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Protein

Cyclin-dependent kinase B2-2

Gene

CDKB2-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: GO_Central
  • hormone-mediated signaling pathway Source: TAIR
  • multicellular organism development Source: GO_Central
  • positive regulation of cell proliferation Source: GO_Central
  • protein autophosphorylation Source: TAIR
  • regulation of G2/M transition of mitotic cell cycle Source: TAIR
  • regulation of gene expression Source: GO_Central
  • regulation of meristem structural organization Source: TAIR
  • regulation of mitotic cell cycle Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase B2-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKB2;2
Gene namesi
Name:CDKB2-2
Ordered Locus Names:At1g20930
ORF Names:F9H16.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G20930
TAIRilocus:2037410 AT1G20930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931161 – 315Cyclin-dependent kinase B2-2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphotyrosineBy similarity1
Modified residuei181PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8LG64

Expressioni

Tissue specificityi

Expressed in flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ8LG64 baseline and differential
GenevisibleiQ8LG64 AT

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi23926, 19 interactors
IntActiQ8LG64, 16 interactors
STRINGi3702.AT1G20930.1

Structurei

3D structure databases

ProteinModelPortaliQ8LG64
SMRiQ8LG64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
HOGENOMiHOG000233024
InParanoidiQ8LG64
KOiK07760
OMAiPSTCLRE
OrthoDBiEOG09360F64
PhylomeDBiQ8LG64

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LG64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNGVKPAV SAMEAFEKLE KVGEGTYGKV YRAREKATGM IVALKKTRLH
60 70 80 90 100
EDEEGVPPTT LREISILRML ARDPHIVRLM DVKQGINKEG KTVLYLVFEY
110 120 130 140 150
VDTDLKKFIR SFRQAGQNIP QNTVKCLMYQ LCKGMAFCHG HGVLHRDLKP
160 170 180 190 200
HNLLMDRKTM TLKIADLGLA RAFTLPMKKY THEILTLWYR APEVLLGATH
210 220 230 240 250
YSTGVDMWSV GCIFAELVTK QAIFAGDSEL QQLLRIFRLL GTPNEEVWPG
260 270 280 290 300
VSKLKDWHEY PQWKPLSLST AVPNLDEAGL DLLSKMLEYE PAKRISAKKA
310
MEHPYFDDLP DKSSL
Length:315
Mass (Da):35,847
Last modified:July 10, 2007 - v2
Checksum:i3C1A33C9FD94F36F
GO

Sequence cautioni

The sequence AAM61014 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007369 Genomic DNA Translation: AAD30597.1
CP002684 Genomic DNA Translation: AEE30043.1
BT024780 mRNA Translation: ABD59118.1
AK229456 mRNA Translation: BAF01314.1
AY084441 mRNA Translation: AAM61014.1 Different initiation.
PIRiB86342
RefSeqiNP_173517.1, NM_101946.4
UniGeneiAt.20756
At.41679

Genome annotation databases

EnsemblPlantsiAT1G20930.1; AT1G20930.1; AT1G20930
GeneIDi838687
GrameneiAT1G20930.1; AT1G20930.1; AT1G20930
KEGGiath:AT1G20930

Similar proteinsi

Entry informationi

Entry nameiCKB22_ARATH
AccessioniPrimary (citable) accession number: Q8LG64
Secondary accession number(s): Q9SYP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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