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Q8LBZ7

- SDHB1_ARATH

UniProt

Q8LBZ7 - SDHB1_ARATH

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial

Gene

SDH2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi107 – 1071Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi110 – 1101Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi122 – 1221Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi194 – 1941Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi197 – 1971Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi204 – 2041Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei209 – 2091Ubiquinone; shared with DHSDBy similarity
    Metal bindingi251 – 2511Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi257 – 2571Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi261 – 2611Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: TAIR
    5. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    6. succinate dehydrogenase activity Source: TAIR
    7. zinc ion binding Source: TAIR

    GO - Biological processi

    1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:GQT-2052-MONOMER.
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:SDH2-1
    Ordered Locus Names:At3g27380
    ORF Names:K1G2.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G27380.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: TAIR
    3. succinate dehydrogenase complex Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 279251Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrialPRO_0000247595Add
    BLAST

    Proteomic databases

    PaxDbiQ8LBZ7.
    PRIDEiQ8LBZ7.

    Expressioni

    Tissue specificityi

    Ubiquitous. Preferentially expressed in flowers and inflorescences.3 Publications

    Developmental stagei

    Expressed in floral meristems and sex organ primordia at early stages of development. Later expressed in anthers, particularly in the tapetum, pollen mother cells, and microspores.1 Publication

    Gene expression databases

    ArrayExpressiQ8LBZ7.
    GenevestigatoriQ8LBZ7.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    IntActiQ8LBZ7. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LBZ7.
    SMRiQ8LBZ7. Positions 47-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 141902Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini184 – 214314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    HOGENOMiHOG000160590.
    InParanoidiQ9LTZ2.
    KOiK00235.
    OMAiSEPHWES.
    PhylomeDBiQ8LBZ7.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8LBZ7-1 [UniParc]FASTAAdd to Basket

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    MASGLIGRLV GTKPSKLATA ARLIPARWTS TGAEAETKAS SGGGRGSNLK    50
    TFQIYRWNPD NPGKPELQNY QIDLKDCGPM VLDALIKIKN EMDPSLTFRR 100
    SCREGICGSC AMNIDGCNGL ACLTKIQDEA SETTITPLPH MFVIKDLVVD 150
    MTNFYNQYKS IEPWLKRKTP ASVPAKEILQ SKKDRAKLDG MYECILCACC 200
    STSCPSYWWN PESYLGPAAL LHANRWISDS RDEYTKERLE AIDDEFKLYR 250
    CHTILNCARA CPKGLNPGKQ ITHIKQLQR 279
    Length:279
    Mass (Da):31,171
    Last modified:July 25, 2006 - v2
    Checksum:iADA885EC59A3EA36
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201A → V in CAC19855. (PubMed:11442063)Curated
    Sequence conflicti20 – 201A → V in AAM63946. 1 PublicationCurated
    Sequence conflicti26 – 261A → V in CAC19855. (PubMed:11442063)Curated
    Sequence conflicti26 – 261A → V in AAM63946. 1 PublicationCurated
    Sequence conflicti200 – 2001C → F in AAM63946. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278910 mRNA. Translation: CAC19855.1.
    AB024028 Genomic DNA. Translation: BAA95713.1.
    CP002686 Genomic DNA. Translation: AEE77309.1.
    CP002686 Genomic DNA. Translation: AEE77310.1.
    AY035013 mRNA. Translation: AAK59518.1.
    AY063053 mRNA. Translation: AAL34227.1.
    AY924777 mRNA. Translation: AAX23852.1.
    AY086901 mRNA. Translation: AAM63946.1.
    RefSeqiNP_001118718.1. NM_001125246.1.
    NP_189374.1. NM_113653.3.
    UniGeneiAt.17610.
    At.22540.
    At.32384.
    At.71559.

    Genome annotation databases

    EnsemblPlantsiAT3G27380.1; AT3G27380.1; AT3G27380.
    AT3G27380.2; AT3G27380.2; AT3G27380.
    GeneIDi822359.
    KEGGiath:AT3G27380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278910 mRNA. Translation: CAC19855.1 .
    AB024028 Genomic DNA. Translation: BAA95713.1 .
    CP002686 Genomic DNA. Translation: AEE77309.1 .
    CP002686 Genomic DNA. Translation: AEE77310.1 .
    AY035013 mRNA. Translation: AAK59518.1 .
    AY063053 mRNA. Translation: AAL34227.1 .
    AY924777 mRNA. Translation: AAX23852.1 .
    AY086901 mRNA. Translation: AAM63946.1 .
    RefSeqi NP_001118718.1. NM_001125246.1.
    NP_189374.1. NM_113653.3.
    UniGenei At.17610.
    At.22540.
    At.32384.
    At.71559.

    3D structure databases

    ProteinModelPortali Q8LBZ7.
    SMRi Q8LBZ7. Positions 47-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8LBZ7. 2 interactions.

    Proteomic databases

    PaxDbi Q8LBZ7.
    PRIDEi Q8LBZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G27380.1 ; AT3G27380.1 ; AT3G27380 .
    AT3G27380.2 ; AT3G27380.2 ; AT3G27380 .
    GeneIDi 822359.
    KEGGi ath:AT3G27380.

    Organism-specific databases

    GeneFarmi 2168. 175.
    TAIRi AT3G27380.

    Phylogenomic databases

    eggNOGi COG0479.
    HOGENOMi HOG000160590.
    InParanoidi Q9LTZ2.
    KOi K00235.
    OMAi SEPHWES.
    PhylomeDBi Q8LBZ7.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    BioCyci ARA:GQT-2052-MONOMER.

    Gene expression databases

    ArrayExpressi Q8LBZ7.
    Genevestigatori Q8LBZ7.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three different genes encode the iron-sulphur subunit of succinate dehydrogenase in Arabidopsis thaliana."
      Figueroa P., Leon G., Elorza A., Holuigue L., Jordana X.
      Plant Mol. Biol. 46:241-250(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana."
      Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.
      Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY.
    8. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.
    9. "Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities."
      Elorza A., Leon G., Gomez I., Mouras A., Holuigue L., Araya A., Jordana X.
      Plant Physiol. 136:4072-4087(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSDHB1_ARATH
    AccessioniPrimary (citable) accession number: Q8LBZ7
    Secondary accession number(s): Q9G3M0, Q9LTZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3