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Protein

ABC transporter C family member 8

Gene

ABCC8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi633 – 640ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1249 – 1256ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 8 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.8
Short name:
AtABCC8
Alternative name(s):
ATP-energized glutathione S-conjugate pump 6
Glutathione S-conjugate-transporting ATPase 6
Multidrug resistance-associated protein 6
Gene namesi
Name:ABCC8
Synonyms:MRP6, MRP8
Ordered Locus Names:At3g21250
ORF Names:MXL8.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G21250
TAIRilocus:2094721 AT3G21250

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei61 – 81HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei94 – 114HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei123 – 143HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei152 – 172HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei203 – 223HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei283 – 303HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei321 – 343HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei391 – 411HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei413 – 433HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei508 – 528HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei909 – 929HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei931 – 951HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1008 – 1028HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1030 – 1050HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1132 – 1152HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022607723 – 1464ABC transporter C family member 8Add BLAST1442

Proteomic databases

PaxDbiQ8LGU1
PRIDEiQ8LGU1

PTM databases

iPTMnetiQ8LGU1

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ8LGU1 baseline and differential
GenevisibleiQ8LGU1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G21250.2

Structurei

3D structure databases

ProteinModelPortaliQ8LGU1
SMRiQ8LGU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 564ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST283
Domaini600 – 821ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini901 – 1178ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST278
Domaini1215 – 1449ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ8LGU1
OMAiEYIGACV
OrthoDBiEOG093600BB

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LGU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAFIGSLPW CDVELNLASS CFQRTAIAFV NLLFLCIFYL FLIASCVSTH
60 70 80 90 100
FIVRGRKKGW IFVAVAICCA ITSFIFLGVG LNSLIHGGND VTEISWVACF
110 120 130 140 150
VEGIIWVSLA VSLLVNGSKW VNILVSVWWV SFALLDLVAK SGILLQGNGI
160 170 180 190 200
RILDILTLPM SLLLLLCSWM NLRSSSAAAQ DCSVTGLSDP LLTKNPRKES
210 220 230 240 250
ARLATAGFFS ILSFSWMNPL LSLGFKKPLS PEDIPSVVPE DEAQLAYKKF
260 270 280 290 300
SQAWDTLLGD ESSTKERNLV FRAVVKVYFK ENIFIAVFAF LRTFAVVSLP
310 320 330 340 350
LMLYVFVDYA NSDHRDLRNG FFNLACLVML KLVESLTMRH WYFASRRSGM
360 370 380 390 400
RIRSALMVAA YKKQLKLSSL GRKRHSSGEI VNYIAVDAYR MGEFLWWFHS
410 420 430 440 450
GWSLSLQLLL STAVLFGVVG AGAFPGLILL LLCGLLNLPF AKMLQNCQTQ
460 470 480 490 500
FMIAQDKRLR STSEILNSMK VIKLQSWEDE FKKKIESCRD DEFTWLAKAQ
510 520 530 540 550
LTKAFGSFLY WMSPTIVSSV VFLGCALLKS APLNASTIFT VLATLRVMSE
560 570 580 590 600
PVKIIPDAIS AIIQGNVSFQ RLNNFLLDDE LKMDEIERSG LDASGTAVDI
610 620 630 640 650
QVGNFGWEPE TKIPTLRNIH LEIKHGQKVA VCGPVGAGKS SLLHAVLGEI
660 670 680 690 700
PKVSGTVKVF GSIAYVSQTS WIQSGTIRDN ILYGKPMESR RYNAAIKACA
710 720 730 740 750
LDKDMNGFGH GDLTEIGQRG INLSGGQKQR IQLARAVYAD ADVYLLDDPF
760 770 780 790 800
SAVDAHTAGV LFHKCVEDSL KEKTVILVTH QVEFLSEVDQ ILVMEEGTIT
810 820 830 840 850
QSGKYEELLM MGTAFQQLVN AHNDAVTVLP LASNESLGDL RKEGKDREIR
860 870 880 890 900
NMTVVEKIEE EIEKTDIPGV QLTQEEEKES GYVGMKPFLD YIGVSRGWCL
910 920 930 940 950
LWSSVLGQVG FVVFQAASTY WLAFAIGIPK ITNTMLIGVY SIISTLSAGF
960 970 980 990 1000
VYARAITTAH LGLKASKAFF SGFTNAVFKA PMLFFDSTPV GRILTRASSD
1010 1020 1030 1040 1050
LNVLDYDVPF AFIFVVAPAV ELTAALLIMT YVTWQVIIIA LLALAATKVV
1060 1070 1080 1090 1100
QDYYLASARE LIRINGTTKA PVMNYAAETS LGVVTIRAFG TAERFFKNYL
1110 1120 1130 1140 1150
NLVDADAVLF FLSNAAMEWV ILRIETLQNV TLFTCALLLI LIPKGYIAPG
1160 1170 1180 1190 1200
LVGLSLSYAL TLTQTQVFLT RWYCTLSNSI ISVERIKQYM NIPEEPPAII
1210 1220 1230 1240 1250
DDKRPPSSWP SNGTIHLQEL KIRYRPNAPL VLKGISCTFR EGTRVGVVGR
1260 1270 1280 1290 1300
TGSGKSTLIS ALFRLVEPAS GCILIDGIDI SKIGLKDLRM KLSIIPQEPT
1310 1320 1330 1340 1350
LFRGCIRTNL DPLGVYSDDE IWKALEKCQL KTTISNLPNK LDSSVSDEGE
1360 1370 1380 1390 1400
NWSVGQRQLF CLGRVLLKRN KILVLDEATA SIDSATDAII QRIIREEFAD
1410 1420 1430 1440 1450
CTVITVAHRV PTVIDSDMVM VLSFGDLVEY NEPSKLMETD SYFSKLVAEY
1460
WASCRGNSSQ NLQL
Note: Constructed according to the conserved gene model. No experimental confirmation available.
Length:1,464
Mass (Da):162,072
Last modified:May 31, 2011 - v3
Checksum:iE446F0F714FB4BDB
GO
Isoform 2 (identifier: Q8LGU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     782-792: Missing.

Show »
Length:1,453
Mass (Da):160,799
Checksum:iEEEF1D316D0353A4
GO

Sequence cautioni

The sequence BAB01717 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD44995 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350M → L in CAD44995 (PubMed:12430019).Curated1
Sequence conflicti1301L → F in CAD44995 (PubMed:12430019).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041303782 – 792Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023045 Genomic DNA Translation: BAB01717.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE76481.1
CP002686 Genomic DNA Translation: AEE76482.1
AJ507057 mRNA Translation: CAD44995.1 Different initiation.
RefSeqiNP_001189944.1, NM_001203015.2 [Q8LGU1-1]
NP_188762.3, NM_113020.3 [Q8LGU1-2]
UniGeneiAt.38092

Genome annotation databases

EnsemblPlantsiAT3G21250.1; AT3G21250.1; AT3G21250 [Q8LGU1-2]
AT3G21250.2; AT3G21250.2; AT3G21250 [Q8LGU1-1]
GeneIDi821679
GrameneiAT3G21250.1; AT3G21250.1; AT3G21250 [Q8LGU1-2]
AT3G21250.2; AT3G21250.2; AT3G21250 [Q8LGU1-1]
KEGGiath:AT3G21250

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAB8C_ARATH
AccessioniPrimary (citable) accession number: Q8LGU1
Secondary accession number(s): Q9LU34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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