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Protein

60S ribosomal protein L5-1

Gene

ATL5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

  • 5S rRNA binding Source: TAIR
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

  • adaxial/abaxial pattern specification Source: TAIR
  • cell proliferation Source: TAIR
  • leaf morphogenesis Source: TAIR
  • mature ribosome assembly Source: CAFA
  • nucleocytoplasmic transport Source: TAIR
  • response to cytokinin Source: TAIR
  • ribosomal large subunit assembly Source: GO_Central
  • ribosome assembly Source: CAFA
  • root morphogenesis Source: TAIR
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-ATH-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-ATH-72689. Formation of a pool of free 40S subunits.
R-ATH-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-ATH-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5-1
Gene namesi
Name:ATL5
Synonyms:RPL5A
Ordered Locus Names:At3g25520
ORF Names:MWL2.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G25520.
TAIRilocus:2094508. AT3G25520.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002399191 – 30160S ribosomal protein L5-1Add BLAST301

Proteomic databases

PaxDbiQ8LBI1.
PRIDEiQ8LBI1.

PTM databases

iPTMnetiQ8LBI1.

Expressioni

Gene expression databases

ExpressionAtlasiQ8LBI1. baseline and differential.
GenevisibleiQ8LBI1. AT.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Protein-protein interaction databases

BioGridi7469. 10 interactors.
IntActiQ8LBI1. 7 interactors.
STRINGi3702.AT3G25520.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LBI1.
SMRiQ8LBI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0875. Eukaryota.
COG0256. LUCA.
HOGENOMiHOG000105947.
InParanoidiQ8LBI1.
KOiK02932.
OMAiVAEYMES.
OrthoDBiEOG09360IXD.
PhylomeDBiQ8LBI1.

Family and domain databases

HAMAPiMF_01337_A. Ribosomal_L18_A. 1 hit.
InterProiView protein in InterPro
IPR005485. Rbsml_L5_euk/L18_arc.
IPR025607. Rbsml_L5e/L18P_C.
PANTHERiPTHR23410. PTHR23410. 1 hit.
PfamiView protein in Pfam
PF14204. Ribosomal_L18_c. 1 hit.
PF17144. Ribosomal_L5e. 1 hit.
PRINTSiPR00058. RIBOSOMALL5.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8LBI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFVKSTKSN AYFKRYQVKF RRRRDGKTDY RARIRLINQD KNKYNTPKYR
60 70 80 90 100
FVVRFTNKDI VAQIVSASIA GDIVKASAYA HELPQYGLTV GLTNYAAAYC
110 120 130 140 150
TGLLLARRVL KMLEMDDEYE GNVEATGEDF SVEPTDSRRP FRALLDVGLI
160 170 180 190 200
RTTTGNRVFG ALKGALDGGL DIPHSDKRFA GFHKENKQLD AEIHRNYIYG
210 220 230 240 250
GHVSNYMKLL GEDEPEKLQT HFSAYIKKGV EAESIEELYK KVHAAIRADP
260 270 280 290 300
NPKKTVKPAP KQHKRYNLKK LTYEERKNKL IERVKALNGA GGDDDDEDDE

E
Length:301
Mass (Da):34,358
Last modified:June 13, 2006 - v2
Checksum:i9485CE63AB6ECD58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253K → R in AAM64753 (Ref. 5) Curated1
Sequence conflicti301E → Z in AAM64753 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186611 mRNA. Translation: AAO73340.1.
AB025639 Genomic DNA. No translation available.
CP002686 Genomic DNA. Translation: AEE77019.1.
CP002686 Genomic DNA. Translation: ANM65929.1.
AY054161 mRNA. Translation: AAL06822.1.
AY065103 mRNA. Translation: AAL38279.1.
AY081701 mRNA. Translation: AAM10263.1.
AY136319 mRNA. Translation: AAM96985.1.
BT000411 mRNA. Translation: AAN15730.1.
BT002427 mRNA. Translation: AAO00787.1.
BT008705 mRNA. Translation: AAP42718.1.
AY087197 mRNA. Translation: AAM64753.1.
RefSeqiNP_001327862.1. NM_001338753.1. [Q8LBI1-1]
NP_566767.1. NM_113448.5. [Q8LBI1-1]
UniGeneiAt.23809.
At.25396.

Genome annotation databases

EnsemblPlantsiAT3G25520.1; AT3G25520.1; AT3G25520. [Q8LBI1-1]
AT3G25520.3; AT3G25520.3; AT3G25520. [Q8LBI1-1]
GeneIDi822138.
GrameneiAT3G25520.1; AT3G25520.1; AT3G25520.
AT3G25520.3; AT3G25520.3; AT3G25520.
KEGGiath:AT3G25520.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL51_ARATH
AccessioniPrimary (citable) accession number: Q8LBI1
Secondary accession number(s): Q940R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: August 30, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families