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Protein

Thioredoxin-like protein CXXS1

Gene

CXXS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein CXXS1
Short name:
AtCXXS1
Alternative name(s):
Mono-cysteine thioredoxin 1
Gene namesi
Name:CXXS1
Ordered Locus Names:At1g11530
ORF Names:T23J18.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRilocus:2200141. AT1G11530.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200651 – 118Thioredoxin-like protein CXXS1Add BLAST118

Proteomic databases

PaxDbiQ8LDI5.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ8LDI5. baseline and differential.
GenevisibleiQ8LDI5. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G11530.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LDI5.
SMRiQ8LDI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 110ThioredoxinPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ8LDI5.
KOiK03671.
OMAiCPIVAHF.
OrthoDBiEOG09360T0P.
PhylomeDBiQ8LDI5.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8LDI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVVKIDSA ESWNFYVSQA KNQNCPIVAH FTALWCIPSV FMNSFFEELA
60 70 80 90 100
FNYKDALFLI VDVDEVKEVA SQLEVKAMPT FLFLKDGNAM DKLVGANPDE
110
IKKRVDGFVQ SSRVVHIA
Length:118
Mass (Da):13,334
Last modified:August 31, 2004 - v2
Checksum:i2D6994B3F03B039A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14N → D in AAM63200 (Ref. 5) Curated1
Sequence conflicti86D → G in AAD37583 (PubMed:10498962).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144390 mRNA. Translation: AAD35008.1.
AF144392 Genomic DNA. Translation: AAD37583.1.
AC011661 Genomic DNA. Translation: AAF16634.1.
CP002684 Genomic DNA. Translation: AEE28748.1.
BT024568 mRNA. Translation: ABD38907.1.
AY085990 mRNA. Translation: AAM63200.1.
PIRiF86248.
RefSeqiNP_172620.1. NM_101026.3.
UniGeneiAt.11326.
At.63949.

Genome annotation databases

EnsemblPlantsiAT1G11530.1; AT1G11530.1; AT1G11530.
GeneIDi837696.
GrameneiAT1G11530.1; AT1G11530.1; AT1G11530.
KEGGiath:AT1G11530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144390 mRNA. Translation: AAD35008.1.
AF144392 Genomic DNA. Translation: AAD37583.1.
AC011661 Genomic DNA. Translation: AAF16634.1.
CP002684 Genomic DNA. Translation: AEE28748.1.
BT024568 mRNA. Translation: ABD38907.1.
AY085990 mRNA. Translation: AAM63200.1.
PIRiF86248.
RefSeqiNP_172620.1. NM_101026.3.
UniGeneiAt.11326.
At.63949.

3D structure databases

ProteinModelPortaliQ8LDI5.
SMRiQ8LDI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G11530.1.

Proteomic databases

PaxDbiQ8LDI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G11530.1; AT1G11530.1; AT1G11530.
GeneIDi837696.
GrameneiAT1G11530.1; AT1G11530.1; AT1G11530.
KEGGiath:AT1G11530.

Organism-specific databases

AraportiAT1G11530.
TAIRilocus:2200141. AT1G11530.

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiQ8LDI5.
KOiK03671.
OMAiCPIVAHF.
OrthoDBiEOG09360T0P.
PhylomeDBiQ8LDI5.

Miscellaneous databases

PROiPR:Q8LDI5.

Gene expression databases

ExpressionAtlasiQ8LDI5. baseline and differential.
GenevisibleiQ8LDI5. AT.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXXS1_ARATH
AccessioniPrimary (citable) accession number: Q8LDI5
Secondary accession number(s): Q2HIL3, Q9SYX9, Q9XH49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 10, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved cysteine (here Ser-39), present in the redox-active center, which is one of the conserved features of the thioredoxin family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.