KLHLKPRRFK
160 170 180 190 200
LFIEALEHQL LKDRRKSIRK RTCQGENLSS ASLGNISSHS RERGLDNRPF
210 220 230 240 250
KLILSDGQNV KKLGPGRAST KHGESLSVNL GDEKEDTAFG RGGRQRRKQG
260 270 280 290 300
YRKWEKAAID GVSLVADAAE HLERTSIDKD MDDQTDLGPT RYLTGKSPLS
310 320 330 340 350
LCSAGDVPLS DANMQFSAKL KLQLFPIDEC TRRSLEMDKH NPHLELTLSN
360 370 380 390 400
RKKISSVLEH LNRKWGSSSC ATGELLLFPY NARKETVTCH QRWTHDSFLS
410 420 430 440 450
AAEVHSMVGS PSVFRLRYGW FVHDASGSII SQVPTSDPCP SLEDDMNVDR
460 470 480 490 500
LNEVNMLLTE SGPLSVHSTA EQTTSVEPSQ GLVCASGVHD RPARSRDDYE
510 520 530 540 550
PASTSITPLE HLSGGNAQSP GEWADSLTNI SIGDLLSEVP DDIDSDGVDP
560 570 580 590 600
PATEGSHYLL RDVPFTSDSF DAAIAAHILR HQNKPSAQLP LTSGSSSLWD
610 620 630 640 650
DEETRDAFSF QKNRFANSTE LASVASPKGV GRVNGEPSQL VEASSGDEGS
660 670 680 690 700
YNPHDDGDPM EEGPADPHTM DSPGKTPCGL ADVYWPDSLG PLDLDIRSSK
710 720 730 740
YTDDLILSES LGGLSRLIAT SLDAFQNCSL FGFDNKKDKS NMV
Length:743
Mass (Da):82,258
Last modified:January 9, 2007 - v2
Checksum:iB952325D7102ECCC
GO
Isoform 2 (identifier: Q8LJT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-287: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:741
Mass (Da):82,029
Checksum:iD91DA17A2DF39508
GO

Sequence cautioni

The sequence AAD31581 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2L → V in AAM94622 (PubMed:15047893).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022229286 – 287Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530160 mRNA Translation: AAM94622.1
AC006922 Genomic DNA Translation: AAD31581.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC09326.1
CP002685 Genomic DNA Translation: AEC09327.2
AY064068 mRNA Translation: AAL36424.1
AY096376 mRNA Translation: AAM20017.1
PIRiG84786
RefSeqiNP_001318368.1, NM_001336615.1 [Q8LJT8-1]
NP_850273.1, NM_179942.4 [Q8LJT8-1]
UniGeneiAt.27079

Genome annotation databases

EnsemblPlantsiAT2G36960.1; AT2G36960.1; AT2G36960 [Q8LJT8-1]
AT2G36960.2; AT2G36960.2; AT2G36960 [Q8LJT8-1]
GeneIDi818270
GrameneiAT2G36960.1; AT2G36960.1; AT2G36960 [Q8LJT8-1]
AT2G36960.2; AT2G36960.2; AT2G36960 [Q8LJT8-1]
KEGGiath:AT2G36960

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTKI1_ARATH
AccessioniPrimary (citable) accession number: Q8LJT8
Secondary accession number(s): Q3EBL6, Q8VZJ8, Q9SJL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 25, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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