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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial

Gene

SDH2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity
  • [3Fe-4S] clusterBy similarityNote: Binds 1 [3Fe-4S] cluster.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial (SDH1-1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At5g38380), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At3g29870), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial (SDH2-3), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (SDH2-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At2g13790), Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (SDH1-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (SDH2-2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At5g66760)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi107Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi122Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi194Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi197Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi200Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi204Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei209Ubiquinone; shared with SdhD subunitBy similarity1
Metal bindingi251Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi257Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi261Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  • 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • electron transfer activity Source: TAIR
  • succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  • succinate dehydrogenase activity Source: TAIR
  • zinc ion binding Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BRENDAi1.3.5.1 399
UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2-1
Ordered Locus Names:At3g27380
ORF Names:K1G2.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G27380
TAIRilocus:2086716 AT3G27380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000024759529 – 279Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrialAdd BLAST251

Proteomic databases

PaxDbiQ8LBZ7
PRIDEiQ8LBZ7

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in flowers and inflorescences.2 Publications

Developmental stagei

Expressed in floral meristems and sex organ primordia at early stages of development. Later expressed in anthers, particularly in the tapetum, pollen mother cells, and microspores.1 Publication

Gene expression databases

ExpressionAtlasiQ8LBZ7 baseline and differential
GenevisibleiQ8LBZ7 AT

Interactioni

Subunit structurei

Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.1 Publication

Protein-protein interaction databases

IntActiQ8LBZ7, 2 interactors
MINTiQ8LBZ7
STRINGi3702.AT3G27380.1

Structurei

3D structure databases

ProteinModelPortaliQ8LBZ7
SMRiQ8LBZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 1412Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST90
Domaini184 – 2144Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
HOGENOMiHOG000160590
InParanoidiQ8LBZ7
KOiK00235
OMAiDAMNINR
OrthoDBiEOG093609RV
PhylomeDBiQ8LBZ7

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LBZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGLIGRLV GTKPSKLATA ARLIPARWTS TGAEAETKAS SGGGRGSNLK
60 70 80 90 100
TFQIYRWNPD NPGKPELQNY QIDLKDCGPM VLDALIKIKN EMDPSLTFRR
110 120 130 140 150
SCREGICGSC AMNIDGCNGL ACLTKIQDEA SETTITPLPH MFVIKDLVVD
160 170 180 190 200
MTNFYNQYKS IEPWLKRKTP ASVPAKEILQ SKKDRAKLDG MYECILCACC
210 220 230 240 250
STSCPSYWWN PESYLGPAAL LHANRWISDS RDEYTKERLE AIDDEFKLYR
260 270
CHTILNCARA CPKGLNPGKQ ITHIKQLQR
Length:279
Mass (Da):31,171
Last modified:July 25, 2006 - v2
Checksum:iADA885EC59A3EA36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → V in CAC19855 (PubMed:11442063).Curated1
Sequence conflicti20A → V in AAM63946 (Ref. 6) Curated1
Sequence conflicti26A → V in CAC19855 (PubMed:11442063).Curated1
Sequence conflicti26A → V in AAM63946 (Ref. 6) Curated1
Sequence conflicti200C → F in AAM63946 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278910 mRNA Translation: CAC19855.1
AB024028 Genomic DNA Translation: BAA95713.1
CP002686 Genomic DNA Translation: AEE77309.1
CP002686 Genomic DNA Translation: AEE77310.1
AY035013 mRNA Translation: AAK59518.1
AY063053 mRNA Translation: AAL34227.1
AY924777 mRNA Translation: AAX23852.1
AY086901 mRNA Translation: AAM63946.1
RefSeqiNP_001118718.1, NM_001125246.1
NP_189374.1, NM_113653.4
UniGeneiAt.17610
At.22540
At.32384
At.71559

Genome annotation databases

EnsemblPlantsiAT3G27380.1; AT3G27380.1; AT3G27380
AT3G27380.2; AT3G27380.2; AT3G27380
GeneIDi822359
GrameneiAT3G27380.1; AT3G27380.1; AT3G27380
AT3G27380.2; AT3G27380.2; AT3G27380
KEGGiath:AT3G27380

Entry informationi

Entry nameiSDHB1_ARATH
AccessioniPrimary (citable) accession number: Q8LBZ7
Secondary accession number(s): Q9G3M0, Q9LTZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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