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Protein

Probable 6-phosphogluconolactonase 3

Gene

At5g24420

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciARA:AT5G24420-MONOMER
BRENDAi3.1.1.31 399
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 3 (EC:3.1.1.31)
Short name:
6PGL 3
Gene namesi
Ordered Locus Names:At5g24420
ORF Names:K16H17.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G24420
TAIRilocus:2152916 AT5G24420

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886701 – 252Probable 6-phosphogluconolactonase 3Add BLAST252

Proteomic databases

PaxDbiQ8LEV7

Expressioni

Gene expression databases

ExpressionAtlasiQ8LEV7 baseline and differential
GenevisibleiQ8LEV7 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G24420.1

Structurei

3D structure databases

ProteinModelPortaliQ8LEV7
SMRiQ8LEV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
HOGENOMiHOG000256285
InParanoidiQ8LEV7
KOiK01057
OMAiERVCAWE
OrthoDBiEOG09360PR9
PhylomeDBiQ8LEV7

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LEV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRKMIVFP TKNELSEAMA EYTANLSAKF IKEKGLFTVV LSGGDLIDWL
60 70 80 90 100
CKLVQPPYID SIEWPKWHVF WVDERVCAWE DPDSNYKLAM EGFLSKVPIP
110 120 130 140 150
DKNIYAIDKH LAADGNAEHC ATLYEECLKN LVKEKIIPIS KKTGYPEFDL
160 170 180 190 200
QLLGMGPDGH MASLFPNHPQ INEKQKWVTY ITDSPKPPPK RITFTLPVIN
210 220 230 240 250
STLYNLMAIC DKAPAKSVAE IMKHNNLSLP SAHLSAQVEN VWYLDQAAAS

EL
Length:252
Mass (Da):28,476
Last modified:May 29, 2007 - v2
Checksum:iFAFEECE1F712FDA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65P → S in AAM61753 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016884 Genomic DNA Translation: BAB11235.1
CP002688 Genomic DNA Translation: AED93309.1
AF378879 mRNA Translation: AAK55682.1
AY052737 mRNA Translation: AAK96451.1
AY085203 mRNA Translation: AAM61753.1
RefSeqiNP_197830.1, NM_122350.4
UniGeneiAt.8628

Genome annotation databases

EnsemblPlantsiAT5G24420.1; AT5G24420.1; AT5G24420
GeneIDi832513
GrameneiAT5G24420.1; AT5G24420.1; AT5G24420
KEGGiath:AT5G24420

Similar proteinsi

Entry informationi

Entry namei6PGL3_ARATH
AccessioniPrimary (citable) accession number: Q8LEV7
Secondary accession number(s): Q9FIN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health