Q8LI34 (MYST1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative MYST-like histone acetyltransferase 1
EC=2.3.1.48

Gene names

Ordered Locus Names:	Os07g0626600, LOC_Os07g43360
ORF Names:	OJ1339_F05.128

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone acetyltransferase which may be involved in transcriptional activation By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus Probable.
Post-translational modification	Autoacetylation at Lys-274 is required for proper function By similarity.
Sequence similarities	Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. Contains 1 chromo domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Putative MYST-like histone acetyltransferase 1		PRO_0000238466
Regions
	Domain	77 – 137	61	Chromo
	Zinc finger	208 – 230	23	C2HC-type
	Region	324 – 330	7	Acetyl-CoA binding By similarity
	Compositional bias	6 – 38	33	Ala-rich
	Compositional bias	28 – 34	7	Poly-Gly
Sites
	Active site	274	1	By similarity
	Active site	316	1	Nucleophile By similarity
	Binding site	319	1	Acetyl-CoA By similarity
	Binding site	354	1	Acetyl-CoA By similarity
Amino acid modifications
	Modified residue	274	1	N6-acetyllysine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8LI34 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 18BABF1963015A34	FASTA	450	51,104
	10 20 30 40 50 60 MGSMEASTAP ENGTAAAAAA AASTACNGAG GGGGAAAASN GGGVERRLRS SAASASWASH 70 80 90 100 110 120 LPLEVGTRVM CRWRDQKLHP VKVIERRKSS TSSSPADYEY YVHYTEFNRR LDEWVKLEQL 130 140 150 160 170 180 DLETVETDVD EKVEDKATSL KMTRHQKRKI DETHVEQGHE ELDAASLREH EEFTKVKNIA 190 200 210 220 230 240 KIELGRYEID TWYFSPFPPE YNDSPKLFFC EFCLNFMKRK EQLQRHMKKC DLKHPPGDEI 250 260 270 280 290 300 YRSGTLSMFE VDGKKNKVYG QNLCYLAKLF LDHKTLYYDV DLFLFYVLCE CDDRGCHMVG 310 320 330 340 350 360 YFSKEKHSEE SYNLACILTL PPYQRKGYGK FLIAFSYELS KKEGKVGTPE RPLSDLGLLS 370 380 390 400 410 420 YRGYWTRVLL EILKKHKSNI SIKELSDMTA IKADDILSTL QSLDLIQYRK GQHVICADPK 430 440 450 VLDRHLKAAG RGGLEVDVSK LIWTPYKEQG

References

[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP004009 Genomic DNA. Translation: BAC07072.1.
RefSeq	NP_001060338.1. NM_001066873.1.
UniGene	Os.9844.
3D structure databases
ProteinModelPortal	Q8LI34.
SMR	Q8LI34. Positions 177-445.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os07g43360.1; LOC_Os07g43360.1; LOC_Os07g43360.
GeneID	4343971.
KEGG	osa:4343971.
Organism-specific databases
Gramene	Q8LI34.
Phylogenomic databases
eggNOG	COG5027.
HOGENOM	HOG000182457.
KO	K11308.
OMA	EEDEKGH.
ProtClustDB	PLN00104.
Gene expression databases
ArrayExpress	Q8LI34.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR002717. MOZ_SAS. IPR025995. Tudor-knot. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF01853. MOZ_SAS. 1 hit. PF11717. Tudor-knot. 1 hit. [Graphical view]
SMART	SM00298. CHROMO. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit. SSF54160. Chromodomain-like. 1 hit.
PROSITE	PS00598. CHROMO_1. False negative. PS50013. CHROMO_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYST1_ORYSJ

Accession

Primary (citable) accession number: Q8LI34

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program