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Protein

Probable 6-phosphogluconolactonase 2

Gene

At3g49360

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciARA:AT3G49360-MONOMER
BRENDAi3.1.1.31 399
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 2 (EC:3.1.1.31)
Short name:
6PGL 2
Gene namesi
Ordered Locus Names:At3g49360
ORF Names:F2K15.220, T1G12.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G49360
TAIRilocus:2082916 AT3G49360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886691 – 259Probable 6-phosphogluconolactonase 2Add BLAST259

Proteomic databases

PaxDbiQ8LG70

Expressioni

Gene expression databases

ExpressionAtlasiQ8LG70 baseline and differential
GenevisibleiQ8LG70 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G49360.1

Structurei

3D structure databases

ProteinModelPortaliQ8LG70
SMRiQ8LG70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
HOGENOMiHOG000256285
InParanoidiQ8LG70
KOiK01057
OMAiERVCAWD
OrthoDBiEOG09360PR9
PhylomeDBiQ8LG70

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LG70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVKRRVFK TNNEMAVELA KYTADLSSKF CKERGVFTVV LSGGDLIAWL
60 70 80 90 100
WKLLEAPYID SIEWSKWHIF WVDERVCAWD HADSNYKLAY DGFLSKVPVP
110 120 130 140 150
AENIYAIDNG LGAEGNAELA AERYEECLKQ KVNQNIIRTY KSSGFPQFDL
160 170 180 190 200
QLLGMGPDGH MASLFPGHAQ INEKVKWVTS ITDSPKPPSK RITLTLPVIN
210 220 230 240 250
CASYNVMAVC DKEQADSVAA ALNHTKDLPA GRLTADVEVV WFLDQAAASK

LPHGWCSIL
Length:259
Mass (Da):28,863
Last modified:May 29, 2007 - v2
Checksum:iDA9C421E48BC0CA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → E in AAM61007 (Ref. 4) Curated1
Sequence conflicti42S → Y in AAM61007 (Ref. 4) Curated1
Sequence conflicti99V → I in AAM61007 (Ref. 4) Curated1
Sequence conflicti108D → N in AAM61007 (Ref. 4) Curated1
Sequence conflicti194L → F in AAM61007 (Ref. 4) Curated1
Sequence conflicti218V → A in AAM61007 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012329 Genomic DNA Translation: AAG52194.1
AL132956 Genomic DNA Translation: CAB66415.1
CP002686 Genomic DNA Translation: AEE78532.1
AK117146 mRNA Translation: BAC41824.1
AY084434 mRNA Translation: AAM61007.1
BT024902 mRNA Translation: ABD91493.1
PIRiT45841
RefSeqiNP_190505.1, NM_114796.4
UniGeneiAt.43224

Genome annotation databases

EnsemblPlantsiAT3G49360.1; AT3G49360.1; AT3G49360
GeneIDi824098
GrameneiAT3G49360.1; AT3G49360.1; AT3G49360
KEGGiath:AT3G49360

Similar proteinsi

Entry informationi

Entry namei6PGL2_ARATH
AccessioniPrimary (citable) accession number: Q8LG70
Secondary accession number(s): Q9SG13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health