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Q8LH82

- HXK1_ORYSJ

UniProt

Q8LH82 - HXK1_ORYSJ

Protein

Hexokinase-1

Gene

HXK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme.1 Publication

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi106 – 1116ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.1. 4460.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-1 (EC:2.7.1.1)
    Gene namesi
    Name:HXK1
    Ordered Locus Names:Os07g0446800, LOC_Os07g26540
    ORF Names:P0030H06.133, P0475E07.113
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 7

    Organism-specific databases

    GrameneiQ8LH82.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Hexokinase-1PRO_0000247564Add
    BLAST

    Proteomic databases

    PRIDEiQ8LH82.

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os07g26540.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LH82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 245204Hexokinase type-1Add
    BLAST
    Domaini254 – 493240Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 20227Glucose-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 7574Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    KOiK00844.
    OMAiGENICHL.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    Q8LH82-1 [UniParc]FASTAAdd to Basket

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    MAAAAVAADQ KVVTMTSLRE GCACAAPPAA AAPPMPKMAA AQRVVAELRE    50
    ACATPAARLA EVAAAMAGEM EAGLAVEGGS SEMKMIVSYV DSLPTGGEEG 100
    SYYALDLGGT NFRVLRVRLA GGGVAERVAR EVPIPPGLMS GGGATSECLF 150
    GFIASALAEF VGEEEEEGGL DGGERELGFT FSFPVHQTSI ASGTLIRWTK 200
    AFAVDDAIGE DVVAALQAAM SERGLDMRVS ALINDTVGTL AAGSYYDEDV 250
    VAAVILGTGT NAAYVEDATA IAKLHPSQLP ASNTMVINTE WGSFASPCLP 300
    LTEFDEALDQ ESLNPGEQTY EKLISGMYLG EIVRRVLLKI SSRCPSLLGG 350
    AGELATPFVL RTPDVSAMHH DETPDLSIVG EKLERTLGIR GTSPEARRMV 400
    VEVCDIVATR AARLAAAGIV GILKKIGRVD GGEGRRRRSV VAVDGGLFEH 450
    YGKFRRCMES AVRELLGEAA AERVVVKLAS DGSGLGAALV AAAHSQRA 498
    Length:498
    Mass (Da):51,772
    Last modified:October 1, 2002 - v1
    Checksum:i6DC7BD48B62C985E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116383 mRNA. Translation: AAZ93618.1.
    AY884164 mRNA. Translation: AAX68417.1.
    AP004395 Genomic DNA. Translation: BAC10209.1.
    AP004668 Genomic DNA. Translation: BAC16101.1.
    RefSeqiNP_001059538.1. NM_001066073.1.
    UniGeneiOs.89976.

    Genome annotation databases

    EnsemblPlantsiOS07T0446800-00; OS07T0446800-00; OS07G0446800.
    GeneIDi4343113.
    KEGGiosa:4343113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116383 mRNA. Translation: AAZ93618.1 .
    AY884164 mRNA. Translation: AAX68417.1 .
    AP004395 Genomic DNA. Translation: BAC10209.1 .
    AP004668 Genomic DNA. Translation: BAC16101.1 .
    RefSeqi NP_001059538.1. NM_001066073.1.
    UniGenei Os.89976.

    3D structure databases

    ProteinModelPortali Q8LH82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os07g26540.1.

    Proteomic databases

    PRIDEi Q8LH82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS07T0446800-00 ; OS07T0446800-00 ; OS07G0446800 .
    GeneIDi 4343113.
    KEGGi osa:4343113.

    Organism-specific databases

    Gramenei Q8LH82.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    KOi K00844.
    OMAi GENICHL.

    Enzyme and pathway databases

    BRENDAi 2.7.1.1. 4460.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
      Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
      Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, NOMENCLATURE.
      Strain: cv. Jinmi.
    2. "The hexokinase gene family in rice."
      Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Zhonghua 15.
      Tissue: Flower.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHXK1_ORYSJ
    AccessioniPrimary (citable) accession number: Q8LH82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3