Reviewed, UniProtKB/Swiss-Prot Q8LBC0 (CCT13_ARATH)

Names and origin

Protein names

Recommended name:
    Cyclin-T1-3
      Short name=CycT1;3

Gene names

Name:	CYCT1-3
Synonyms:	CYCT
Ordered Locus Names:	At1g27630
ORF Names:	T17H3.12, T22C5.7, T22C5.8

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with CDKC-1 and CDKC-2. Ref.6
Tissue specificity	Abundantly expressed in flowers. Expressed in roots, seedlings, rosettes and stems. Ref.6
Sequence similarities	Belongs to the cyclin family. Cyclin T subfamily.
Sequence caution	The sequence AAF24942.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Coding sequence diversity	Alternative splicing
Molecular function	Cyclin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: TAIR
Molecular function	protein binding Ref.6 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDKC-1	Q9LFT8	3	EBI-2025764,EBI-2025736
CDKC-2	Q8W4P1	1	EBI-2025764,EBI-2025894

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8LBC0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8LBC0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     78-317: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Cyclin-T1-3		PRO_0000287055
Natural variations
	Alternative sequence	78 – 317	240	Missing in isoform 2.		VSP_025286
Experimental info
	Sequence conflict	305	1	S → G in AAM67327. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 7DFB614BB525A5E7	FASTA	317	36,762
	10 20 30 40 50 60 MGEEHPRKRS RQHFEAEARN VSLFESPQCE TSKWYFSREE IERFSPSRKD GIDLVKESFL 70 80 90 100 110 120 RSSYCTFLQR LGMKLHVSQV TISCAMVMCH RFYMRQSHAK NDWQTIATSS LFLACKAEDE 130 140 150 160 170 180 PCQLSSVVVA SYEIIYEWDP SASIRIHQTE CYHEFKEIIL SGESLLLSTS AFHLDIELPY 190 200 210 220 230 240 KPLAAALNRL NAWPDLATAA WNFVHDWIRT TLCLQYKPHV IATATVHLAA TFQNAKVGSR 250 260 270 280 290 300 RDWWLEFGVT TKLLKEVIQE MCTLIEVDRR RNMPPPPPPP RRELSWAIPA AVKPVHMARA 310 YPFHSYPLQS YRQAGIW
	Isoform 2. Checksum: 5F55DEAF156E65C0	FASTA	77	9,240
	10 20 30 40 50 60 MGEEHPRKRS RQHFEAEARN VSLFESPQCE TSKWYFSREE IERFSPSRKD GIDLVKESFL 70 RSSYCTFLQR LGMKLHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: cv. Columbia.
[4]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: cv. Columbia.
[5]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division." Barroco R.M., de Veylder L., Magyar Z., Engler G., Inze D., Mironov V. Cell. Mol. Life Sci. 60:401-412(2003) [PubMed: 12678503] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH CDKC-1 AND CDKC-2.
[7]	"Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins." Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W., Ma H. Plant Physiol. 135:1084-1099(2004) [PubMed: 15208425] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC005916 Genomic DNA. Translation: AAD46000.1. AC012375 Genomic DNA. Translation: AAF24941.1. AC012375 Genomic DNA. Translation: AAF24942.1. Sequence problems. AK117692 mRNA. Translation: BAC42344.1. AF344323 mRNA. Translation: AAK06874.1. AY062805 mRNA. Translation: AAL32883.1. AY081601 mRNA. Translation: AAM10163.1. AK229729 mRNA. Translation: BAF01567.1. AY087303 mRNA. Translation: AAM67327.1.
IPI	IPI00533908. IPI00846873.
PIR	D86401.
RefSeq	NP_174084.1.
UniGene	At.11523
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8LBC0. 2 interactions.
STRING	Q8LBC0.
Genome annotation databases
GeneID	839655.
GenomeReviews	Gene locus AT1G27630 in contig CT485782_GR.
KEGG	ath:AT1G27630.
NMPDR	fig|3702.1.peg.3093.
Organism-specific databases
GeneFarm	4113. 417.
TAIR	At1g27630.
Phylogenomic databases
OMA	CYTVLCY
Gene expression databases
Genevestigator	Q8LBC0.
Family and domain databases
InterPro	IPR006670. Cyclin. IPR011028. Cyclin-like. IPR006671. Cyclin_N. IPR015429. Tscrpt_reg_cyclin. [Graphical view]
PANTHER	PTHR10026. Trans_reg_cyclin. 1 hit.
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCT13_ARATH

Accession

Primary (citable) accession number: Q8LBC0
Secondary accession number(s): Q9SFZ4, Q9SFZ5, Q9SXC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	November 24, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)