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Protein

Aquaporin NIP1-2

Gene

NIP1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Water channel probably required to promote glycerol permeability and water transport across cell membranes.1 Publication

GO - Molecular functioni

  • arsenite transmembrane transporter activity Source: TAIR
  • water channel activity Source: GO_Central

GO - Biological processi

  • arsenite transport Source: TAIR
  • hydrogen peroxide transmembrane transport Source: TAIR
  • response to arsenic-containing substance Source: TAIR

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi1.A.8.12.7 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin NIP1-2
Alternative name(s):
NOD26-like intrinsic protein 1-2
Short name:
AtNIP1;2
Nodulin-26-like major intrinsic protein 2
Short name:
NodLikeMip2
Short name:
Protein NLM2
Gene namesi
Name:NIP1-2
Synonyms:NLM2
Ordered Locus Names:At4g18910
ORF Names:F13C5.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G18910
TAIRilocus:2117184 AT4G18910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 74Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei177 – 197Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640631 – 294Aquaporin NIP1-2Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8LFP7

PTM databases

iPTMnetiQ8LFP7

Expressioni

Tissue specificityi

Expressed in developing seeds.1 Publication

Gene expression databases

ExpressionAtlasiQ8LFP7 baseline and differential
GenevisibleiQ8LFP7 AT

Interactioni

Protein-protein interaction databases

BioGridi12919, 1 interactor
STRINGi3702.AT4G18910.1

Structurei

3D structure databases

ProteinModelPortaliQ8LFP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 113NPA 13
Motifi230 – 232NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 31Poly-Gln6

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Gly (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
HOGENOMiHOG000288286
InParanoidiQ8LFP7
KOiK09874
OMAiQVVATMF
OrthoDBiEOG09360N7X
PhylomeDBiQ8LFP7

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LFP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEISGNGGD ARDGAVVVNL KEEDEQQQQQ QAIHKPLKKQ DSLLSISVPF
60 70 80 90 100
LQKLMAEVLG TYFLIFAGCA AVAVNTQHDK AVTLPGIAIV WGLTVMVLVY
110 120 130 140 150
SLGHISGAHF NPAVTIAFAS CGRFPLKQVP AYVISQVIGS TLAAATLRLL
160 170 180 190 200
FGLDQDVCSG KHDVFVGTLP SGSNLQSFVI EFIITFYLMF VISGVATDNR
210 220 230 240 250
AIGELAGLAV GSTVLLNVII AGPVSGASMN PGRSLGPAMV YSCYRGLWIY
260 270 280 290
IVSPIVGAVS GAWVYNMVRY TDKPLREITK SGSFLKTVRN GSSR
Length:294
Mass (Da):31,269
Last modified:June 27, 2003 - v2
Checksum:iAF337613903285C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Missing in AAM61294 (Ref. 5) Curated1
Sequence conflicti85P → L in AAM61294 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250668 mRNA Translation: CAC14597.1
AL021711 Genomic DNA Translation: CAA16748.1
AL161549 Genomic DNA Translation: CAB78893.1
CP002687 Genomic DNA Translation: AEE84106.1
AY072380 mRNA Translation: AAL62372.1
BT000096 mRNA Translation: AAN15415.1
AY084720 mRNA Translation: AAM61294.1
PIRiT05028
RefSeqiNP_193626.1, NM_118008.4
UniGeneiAt.1953

Genome annotation databases

EnsemblPlantsiAT4G18910.1; AT4G18910.1; AT4G18910
GeneIDi827626
GrameneiAT4G18910.1; AT4G18910.1; AT4G18910
KEGGiath:AT4G18910

Similar proteinsi

Entry informationi

Entry nameiNIP12_ARATH
AccessioniPrimary (citable) accession number: Q8LFP7
Secondary accession number(s): O49406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 27, 2003
Last modified: April 25, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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