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Q8LH82 (HXK1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-1

EC=2.7.1.1
Gene names
Name:HXK1
Ordered Locus Names:Os07g0446800, LOC_Os07g26540
ORF Names:P0030H06.133, P0475E07.113
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fructose and glucose phosphorylating enzyme. Ref.1

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Hexokinase-1
PRO_0000247564

Regions

Domain42 – 245204Hexokinase type-1
Domain254 – 493240Hexokinase type-2
Nucleotide binding106 – 1116ATP Potential
Region176 – 20227Glucose-binding Potential
Compositional bias2 – 7574Ala-rich

Sequences

Sequence LengthMass (Da)Tools
Q8LH82 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6DC7BD48B62C985E

FASTA49851,772
        10         20         30         40         50         60 
MAAAAVAADQ KVVTMTSLRE GCACAAPPAA AAPPMPKMAA AQRVVAELRE ACATPAARLA 

        70         80         90        100        110        120 
EVAAAMAGEM EAGLAVEGGS SEMKMIVSYV DSLPTGGEEG SYYALDLGGT NFRVLRVRLA 

       130        140        150        160        170        180 
GGGVAERVAR EVPIPPGLMS GGGATSECLF GFIASALAEF VGEEEEEGGL DGGERELGFT 

       190        200        210        220        230        240 
FSFPVHQTSI ASGTLIRWTK AFAVDDAIGE DVVAALQAAM SERGLDMRVS ALINDTVGTL 

       250        260        270        280        290        300 
AAGSYYDEDV VAAVILGTGT NAAYVEDATA IAKLHPSQLP ASNTMVINTE WGSFASPCLP 

       310        320        330        340        350        360 
LTEFDEALDQ ESLNPGEQTY EKLISGMYLG EIVRRVLLKI SSRCPSLLGG AGELATPFVL 

       370        380        390        400        410        420 
RTPDVSAMHH DETPDLSIVG EKLERTLGIR GTSPEARRMV VEVCDIVATR AARLAAAGIV 

       430        440        450        460        470        480 
GILKKIGRVD GGEGRRRRSV VAVDGGLFEH YGKFRRCMES AVRELLGEAA AERVVVKLAS 

       490 
DGSGLGAALV AAAHSQRA 

« Hide

References

« Hide 'large scale' references
[1]"Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, NOMENCLATURE.
Strain: cv. Jinmi.
[2]"The hexokinase gene family in rice."
Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Zhonghua 15.
Tissue: Flower.
[3]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ116383 mRNA. Translation: AAZ93618.1.
AY884164 mRNA. Translation: AAX68417.1.
AP004395 Genomic DNA. Translation: BAC10209.1.
AP004668 Genomic DNA. Translation: BAC16101.1.
RefSeqNP_001059538.1. NM_001066073.1.
UniGeneOs.89976.

3D structure databases

ProteinModelPortalQ8LH82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os07g26540.1.

Proteomic databases

PRIDEQ8LH82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS07T0446800-00; OS07T0446800-00; OS07G0446800.
GeneID4343113.
KEGGosa:4343113.

Organism-specific databases

GrameneQ8LH82.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
KOK00844.
OMAEMCINTE.

Enzyme and pathway databases

BRENDA2.7.1.1. 4460.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
ProtoNetSearch...

Entry information

Entry nameHXK1_ORYSJ
AccessionPrimary (citable) accession number: Q8LH82
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations