Reviewed, UniProtKB/Swiss-Prot Q8LG70 (6PGL2_ARATH)

Names and origin

Protein names

Recommended name:
    Probable 6-phosphogluconolactonase 2
      Short name=6PGL 2
    EC=3.1.1.31

Gene names

Ordered Locus Names:	At3g49360
ORF Names:	F2K15.220, T1G12.6

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from direct assay. Source: TAIR
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Probable 6-phosphogluconolactonase 2		PRO_0000288669
Experimental info
	Sequence conflict	35	1	G → E in AAM61007. Ref.3
	Sequence conflict	42	1	S → Y in AAM61007. Ref.3
	Sequence conflict	99	1	V → I in AAM61007. Ref.3
	Sequence conflict	108	1	D → N in AAM61007. Ref.3
	Sequence conflict	194	1	L → F in AAM61007. Ref.3
	Sequence conflict	218	1	V → A in AAM61007. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8LG70-1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: DA9C421E48BC0CA6	FASTA	259	28,863
	10 20 30 40 50 60 MAPVKRRVFK TNNEMAVELA KYTADLSSKF CKERGVFTVV LSGGDLIAWL WKLLEAPYID 70 80 90 100 110 120 SIEWSKWHIF WVDERVCAWD HADSNYKLAY DGFLSKVPVP AENIYAIDNG LGAEGNAELA 130 140 150 160 170 180 AERYEECLKQ KVNQNIIRTY KSSGFPQFDL QLLGMGPDGH MASLFPGHAQ INEKVKWVTS 190 200 210 220 230 240 ITDSPKPPSK RITLTLPVIN CASYNVMAVC DKEQADSVAA ALNHTKDLPA GRLTADVEVV 250 WFLDQAAASK LPHGWCSIL

References

[1]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Arabidopsis ORF clones." Shinn P., Chen H., Kim C.J., Ecker J.R. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012329 Genomic DNA. Translation: AAG52194.1. AL132956 Genomic DNA. Translation: CAB66415.1. AK117146 mRNA. Translation: BAC41824.1. AY084434 mRNA. Translation: AAM61007.1. BT024902 mRNA. Translation: ABD91493.1.
IPI	IPI00526858.
PIR	T45841.
RefSeq	NP_190505.1.
UniGene	At.43224
3D structure databases
SMR	Q8LG70. Positions 5-251.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8LG70.
Proteomic databases
PRIDE	Q8LG70.
Genome annotation databases
GeneID	824098.
GenomeReviews	Gene locus AT3G49360 in contig BA000014_GR.
KEGG	ath:AT3G49360.
NMPDR	fig|3702.1.peg.16183.
Organism-specific databases
TAIR	At3g49360.
Phylogenomic databases
eggNOG	KOG3147.
HOGENOM	HBG725991.
InParanoid	Q8LG70.
OMA	EEYSATI.
PhylomeDB	Q8LG70.
Enzyme and pathway databases
BRENDA	3.1.1.31. 302.
Gene expression databases
Genevestigator	Q8LG70.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
PANTHER	PTHR11054. Phosphogluconlac. 1 hit.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL2_ARATH

Accession

Primary (citable) accession number: Q8LG70
Secondary accession number(s): Q9SG13

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	February 9, 2010
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)