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Protein

Hexokinase-1

Gene

HXK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme.1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 111ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.
ReactomeiR-OSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-70153. Glucose transport.
R-OSA-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Gene namesi
Name:HXK1
Ordered Locus Names:Os07g0446800, LOC_Os07g26540
ORF Names:P0030H06.133, P0475E07.113
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475641 – 498Hexokinase-1Add BLAST498

Proteomic databases

PaxDbiQ8LH82.

Expressioni

Gene expression databases

GenevisibleiQ8LH82. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os07g26540.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LH82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 492HexokinasePROSITE-ProRule annotationAdd BLAST454

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 233Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni176 – 202Glucose-bindingSequence analysisAdd BLAST27
Regioni234 – 481Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST248

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 75Ala-richAdd BLAST74

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ8LH82.
KOiK00844.
OMAiRRCMESA.
OrthoDBiEOG093608SG.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LH82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAADQ KVVTMTSLRE GCACAAPPAA AAPPMPKMAA AQRVVAELRE
60 70 80 90 100
ACATPAARLA EVAAAMAGEM EAGLAVEGGS SEMKMIVSYV DSLPTGGEEG
110 120 130 140 150
SYYALDLGGT NFRVLRVRLA GGGVAERVAR EVPIPPGLMS GGGATSECLF
160 170 180 190 200
GFIASALAEF VGEEEEEGGL DGGERELGFT FSFPVHQTSI ASGTLIRWTK
210 220 230 240 250
AFAVDDAIGE DVVAALQAAM SERGLDMRVS ALINDTVGTL AAGSYYDEDV
260 270 280 290 300
VAAVILGTGT NAAYVEDATA IAKLHPSQLP ASNTMVINTE WGSFASPCLP
310 320 330 340 350
LTEFDEALDQ ESLNPGEQTY EKLISGMYLG EIVRRVLLKI SSRCPSLLGG
360 370 380 390 400
AGELATPFVL RTPDVSAMHH DETPDLSIVG EKLERTLGIR GTSPEARRMV
410 420 430 440 450
VEVCDIVATR AARLAAAGIV GILKKIGRVD GGEGRRRRSV VAVDGGLFEH
460 470 480 490
YGKFRRCMES AVRELLGEAA AERVVVKLAS DGSGLGAALV AAAHSQRA
Length:498
Mass (Da):51,772
Last modified:October 1, 2002 - v1
Checksum:i6DC7BD48B62C985E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116383 mRNA. Translation: AAZ93618.1.
AY884164 mRNA. Translation: AAX68417.1.
AP004395 Genomic DNA. Translation: BAC10209.1.
AP004668 Genomic DNA. Translation: BAC16101.1.
AP008213 Genomic DNA. Translation: BAF21452.1.
AP014963 Genomic DNA. Translation: BAT01294.1.
RefSeqiXP_015645221.1. XM_015789735.1.
UniGeneiOs.89976.

Genome annotation databases

EnsemblPlantsiOS07T0446800-00; OS07T0446800-00; OS07G0446800.
GeneIDi4343113.
GrameneiOS07T0446800-00; OS07T0446800-00; OS07G0446800.
KEGGiosa:4343113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116383 mRNA. Translation: AAZ93618.1.
AY884164 mRNA. Translation: AAX68417.1.
AP004395 Genomic DNA. Translation: BAC10209.1.
AP004668 Genomic DNA. Translation: BAC16101.1.
AP008213 Genomic DNA. Translation: BAF21452.1.
AP014963 Genomic DNA. Translation: BAT01294.1.
RefSeqiXP_015645221.1. XM_015789735.1.
UniGeneiOs.89976.

3D structure databases

ProteinModelPortaliQ8LH82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os07g26540.1.

Proteomic databases

PaxDbiQ8LH82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS07T0446800-00; OS07T0446800-00; OS07G0446800.
GeneIDi4343113.
GrameneiOS07T0446800-00; OS07T0446800-00; OS07G0446800.
KEGGiosa:4343113.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ8LH82.
KOiK00844.
OMAiRRCMESA.
OrthoDBiEOG093608SG.

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.
ReactomeiR-OSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-70153. Glucose transport.
R-OSA-70171. Glycolysis.

Gene expression databases

GenevisibleiQ8LH82. OS.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXK1_ORYSJ
AccessioniPrimary (citable) accession number: Q8LH82
Secondary accession number(s): Q0D6S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.