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Protein

Probable 6-phosphogluconolactonase 2

Gene

At3g49360

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway:ipentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 2 (At3g49360), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700)
  3. 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciARA:AT3G49360-MONOMER.
BRENDAi3.1.1.31. 399.
ReactomeiREACT_281719. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 2 (EC:3.1.1.31)
Short name:
6PGL 2
Gene namesi
Ordered Locus Names:At3g49360
ORF Names:F2K15.220, T1G12.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G49360.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Probable 6-phosphogluconolactonase 2PRO_0000288669Add
BLAST

Proteomic databases

PaxDbiQ8LG70.
PRIDEiQ8LG70.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G49360.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LG70.
SMRiQ8LG70. Positions 3-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256285.
InParanoidiQ8LG70.
KOiK01057.
OMAiNCASYNV.
PhylomeDBiQ8LG70.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8LG70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVKRRVFK TNNEMAVELA KYTADLSSKF CKERGVFTVV LSGGDLIAWL
60 70 80 90 100
WKLLEAPYID SIEWSKWHIF WVDERVCAWD HADSNYKLAY DGFLSKVPVP
110 120 130 140 150
AENIYAIDNG LGAEGNAELA AERYEECLKQ KVNQNIIRTY KSSGFPQFDL
160 170 180 190 200
QLLGMGPDGH MASLFPGHAQ INEKVKWVTS ITDSPKPPSK RITLTLPVIN
210 220 230 240 250
CASYNVMAVC DKEQADSVAA ALNHTKDLPA GRLTADVEVV WFLDQAAASK

LPHGWCSIL
Length:259
Mass (Da):28,863
Last modified:May 29, 2007 - v2
Checksum:iDA9C421E48BC0CA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351G → E in AAM61007 (Ref. 4) Curated
Sequence conflicti42 – 421S → Y in AAM61007 (Ref. 4) Curated
Sequence conflicti99 – 991V → I in AAM61007 (Ref. 4) Curated
Sequence conflicti108 – 1081D → N in AAM61007 (Ref. 4) Curated
Sequence conflicti194 – 1941L → F in AAM61007 (Ref. 4) Curated
Sequence conflicti218 – 2181V → A in AAM61007 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012329 Genomic DNA. Translation: AAG52194.1.
AL132956 Genomic DNA. Translation: CAB66415.1.
CP002686 Genomic DNA. Translation: AEE78532.1.
AK117146 mRNA. Translation: BAC41824.1.
AY084434 mRNA. Translation: AAM61007.1.
BT024902 mRNA. Translation: ABD91493.1.
PIRiT45841.
RefSeqiNP_190505.1. NM_114796.3.
UniGeneiAt.43224.

Genome annotation databases

EnsemblPlantsiAT3G49360.1; AT3G49360.1; AT3G49360.
GeneIDi824098.
KEGGiath:AT3G49360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012329 Genomic DNA. Translation: AAG52194.1.
AL132956 Genomic DNA. Translation: CAB66415.1.
CP002686 Genomic DNA. Translation: AEE78532.1.
AK117146 mRNA. Translation: BAC41824.1.
AY084434 mRNA. Translation: AAM61007.1.
BT024902 mRNA. Translation: ABD91493.1.
PIRiT45841.
RefSeqiNP_190505.1. NM_114796.3.
UniGeneiAt.43224.

3D structure databases

ProteinModelPortaliQ8LG70.
SMRiQ8LG70. Positions 3-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G49360.1.

Proteomic databases

PaxDbiQ8LG70.
PRIDEiQ8LG70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G49360.1; AT3G49360.1; AT3G49360.
GeneIDi824098.
KEGGiath:AT3G49360.

Organism-specific databases

TAIRiAT3G49360.

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256285.
InParanoidiQ8LG70.
KOiK01057.
OMAiNCASYNV.
PhylomeDBiQ8LG70.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciARA:AT3G49360-MONOMER.
BRENDAi3.1.1.31. 399.
ReactomeiREACT_281719. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiQ8LG70.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Arabidopsis ORF clones."
    Shinn P., Chen H., Kim C.J., Ecker J.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry namei6PGL2_ARATH
AccessioniPrimary (citable) accession number: Q8LG70
Secondary accession number(s): Q9SG13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.