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Protein

TSL-kinase interacting protein 1

Gene

TKI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TSL-kinase interacting protein 1
Alternative name(s):
Myb-related protein TKI1
Gene namesi
Name:TKI1
Ordered Locus Names:At2g36960
ORF Names:T1J8.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G36960.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743TSL-kinase interacting protein 1PRO_0000270796Add
BLAST

Post-translational modificationi

Phosphorylated in vitro by TOUSLED.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8LJT8.
PRIDEiQ8LJT8.

PTM databases

SwissPalmiQ8LJT8.

Expressioni

Tissue specificityi

Expressed in flowers, roots and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LJT8. baseline and differential.
GenevisibleiQ8LJT8. AT.

Interactioni

Subunit structurei

Interacts only with active kinase forms of TOUSLED. Interacts with SNL1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TOUSLEDQ392384EBI-2366507,EBI-2325484

Protein-protein interaction databases

BioGridi3614. 4 interactions.
IntActiQ8LJT8. 5 interactions.
STRINGi3702.AT2G36960.3.

Structurei

3D structure databases

ProteinModelPortaliQ8LJT8.
SMRiQ8LJT8. Positions 50-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 10452SANTPROSITE-ProRule annotationAdd
BLAST

Domaini

The Myb domain is not required for TOUSLED binding.

Sequence similaritiesi

Contains 1 SANT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4468. Eukaryota.
ENOG4111TCZ. LUCA.
HOGENOMiHOG000239895.
InParanoidiQ8LJT8.
PhylomeDBiQ8LJT8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LJT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKQFTHYCE MQAELIPEGP NGEGRLSNQN SNPNLLSSAS ISITQFPAKK
60 70 80 90 100
PTRQWAAWTH QEEESFFTAL RQVGKNFEKI TSRVQSKNKD QVRHYYYRLV
110 120 130 140 150
RRMNKLLGPD LSLDAKNPKD TNAAMLRWWS LLEKYSCKAS KLHLKPRRFK
160 170 180 190 200
LFIEALEHQL LKDRRKSIRK RTCQGENLSS ASLGNISSHS RERGLDNRPF
210 220 230 240 250
KLILSDGQNV KKLGPGRAST KHGESLSVNL GDEKEDTAFG RGGRQRRKQG
260 270 280 290 300
YRKWEKAAID GVSLVADAAE HLERTSIDKD MDDQTDLGPT RYLTGKSPLS
310 320 330 340 350
LCSAGDVPLS DANMQFSAKL KLQLFPIDEC TRRSLEMDKH NPHLELTLSN
360 370 380 390 400
RKKISSVLEH LNRKWGSSSC ATGELLLFPY NARKETVTCH QRWTHDSFLS
410 420 430 440 450
AAEVHSMVGS PSVFRLRYGW FVHDASGSII SQVPTSDPCP SLEDDMNVDR
460 470 480 490 500
LNEVNMLLTE SGPLSVHSTA EQTTSVEPSQ GLVCASGVHD RPARSRDDYE
510 520 530 540 550
PASTSITPLE HLSGGNAQSP GEWADSLTNI SIGDLLSEVP DDIDSDGVDP
560 570 580 590 600
PATEGSHYLL RDVPFTSDSF DAAIAAHILR HQNKPSAQLP LTSGSSSLWD
610 620 630 640 650
DEETRDAFSF QKNRFANSTE LASVASPKGV GRVNGEPSQL VEASSGDEGS
660 670 680 690 700
YNPHDDGDPM EEGPADPHTM DSPGKTPCGL ADVYWPDSLG PLDLDIRSSK
710 720 730 740
YTDDLILSES LGGLSRLIAT SLDAFQNCSL FGFDNKKDKS NMV
Length:743
Mass (Da):82,258
Last modified:January 9, 2007 - v2
Checksum:iB952325D7102ECCC
GO
Isoform 2 (identifier: Q8LJT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-287: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:741
Mass (Da):82,029
Checksum:iD91DA17A2DF39508
GO

Sequence cautioni

The sequence AAD31581 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21L → V in AAM94622 (PubMed:15047893).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei286 – 2872Missing in isoform 2. 1 PublicationVSP_022229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530160 mRNA. Translation: AAM94622.1.
AC006922 Genomic DNA. Translation: AAD31581.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC09326.1.
CP002685 Genomic DNA. Translation: AEC09327.1.
AY064068 mRNA. Translation: AAL36424.1.
AY096376 mRNA. Translation: AAM20017.1.
PIRiG84786.
RefSeqiNP_850273.1. NM_179942.3. [Q8LJT8-1]
NP_850274.1. NM_179943.2. [Q8LJT8-2]
UniGeneiAt.27079.

Genome annotation databases

EnsemblPlantsiAT2G36960.1; AT2G36960.1; AT2G36960. [Q8LJT8-1]
GeneIDi818270.
KEGGiath:AT2G36960.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530160 mRNA. Translation: AAM94622.1.
AC006922 Genomic DNA. Translation: AAD31581.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC09326.1.
CP002685 Genomic DNA. Translation: AEC09327.1.
AY064068 mRNA. Translation: AAL36424.1.
AY096376 mRNA. Translation: AAM20017.1.
PIRiG84786.
RefSeqiNP_850273.1. NM_179942.3. [Q8LJT8-1]
NP_850274.1. NM_179943.2. [Q8LJT8-2]
UniGeneiAt.27079.

3D structure databases

ProteinModelPortaliQ8LJT8.
SMRiQ8LJT8. Positions 50-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3614. 4 interactions.
IntActiQ8LJT8. 5 interactions.
STRINGi3702.AT2G36960.3.

PTM databases

SwissPalmiQ8LJT8.

Proteomic databases

PaxDbiQ8LJT8.
PRIDEiQ8LJT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G36960.1; AT2G36960.1; AT2G36960. [Q8LJT8-1]
GeneIDi818270.
KEGGiath:AT2G36960.

Organism-specific databases

TAIRiAT2G36960.

Phylogenomic databases

eggNOGiKOG4468. Eukaryota.
ENOG4111TCZ. LUCA.
HOGENOMiHOG000239895.
InParanoidiQ8LJT8.
PhylomeDBiQ8LJT8.

Miscellaneous databases

PROiQ8LJT8.

Gene expression databases

ExpressionAtlasiQ8LJT8. baseline and differential.
GenevisibleiQ8LJT8. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKI1_ARATH
AccessioniPrimary (citable) accession number: Q8LJT8
Secondary accession number(s): Q3EBL6, Q8VZJ8, Q9SJL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.