ID   6PGL5_ARATH             Reviewed;         252 AA.
AC   Q8LEV7; Q9FIN0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   24-JAN-2024, entry version 115.
DE   RecName: Full=Probable 6-phosphogluconolactonase 5 {ECO:0000305};
DE            Short=6PGL5 {ECO:0000305};
DE            EC=3.1.1.31 {ECO:0000250|UniProtKB:Q84WW2};
GN   Name=PGL5 {ECO:0000303|PubMed:19457984};
GN   OrderedLocusNames=At5g24420 {ECO:0000312|Araport:AT5G24420};
GN   ORFNames=K16H17.13 {ECO:0000312|EMBL:BAB11235.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA   Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT   features of the regions of 1,081,958 bp covered by seventeen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:379-391(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX   PubMed=19457984; DOI=10.1093/pcp/pcp070;
RA   Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.;
RT   "Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion
RT   mutants reveals an essential role for the oxidative section of the
RT   plastidic pentose phosphate pathway in plant growth and development.";
RL   Plant Cell Physiol. 50:1277-1291(2009).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=24008768; DOI=10.1093/mp/sst126;
RA   Hoelscher C., Meyer T., von Schaewen A.;
RT   "Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to
RT   chloroplasts and peroxisomes involves interaction with Trx m2 in the
RT   cytosol.";
RL   Mol. Plant 7:252-255(2014).
CC   -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC       phosphogluconate. {ECO:0000250|UniProtKB:Q84WW2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000250|UniProtKB:Q84WW2};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:19457984}.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR   EMBL; AB016884; BAB11235.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED93309.1; -; Genomic_DNA.
DR   EMBL; AF378879; AAK55682.1; -; mRNA.
DR   EMBL; AY052737; AAK96451.1; -; mRNA.
DR   EMBL; AY085203; AAM61753.1; -; mRNA.
DR   RefSeq; NP_197830.1; NM_122350.4.
DR   AlphaFoldDB; Q8LEV7; -.
DR   SMR; Q8LEV7; -.
DR   STRING; 3702.Q8LEV7; -.
DR   MetOSite; Q8LEV7; -.
DR   PaxDb; 3702-AT5G24420-1; -.
DR   ProteomicsDB; 244623; -.
DR   EnsemblPlants; AT5G24420.1; AT5G24420.1; AT5G24420.
DR   GeneID; 832513; -.
DR   Gramene; AT5G24420.1; AT5G24420.1; AT5G24420.
DR   KEGG; ath:AT5G24420; -.
DR   Araport; AT5G24420; -.
DR   TAIR; AT5G24420; PGL5.
DR   eggNOG; KOG3147; Eukaryota.
DR   HOGENOM; CLU_053947_0_0_1; -.
DR   InParanoid; Q8LEV7; -.
DR   OMA; VENVWYL; -.
DR   OrthoDB; 296373at2759; -.
DR   PhylomeDB; Q8LEV7; -.
DR   BioCyc; ARA:AT5G24420-MONOMER; -.
DR   BRENDA; 3.1.1.31; 399.
DR   UniPathway; UPA00115; UER00409.
DR   PRO; PR:Q8LEV7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8LEV7; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   Gene3D; 3.40.50.1360; -; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   NCBIfam; TIGR01198; pgl; 1.
DR   PANTHER; PTHR11054; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   PANTHER; PTHR11054:SF16; 6-PHOSPHOGLUCONOLACTONASE 5-RELATED; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR   Genevisible; Q8LEV7; AT.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Probable 6-phosphogluconolactonase 5"
FT                   /id="PRO_0000288670"
FT   CONFLICT        65
FT                   /note="P -> S (in Ref. 4; AAM61753)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   252 AA;  28476 MW;  FAFEECE1F712FDA1 CRC64;
     MAQRKMIVFP TKNELSEAMA EYTANLSAKF IKEKGLFTVV LSGGDLIDWL CKLVQPPYID
     SIEWPKWHVF WVDERVCAWE DPDSNYKLAM EGFLSKVPIP DKNIYAIDKH LAADGNAEHC
     ATLYEECLKN LVKEKIIPIS KKTGYPEFDL QLLGMGPDGH MASLFPNHPQ INEKQKWVTY
     ITDSPKPPPK RITFTLPVIN STLYNLMAIC DKAPAKSVAE IMKHNNLSLP SAHLSAQVEN
     VWYLDQAAAS EL
//