Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial

Gene

IDH6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs an essential role in the oxidative function of the citric acid cycle.By similarity

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127SubstrateBy similarity1
Binding sitei137SubstrateBy similarity1
Binding sitei158SubstrateBy similarity1
Sitei165Critical for catalysisBy similarity1
Sitei212Critical for catalysisBy similarity1
Metal bindingi245Magnesium or manganeseBy similarity1
Binding sitei245SubstrateBy similarity1
Metal bindingi269Magnesium or manganeseBy similarity1
Metal bindingi273Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • isocitrate dehydrogenase (NAD+) activity Source: TAIR
  • magnesium ion binding Source: InterPro
  • NAD binding Source: InterPro

GO - Biological processi

  • isocitrate metabolic process Source: TAIR
  • tricarboxylic acid cycle Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NAD

Enzyme and pathway databases

BRENDAi1.1.1.41 399
ReactomeiR-ATH-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial (EC:1.1.1.41)
Alternative name(s):
IDH-VI
Isocitric dehydrogenase 6
NAD(+)-specific ICDH 6
Gene namesi
Name:IDH6
Ordered Locus Names:At3g09810
ORF Names:F8A24.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09810
TAIRilocus:2074939 AT3G09810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_000027129245 – 374Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrialAdd BLAST330

Proteomic databases

PaxDbiQ8LG77
PRIDEiQ8LG77

Expressioni

Tissue specificityi

Ubiquitous. Predominantly expressed in leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ8LG77 baseline and differential
GenevisibleiQ8LG77 AT

Interactioni

Subunit structurei

Heterooligomer of catalytic and regulatory subunits.

Protein-protein interaction databases

STRINGi3702.AT3G09810.1

Structurei

3D structure databases

ProteinModelPortaliQ8LG77
SMRiQ8LG77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0785 Eukaryota
COG0473 LUCA
HOGENOMiHOG000021113
InParanoidiQ8LG77
KOiK00030
OMAiFRQNTEG
OrthoDBiEOG09360ECW
PhylomeDBiQ8LG77

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004434 Isocitrate_DH_NAD
IPR024084 IsoPropMal-DH-like_dom
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00175 mito_nad_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LG77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTAFLARR LIGNGSSQIL GTSSSSSGPF ISVSRAFFSS STPIKATLFP
60 70 80 90 100
GDGIGPEIAE SVKQVFTAAD VVIDWDEQFV GTEVDPRTNS FLTWDNLQSV
110 120 130 140 150
LKNKVGLKGP MATPIGKGHR SLNLTLRKEL NLYANVRPCY SLPGYKTRYD
160 170 180 190 200
DVDLITIREN TEGEYSGLEH QVVKGVVESL KIITRKASMR VAEYAFLYAK
210 220 230 240 250
THGRKKVSAI HKANIMQKTD GLFLQCCDEV AAKYPEIYYE KVVIDNCCMM
260 270 280 290 300
LVKNPALFDV LVMPNLYGDI ISDLCAGLVG GLGLTPSMNI GEDGIALAEA
310 320 330 340 350
VHGSAPDIAG MNLANPTALL LSGVMMLRHL KLNKQAEQIH SAIINTIAEG
360 370
KYRTADLGGS STTTDFTKAI CDHL
Length:374
Mass (Da):40,576
Last modified:January 9, 2007 - v2
Checksum:i3587127E0EAB87A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → I in AAM60999 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015985 Genomic DNA Translation: AAF23254.1
CP002686 Genomic DNA Translation: AEE74815.1
AF324664 mRNA Translation: AAG40015.1
AF327427 mRNA Translation: AAG42017.1
AF339723 mRNA Translation: AAK00405.1
AK176269 mRNA Translation: BAD44032.1
AK228113 mRNA Translation: BAF00071.1
AY084425 mRNA Translation: AAM60999.1
RefSeqiNP_850549.1, NM_180218.2
UniGeneiAt.22515

Genome annotation databases

EnsemblPlantsiAT3G09810.1; AT3G09810.1; AT3G09810
GeneIDi820139
GrameneiAT3G09810.1; AT3G09810.1; AT3G09810
KEGGiath:AT3G09810

Similar proteinsi

Entry informationi

Entry nameiIDH6_ARATH
AccessioniPrimary (citable) accession number: Q8LG77
Secondary accession number(s): Q9SF84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health