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Protein

Cell division cycle protein 27 homolog B

Gene

CDC27B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication. Functionally redundant with CDC27A in the control of gametophyte development.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell differentiation Source: TAIR
  • cell division Source: UniProtKB-KW
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of mitotic cell cycle Source: TAIR
  • response to auxin Source: TAIR
  • root cap development Source: TAIR
  • root development Source: TAIR
  • root meristem specification Source: TAIR

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 27 homolog B
Short name:
CDC27 homolog B
Alternative name(s):
Protein HOBBIT
Gene namesi
Name:CDC27B
Synonyms:HBT
Ordered Locus Names:At2g20000
ORF Names:T2G17.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G20000
TAIRilocus:2061649 AT2G20000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Dwarf plant with small leaves and stunted growth. Defect in cell division and expansion. Defective endoreduplication. Cdc27a and cdc27b double mutant is gametophytic lethal (PubMed:17944809).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003968401 – 744Cell division cycle protein 27 homolog BAdd BLAST744

Proteomic databases

PaxDbiQ8LGU6

PTM databases

iPTMnetiQ8LGU6

Expressioni

Tissue specificityi

Specifically expressed in dividing and elongating cells.1 Publication

Gene expression databases

ExpressionAtlasiQ8LGU6 baseline and differential
GenevisibleiQ8LGU6 AT

Interactioni

Subunit structurei

The APC/C is composed of at least 10 subunits (By similarity). Can homodimerize (By similarity). Interacts with APC2, APC10, FZR2 and FZR3 (PubMed:17944809). Interacts with PANS1 (PubMed:24206843). Interacts with SAMBA (PubMed:22869741).By similarity3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1874, 18 interactors
ELMiQ8LGU6
IntActiQ8LGU6, 21 interactors
STRINGi3702.AT2G20000.1

Structurei

3D structure databases

ProteinModelPortaliQ8LGU6
SMRiQ8LGU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 134TPR 1Add BLAST34
Repeati450 – 483TPR 2Add BLAST34
Repeati518 – 551TPR 3Add BLAST34
Repeati553 – 585TPR 4Add BLAST33
Repeati587 – 619TPR 5Add BLAST33
Repeati621 – 653TPR 6Add BLAST33
Repeati655 – 687TPR 7Add BLAST33
Repeati688 – 721TPR 8Add BLAST34

Sequence similaritiesi

Belongs to the APC3/CDC27 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1126 Eukaryota
COG0457 LUCA
HOGENOMiHOG000231056
InParanoidiQ8LGU6
KOiK03350
OMAiMPLTSPC
OrthoDBiEOG093604S0
PhylomeDBiQ8LGU6

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q8LGU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMLVDCVN NSLRHFVYKN AIFMCERLCA EFPSEVNLQL LATSYLQNNQ
60 70 80 90 100
AYSAYHLLKG TQMAQSRYLF ALSCFQMDLL NEAESALCPV NEPGAEIPNG
110 120 130 140 150
AAGHYLLGLI YKYTDRRKNA AQQFKQSLTI DPLLWAAYEE LCILGAAEEA
160 170 180 190 200
TAVFGETAAL SIQKQYMQQL STSLGLNTYN EERNSTSTKN TSSEDYSPRQ
210 220 230 240 250
SKHTQSHGLK DISGNFHSHG VNGGVSNMSF YNTPSPVAAQ LSGIAPPPLF
260 270 280 290 300
RNFQPAVANP NSLITDSSPK STVNSTLQAP RRKFVDEGKL RKISGRLFSD
310 320 330 340 350
SGPRRSSRLS ADSGANINSS VATVSGNVNN ASKYLGGSKL SSLALRSVTL
360 370 380 390 400
RKGHSWANEN MDEGVRGEPF DDSRPNTAST TGSMASNDQE DETMSIGGIA
410 420 430 440 450
MSSQTITIGV SEILNLLRTL GEGCRLSYMY RCQEALDTYM KLPHKHYNTG
460 470 480 490 500
WVLSQVGKAY FELIDYLEAE KAFRLARLAS PYCLEGMDIY STVLYHLKED
510 520 530 540 550
MKLSYLAQEL ISTDRLAPQS WCAMGNCYSL QKDHETALKN FLRAVQLNPR
560 570 580 590 600
FAYAHTLCGH EYTTLEDFEN GMKSYQNALR VDTRHYNAWY GLGMIYLRQE
610 620 630 640 650
KLEFSEHHFR MAFLINPSSS VIMSYLGTSL HALKRSEEAL EIMEQAIVAD
660 670 680 690 700
RKNPLPMYQK ANILVCLERL DEALEVLEEL KEYAPSESSV YALMGRIYKR
710 720 730 740
RNMHDKAMLH FGLALDMKPP ATDVAAIKAA MEKLHVPDEI DESP
Length:744
Mass (Da):83,068
Last modified:October 1, 2002 - v1
Checksum:i1CB1719C75469861
GO

Sequence cautioni

The sequence AAD24396 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL32548 differs from that shown. Intron retention.Curated
The sequence AAM91180 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487669 mRNA Translation: CAD31951.1
AC006081 Genomic DNA Translation: AAD24396.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06953.1
AY062470 mRNA Translation: AAL32548.1 Sequence problems.
AY128780 mRNA Translation: AAM91180.1 Sequence problems.
PIRiG84583
RefSeqiNP_849994.1, NM_179663.3
UniGeneiAt.39758

Genome annotation databases

EnsemblPlantsiAT2G20000.1; AT2G20000.1; AT2G20000
GeneIDi816519
GrameneiAT2G20000.1; AT2G20000.1; AT2G20000
KEGGiath:AT2G20000

Similar proteinsi

Entry informationi

Entry nameiCD27B_ARATH
AccessioniPrimary (citable) accession number: Q8LGU6
Secondary accession number(s): Q8W4M8, Q9SL81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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