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Protein

Hexokinase-1

Gene

HXK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme.1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 111ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1 4460
ReactomeiR-OSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-OSA-6798695 Neutrophil degranulation
R-OSA-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Gene namesi
Name:HXK1
Ordered Locus Names:Os07g0446800, LOC_Os07g26540
ORF Names:P0030H06.133, P0475E07.113
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475641 – 498Hexokinase-1Add BLAST498

Proteomic databases

PaxDbiQ8LH82
PRIDEiQ8LH82

Expressioni

Gene expression databases

ExpressionAtlasiQ8LH82 differential
GenevisibleiQ8LH82 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os07g26540.1

Structurei

3D structure databases

ProteinModelPortaliQ8LH82
SMRiQ8LH82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 492HexokinasePROSITE-ProRule annotationAdd BLAST454

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 233Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni176 – 202Glucose-bindingSequence analysisAdd BLAST27
Regioni234 – 481Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST248

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 75Ala-richAdd BLAST74

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
HOGENOMiHOG000162670
InParanoidiQ8LH82
KOiK00844
OMAiTEWGSFA
OrthoDBiEOG093608SG

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LH82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAADQ KVVTMTSLRE GCACAAPPAA AAPPMPKMAA AQRVVAELRE
60 70 80 90 100
ACATPAARLA EVAAAMAGEM EAGLAVEGGS SEMKMIVSYV DSLPTGGEEG
110 120 130 140 150
SYYALDLGGT NFRVLRVRLA GGGVAERVAR EVPIPPGLMS GGGATSECLF
160 170 180 190 200
GFIASALAEF VGEEEEEGGL DGGERELGFT FSFPVHQTSI ASGTLIRWTK
210 220 230 240 250
AFAVDDAIGE DVVAALQAAM SERGLDMRVS ALINDTVGTL AAGSYYDEDV
260 270 280 290 300
VAAVILGTGT NAAYVEDATA IAKLHPSQLP ASNTMVINTE WGSFASPCLP
310 320 330 340 350
LTEFDEALDQ ESLNPGEQTY EKLISGMYLG EIVRRVLLKI SSRCPSLLGG
360 370 380 390 400
AGELATPFVL RTPDVSAMHH DETPDLSIVG EKLERTLGIR GTSPEARRMV
410 420 430 440 450
VEVCDIVATR AARLAAAGIV GILKKIGRVD GGEGRRRRSV VAVDGGLFEH
460 470 480 490
YGKFRRCMES AVRELLGEAA AERVVVKLAS DGSGLGAALV AAAHSQRA
Length:498
Mass (Da):51,772
Last modified:October 1, 2002 - v1
Checksum:i6DC7BD48B62C985E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116383 mRNA Translation: AAZ93618.1
AY884164 mRNA Translation: AAX68417.1
AP004395 Genomic DNA Translation: BAC10209.1
AP004668 Genomic DNA Translation: BAC16101.1
AP008213 Genomic DNA Translation: BAF21452.1
AP014963 Genomic DNA Translation: BAT01294.1
RefSeqiXP_015645221.1, XM_015789735.1
UniGeneiOs.89976

Genome annotation databases

EnsemblPlantsiOs07t0446800-00; Os07t0446800-00; Os07g0446800
GeneIDi4343113
GrameneiOs07t0446800-00; Os07t0446800-00; Os07g0446800
KEGGiosa:4343113

Similar proteinsi

Entry informationi

Entry nameiHXK1_ORYSJ
AccessioniPrimary (citable) accession number: Q8LH82
Secondary accession number(s): Q0D6S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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